Impact of cigarette smoking on coronary plaque composition

Soichiro Kumagai, Tetsuya Amano, Hiroaki Takashima, Katsuhisa Waseda, Akiyoshi Kurita, Hirohiko Ando, Kazuyuki Maeda, Yoshitaka Ito, Hideki Ishii, Mutsuharu Hayashi, Daiji Yoshikawa, Susumu Suzuki, Akihito Tanaka, Tatsuaki Matsubara, Toyoaki Muroharab

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Objectives Cigarette smoking is associated with atherosclerosis and is an important risk factor for cardiovascular disease. We evaluated the impact of cigarette smoking on coronary plaque composition using integrated backscatter intravascular ultrasound (IB-IVUS).

Methods A total of 143 consecutive patients undergoing percutaneous coronary intervention were enrolled. A history of illness, as well as smoking habits, was obtained by interview. Participants were asked to report whether they were current smokers, had quit smoking, or had never smoked. According to interview results, patients were divided into the following three groups: current, former, and never smokers. Conventional and IB-IVUS tissue characterization analyses were carried out. Three dimensional analyses were carried out to determine plaque volume and the volume of each plaque component (lipid, fibrous, and calcified).

Results IB-IVUS analysis indicated that the patients in the current smoker group had significantly increased percent lipid volume and significantly decreased percent fibrous volume (P=0.01 and 0.03). Logistic regression analysis showed that the current smoking state (odds ratio 3.51, 95% confidence interval 1.0212.10, P=0.04) was independently associated with the presence of lipid-rich plaques, which was defined as the upper 75th percentile of the study population.

Conclusion Smoking is independently associated with lipid-rich plaques, contributing to the increasing risk for plaque vulnerability.

Original languageEnglish
Pages (from-to)60-65
Number of pages6
JournalCoronary Artery Disease
Issue number1
Publication statusPublished - 14-01-2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Impact of cigarette smoking on coronary plaque composition'. Together they form a unique fingerprint.

Cite this