TY - JOUR
T1 - Impact of Continuous Nutritional Counseling on Liver Function and Body Composition in Patients with MASLD/MASH
AU - Asai, Shiho
AU - Kawabe, Naoto
AU - Ito, Akemi
AU - Kuzuya, Teiji
AU - Ohno, Eizaburo
AU - Nakano, Takuji
AU - Nakaoka, Kazunori
AU - Tanaka, Hiroyuki
AU - Ochi, Yuka
AU - Miyaji, Sayuri
AU - Morisaki, Sayaka
AU - Hirooka, Yoshiki
N1 - Publisher Copyright:
© 2025 The Japan Society of Hepatology.
PY - 2025
Y1 - 2025
N2 - In Japan, the prevalence of obesity, a major risk factor for metabolic dysfunction-associated steatotic liver disease (MASLD)/metabolic dysfunction-associated steatohepatitis (MASH), has been increasing due to west-ernized diets and physical inactivity. We evaluated the efficacy of continuous nutritional counseling in 58 patients with a body mass index of ≥25 kg/m2 who were diagnosed with MASLD/MASH. Nutritional counseling, body composition measurement, blood biochemistry, and liver function tests were conducted at baseline and 12 months. Weight loss with continuous nutritional counseling was associated with significant decreases in lean body mass (P = 0.006), body mass index (P = 0.000), body fat percentage (P = 0.000), alkaline and aspartate aminotransferase levels (P = 0.001 and P = 0.000, respectively), liver stiffness (P = 0.006), and liver steatosis, de-termined with controlled attenuation parameter (P = 0.006). These results suggest that continuous nutritional counseling is effective in reducing body fat percentage and improving liver function in patients with MASLD/ MASH.
AB - In Japan, the prevalence of obesity, a major risk factor for metabolic dysfunction-associated steatotic liver disease (MASLD)/metabolic dysfunction-associated steatohepatitis (MASH), has been increasing due to west-ernized diets and physical inactivity. We evaluated the efficacy of continuous nutritional counseling in 58 patients with a body mass index of ≥25 kg/m2 who were diagnosed with MASLD/MASH. Nutritional counseling, body composition measurement, blood biochemistry, and liver function tests were conducted at baseline and 12 months. Weight loss with continuous nutritional counseling was associated with significant decreases in lean body mass (P = 0.006), body mass index (P = 0.000), body fat percentage (P = 0.000), alkaline and aspartate aminotransferase levels (P = 0.001 and P = 0.000, respectively), liver stiffness (P = 0.006), and liver steatosis, de-termined with controlled attenuation parameter (P = 0.006). These results suggest that continuous nutritional counseling is effective in reducing body fat percentage and improving liver function in patients with MASLD/ MASH.
KW - metabolic dysfunction-associated steatohepatitis
KW - metabolic dysfunction-associated steatotic liver disease
KW - nutritional counseling
KW - weight loss diet
UR - https://www.scopus.com/pages/publications/105008240165
UR - https://www.scopus.com/pages/publications/105008240165#tab=citedBy
U2 - 10.2957/kanzo.66.222
DO - 10.2957/kanzo.66.222
M3 - Article
AN - SCOPUS:105008240165
SN - 0451-4203
VL - 66
SP - 222
EP - 232
JO - Kanzo/Acta Hepatologica Japonica
JF - Kanzo/Acta Hepatologica Japonica
IS - 6
ER -
