Impact of Continuous Nutritional Counseling on Liver Function and Body Composition in Patients with MASLD/MASH

In Japan, the prevalence of obesity, a major risk factor for metabolic dysfunction-associated steatotic liver disease (MASLD)/metabolic dysfunction-associated steatohepatitis (MASH), has been increasing due to west-ernized diets and physical inactivity. We evaluated the efficacy of continuous nutritional counseling in 58 patients with a body mass index of ≥25 kg/m² who were diagnosed with MASLD/MASH. Nutritional counseling, body composition measurement, blood biochemistry, and liver function tests were conducted at baseline and 12 months. Weight loss with continuous nutritional counseling was associated with significant decreases in lean body mass (P = 0.006), body mass index (P = 0.000), body fat percentage (P = 0.000), alkaline and aspartate aminotransferase levels (P = 0.001 and P = 0.000, respectively), liver stiffness (P = 0.006), and liver steatosis, de-termined with controlled attenuation parameter (P = 0.006). These results suggest that continuous nutritional counseling is effective in reducing body fat percentage and improving liver function in patients with MASLD/ MASH.