Impact of angiotensin II receptor blockers on the progression and regression of coronary atherosclerosis - An intravascular ultrasound study

Katsuhisa Waseda, Yukio Ozaki, Hiroaki Takashima, Junya Ako, Tatsuya Yasukawa, Tevfik F. Ismail, Hitoshi Hishida, Takayuki Ito

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Although angiotensin II receptor blockers (ARB) have been found to reduce the coronary atherosclerotic plaque burden in animal models, it is unknown whether ARB have a similar effect on human coronary arteries. Methods and Results: Serial intravascular ultrasound (IVUS) studies of the left main (LM) coronary artery were performed in 64 patients at baseline and after 7-month follow-up. All patients were divided into 2 groups (ARB group: 23 patients; non-ARB group: 41 patients). Three-dimensional volumetric analysis was done throughout the LM coronary artery, and the volume index (VI; volume/length) was calculated for the vessel (VVI), lumen (LVI), and plaque (PVI). No significant difference was found between the 2 groups in baseline clinical characteristics, including age, gender, blood pressure levels, serum cholesterol levels, the presence of diabetes and smoking status. At baseline VVI, LVI and PVI were similar between the groups. In the non-ARB group, VVI, LVI, and PVI did not change between baseline and follow-up. In the ARB group, PVI significantly decreased during follow-up (9.9±3.1 mm 2 vs 9.1±2.7 mm 2, p<0.01), whereas VVI and LVI were unaffected. Conclusions: This preliminary IVUS study suggests that ARB could cause regression of coronary atherosclerosis in humans.

Original languageEnglish
Pages (from-to)1111-1115
Number of pages5
JournalCirculation Journal
Volume70
Issue number9
DOIs
Publication statusPublished - 20-09-2006

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Angiotensin Receptor Antagonists
Coronary Artery Disease
Coronary Vessels
Atherosclerotic Plaques
Animal Models
Smoking
Cholesterol
Blood Pressure
Serum

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Waseda, Katsuhisa ; Ozaki, Yukio ; Takashima, Hiroaki ; Ako, Junya ; Yasukawa, Tatsuya ; Ismail, Tevfik F. ; Hishida, Hitoshi ; Ito, Takayuki. / Impact of angiotensin II receptor blockers on the progression and regression of coronary atherosclerosis - An intravascular ultrasound study. In: Circulation Journal. 2006 ; Vol. 70, No. 9. pp. 1111-1115.
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Impact of angiotensin II receptor blockers on the progression and regression of coronary atherosclerosis - An intravascular ultrasound study. / Waseda, Katsuhisa; Ozaki, Yukio; Takashima, Hiroaki; Ako, Junya; Yasukawa, Tatsuya; Ismail, Tevfik F.; Hishida, Hitoshi; Ito, Takayuki.

In: Circulation Journal, Vol. 70, No. 9, 20.09.2006, p. 1111-1115.

Research output: Contribution to journalArticle

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T1 - Impact of angiotensin II receptor blockers on the progression and regression of coronary atherosclerosis - An intravascular ultrasound study

AU - Waseda, Katsuhisa

AU - Ozaki, Yukio

AU - Takashima, Hiroaki

AU - Ako, Junya

AU - Yasukawa, Tatsuya

AU - Ismail, Tevfik F.

AU - Hishida, Hitoshi

AU - Ito, Takayuki

PY - 2006/9/20

Y1 - 2006/9/20

N2 - Background: Although angiotensin II receptor blockers (ARB) have been found to reduce the coronary atherosclerotic plaque burden in animal models, it is unknown whether ARB have a similar effect on human coronary arteries. Methods and Results: Serial intravascular ultrasound (IVUS) studies of the left main (LM) coronary artery were performed in 64 patients at baseline and after 7-month follow-up. All patients were divided into 2 groups (ARB group: 23 patients; non-ARB group: 41 patients). Three-dimensional volumetric analysis was done throughout the LM coronary artery, and the volume index (VI; volume/length) was calculated for the vessel (VVI), lumen (LVI), and plaque (PVI). No significant difference was found between the 2 groups in baseline clinical characteristics, including age, gender, blood pressure levels, serum cholesterol levels, the presence of diabetes and smoking status. At baseline VVI, LVI and PVI were similar between the groups. In the non-ARB group, VVI, LVI, and PVI did not change between baseline and follow-up. In the ARB group, PVI significantly decreased during follow-up (9.9±3.1 mm 2 vs 9.1±2.7 mm 2, p<0.01), whereas VVI and LVI were unaffected. Conclusions: This preliminary IVUS study suggests that ARB could cause regression of coronary atherosclerosis in humans.

AB - Background: Although angiotensin II receptor blockers (ARB) have been found to reduce the coronary atherosclerotic plaque burden in animal models, it is unknown whether ARB have a similar effect on human coronary arteries. Methods and Results: Serial intravascular ultrasound (IVUS) studies of the left main (LM) coronary artery were performed in 64 patients at baseline and after 7-month follow-up. All patients were divided into 2 groups (ARB group: 23 patients; non-ARB group: 41 patients). Three-dimensional volumetric analysis was done throughout the LM coronary artery, and the volume index (VI; volume/length) was calculated for the vessel (VVI), lumen (LVI), and plaque (PVI). No significant difference was found between the 2 groups in baseline clinical characteristics, including age, gender, blood pressure levels, serum cholesterol levels, the presence of diabetes and smoking status. At baseline VVI, LVI and PVI were similar between the groups. In the non-ARB group, VVI, LVI, and PVI did not change between baseline and follow-up. In the ARB group, PVI significantly decreased during follow-up (9.9±3.1 mm 2 vs 9.1±2.7 mm 2, p<0.01), whereas VVI and LVI were unaffected. Conclusions: This preliminary IVUS study suggests that ARB could cause regression of coronary atherosclerosis in humans.

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