Impact of circulating cathepsin K on the coronary calcification and the clinical outcome in chronic kidney disease patients

Yusuke Izumi, Mutsuharu Hayashi, Ryota Morimoto, Xian Wu Cheng, Hongxian Wu, Hideki Ishii, Yoshinari Yasuda, Daiji Yoshikawa, Hideo Izawa, Seiichi Matsuo, Yutaka Oiso, Toyoaki Murohara

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Chronic kidney disease (CKD) is a cause of coronary artery calcification (CAC) and an independent predictor of major adverse cardiac and cerebrovascular events (MACCE). Cathepsin K (CatK) is a lysosomal cysteine protease which affects vascular calcification and glucose metabolism disorder. We investigated the relationships among CatK, CAC, diabetes mellitus (DM) and MACCE in CKD patients. 113 consecutive CKD patients were enrolled. Their CAC was evaluated by computed tomography. Their plasma CatK level was measured by ELISA. They were divided into two groups by CatK levels and followed up for up to 3 years. The impact of CatK was analyzed in all participants, diabetic patients and non-diabetic patients. Kaplan–Meier analysis demonstrated a significant higher incidence of MACCE in the high CatK group (P = 0.028). The CatK level was significantly higher in patients with MACCE compared to that in patients without MACCE (P = 0.034). Cox’s model revealed the higher plasma CatK and BNP level as independent predictors of MACCE (P = 0.043 and P < 0.01, respectively). Only in non-diabetic patients, there was a significant correlation between CatK and CAC score, and high CatK group had a significant higher level of LDL-C and LDL-C/HDL-C ratio (P < 0.05 and P < 0.001, respectively) than low CatK group. And these lipid disorders were independent predictors of CatK elevation. In CKD patients, our results indicated an impact of higher CatK level on their MACCE. The significant association among the CatK level, CAC and MACCE was found in non-diabetic CKD patients.

Original languageEnglish
Pages (from-to)6-14
Number of pages9
JournalHeart and Vessels
Volume31
Issue number1
DOIs
Publication statusPublished - 01-01-2016

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Cathepsin K
Chronic Renal Insufficiency
Coronary Vessels
Glucose Metabolism Disorders
Vascular Calcification
Cysteine Proteases

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Izumi, Yusuke ; Hayashi, Mutsuharu ; Morimoto, Ryota ; Cheng, Xian Wu ; Wu, Hongxian ; Ishii, Hideki ; Yasuda, Yoshinari ; Yoshikawa, Daiji ; Izawa, Hideo ; Matsuo, Seiichi ; Oiso, Yutaka ; Murohara, Toyoaki. / Impact of circulating cathepsin K on the coronary calcification and the clinical outcome in chronic kidney disease patients. In: Heart and Vessels. 2016 ; Vol. 31, No. 1. pp. 6-14.
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abstract = "Chronic kidney disease (CKD) is a cause of coronary artery calcification (CAC) and an independent predictor of major adverse cardiac and cerebrovascular events (MACCE). Cathepsin K (CatK) is a lysosomal cysteine protease which affects vascular calcification and glucose metabolism disorder. We investigated the relationships among CatK, CAC, diabetes mellitus (DM) and MACCE in CKD patients. 113 consecutive CKD patients were enrolled. Their CAC was evaluated by computed tomography. Their plasma CatK level was measured by ELISA. They were divided into two groups by CatK levels and followed up for up to 3 years. The impact of CatK was analyzed in all participants, diabetic patients and non-diabetic patients. Kaplan–Meier analysis demonstrated a significant higher incidence of MACCE in the high CatK group (P = 0.028). The CatK level was significantly higher in patients with MACCE compared to that in patients without MACCE (P = 0.034). Cox’s model revealed the higher plasma CatK and BNP level as independent predictors of MACCE (P = 0.043 and P < 0.01, respectively). Only in non-diabetic patients, there was a significant correlation between CatK and CAC score, and high CatK group had a significant higher level of LDL-C and LDL-C/HDL-C ratio (P < 0.05 and P < 0.001, respectively) than low CatK group. And these lipid disorders were independent predictors of CatK elevation. In CKD patients, our results indicated an impact of higher CatK level on their MACCE. The significant association among the CatK level, CAC and MACCE was found in non-diabetic CKD patients.",
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Izumi, Y, Hayashi, M, Morimoto, R, Cheng, XW, Wu, H, Ishii, H, Yasuda, Y, Yoshikawa, D, Izawa, H, Matsuo, S, Oiso, Y & Murohara, T 2016, 'Impact of circulating cathepsin K on the coronary calcification and the clinical outcome in chronic kidney disease patients', Heart and Vessels, vol. 31, no. 1, pp. 6-14. https://doi.org/10.1007/s00380-014-0570-z

Impact of circulating cathepsin K on the coronary calcification and the clinical outcome in chronic kidney disease patients. / Izumi, Yusuke; Hayashi, Mutsuharu; Morimoto, Ryota; Cheng, Xian Wu; Wu, Hongxian; Ishii, Hideki; Yasuda, Yoshinari; Yoshikawa, Daiji; Izawa, Hideo; Matsuo, Seiichi; Oiso, Yutaka; Murohara, Toyoaki.

In: Heart and Vessels, Vol. 31, No. 1, 01.01.2016, p. 6-14.

Research output: Contribution to journalArticle

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T1 - Impact of circulating cathepsin K on the coronary calcification and the clinical outcome in chronic kidney disease patients

AU - Izumi, Yusuke

AU - Hayashi, Mutsuharu

AU - Morimoto, Ryota

AU - Cheng, Xian Wu

AU - Wu, Hongxian

AU - Ishii, Hideki

AU - Yasuda, Yoshinari

AU - Yoshikawa, Daiji

AU - Izawa, Hideo

AU - Matsuo, Seiichi

AU - Oiso, Yutaka

AU - Murohara, Toyoaki

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Chronic kidney disease (CKD) is a cause of coronary artery calcification (CAC) and an independent predictor of major adverse cardiac and cerebrovascular events (MACCE). Cathepsin K (CatK) is a lysosomal cysteine protease which affects vascular calcification and glucose metabolism disorder. We investigated the relationships among CatK, CAC, diabetes mellitus (DM) and MACCE in CKD patients. 113 consecutive CKD patients were enrolled. Their CAC was evaluated by computed tomography. Their plasma CatK level was measured by ELISA. They were divided into two groups by CatK levels and followed up for up to 3 years. The impact of CatK was analyzed in all participants, diabetic patients and non-diabetic patients. Kaplan–Meier analysis demonstrated a significant higher incidence of MACCE in the high CatK group (P = 0.028). The CatK level was significantly higher in patients with MACCE compared to that in patients without MACCE (P = 0.034). Cox’s model revealed the higher plasma CatK and BNP level as independent predictors of MACCE (P = 0.043 and P < 0.01, respectively). Only in non-diabetic patients, there was a significant correlation between CatK and CAC score, and high CatK group had a significant higher level of LDL-C and LDL-C/HDL-C ratio (P < 0.05 and P < 0.001, respectively) than low CatK group. And these lipid disorders were independent predictors of CatK elevation. In CKD patients, our results indicated an impact of higher CatK level on their MACCE. The significant association among the CatK level, CAC and MACCE was found in non-diabetic CKD patients.

AB - Chronic kidney disease (CKD) is a cause of coronary artery calcification (CAC) and an independent predictor of major adverse cardiac and cerebrovascular events (MACCE). Cathepsin K (CatK) is a lysosomal cysteine protease which affects vascular calcification and glucose metabolism disorder. We investigated the relationships among CatK, CAC, diabetes mellitus (DM) and MACCE in CKD patients. 113 consecutive CKD patients were enrolled. Their CAC was evaluated by computed tomography. Their plasma CatK level was measured by ELISA. They were divided into two groups by CatK levels and followed up for up to 3 years. The impact of CatK was analyzed in all participants, diabetic patients and non-diabetic patients. Kaplan–Meier analysis demonstrated a significant higher incidence of MACCE in the high CatK group (P = 0.028). The CatK level was significantly higher in patients with MACCE compared to that in patients without MACCE (P = 0.034). Cox’s model revealed the higher plasma CatK and BNP level as independent predictors of MACCE (P = 0.043 and P < 0.01, respectively). Only in non-diabetic patients, there was a significant correlation between CatK and CAC score, and high CatK group had a significant higher level of LDL-C and LDL-C/HDL-C ratio (P < 0.05 and P < 0.001, respectively) than low CatK group. And these lipid disorders were independent predictors of CatK elevation. In CKD patients, our results indicated an impact of higher CatK level on their MACCE. The significant association among the CatK level, CAC and MACCE was found in non-diabetic CKD patients.

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