TY - JOUR
T1 - Impact of cigarette smoking on coronary plaque composition
AU - Kumagai, Soichiro
AU - Amano, Tetsuya
AU - Takashima, Hiroaki
AU - Waseda, Katsuhisa
AU - Kurita, Akiyoshi
AU - Ando, Hirohiko
AU - Maeda, Kazuyuki
AU - Ito, Yoshitaka
AU - Ishii, Hideki
AU - Hayashi, Mutsuharu
AU - Yoshikawa, Daiji
AU - Suzuki, Susumu
AU - Tanaka, Akihito
AU - Matsubara, Tatsuaki
AU - Muroharab, Toyoaki
N1 - Publisher Copyright:
© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.
PY - 2015/1/14
Y1 - 2015/1/14
N2 - Objectives Cigarette smoking is associated with atherosclerosis and is an important risk factor for cardiovascular disease. We evaluated the impact of cigarette smoking on coronary plaque composition using integrated backscatter intravascular ultrasound (IB-IVUS).Methods A total of 143 consecutive patients undergoing percutaneous coronary intervention were enrolled. A history of illness, as well as smoking habits, was obtained by interview. Participants were asked to report whether they were current smokers, had quit smoking, or had never smoked. According to interview results, patients were divided into the following three groups: current, former, and never smokers. Conventional and IB-IVUS tissue characterization analyses were carried out. Three dimensional analyses were carried out to determine plaque volume and the volume of each plaque component (lipid, fibrous, and calcified).Results IB-IVUS analysis indicated that the patients in the current smoker group had significantly increased percent lipid volume and significantly decreased percent fibrous volume (P=0.01 and 0.03). Logistic regression analysis showed that the current smoking state (odds ratio 3.51, 95% confidence interval 1.0212.10, P=0.04) was independently associated with the presence of lipid-rich plaques, which was defined as the upper 75th percentile of the study population.Conclusion Smoking is independently associated with lipid-rich plaques, contributing to the increasing risk for plaque vulnerability.
AB - Objectives Cigarette smoking is associated with atherosclerosis and is an important risk factor for cardiovascular disease. We evaluated the impact of cigarette smoking on coronary plaque composition using integrated backscatter intravascular ultrasound (IB-IVUS).Methods A total of 143 consecutive patients undergoing percutaneous coronary intervention were enrolled. A history of illness, as well as smoking habits, was obtained by interview. Participants were asked to report whether they were current smokers, had quit smoking, or had never smoked. According to interview results, patients were divided into the following three groups: current, former, and never smokers. Conventional and IB-IVUS tissue characterization analyses were carried out. Three dimensional analyses were carried out to determine plaque volume and the volume of each plaque component (lipid, fibrous, and calcified).Results IB-IVUS analysis indicated that the patients in the current smoker group had significantly increased percent lipid volume and significantly decreased percent fibrous volume (P=0.01 and 0.03). Logistic regression analysis showed that the current smoking state (odds ratio 3.51, 95% confidence interval 1.0212.10, P=0.04) was independently associated with the presence of lipid-rich plaques, which was defined as the upper 75th percentile of the study population.Conclusion Smoking is independently associated with lipid-rich plaques, contributing to the increasing risk for plaque vulnerability.
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U2 - 10.1097/MCA.0000000000000168
DO - 10.1097/MCA.0000000000000168
M3 - Article
C2 - 25171387
AN - SCOPUS:84918541238
SN - 0954-6928
VL - 26
SP - 60
EP - 65
JO - Coronary Artery Disease
JF - Coronary Artery Disease
IS - 1
ER -
