Impact of cutting balloon angioplasty (CBA) prior to bare metal stenting on restenosis a prospective randomized multicenter trial comparing CBA with balloon angioplasty (BA) before stenting (REDUCE III)

Yukio Ozaki, Tetsu Yamaguchi, Takahiko Suzuki, Masato Nakamura, Michihiko Kitayama, Hideo Nishikawa, Teruo Inoue, Kazuhiro Kara, Fumihiko Usuba, Masami Sakurada, Kojiro Awano, Hitoshi Matsuo, Sugao Ishiwata, Tatsuya Yasukawa, Tevfik F. Ismail, Hitoshi Hishida, Osamu Kato

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: While stent restenosis and late thrombosis still occur even with drug-eluting-stents (DES), there remains a need to explore other strategies for preventing restenosis. Methods and Results: Five hundred and twenty-one patients were randomized: 260 to cutting-balloon angioplasty (CBA) before bare-metal stent (CBA-BMS) and 261 to balloon-angioplasty (BA) before BMS (BA-BMS). Intravascular ultrasound (IVUS)-guided procedures were performed in 279 (54%) patients and angiographic guidance was used in the remainder. Minimal lumen diameter was significantly greater in CBA-BMS than BA-BMS (2.65±0.40 mm vs 2.52±0.4 mm, p<0.01) and % diameter stenosis (%DS)-post was less in CBA-BMS than BA-BMS (14.0±5.9% vs 16.3±6.8%, p<0.01). %DS-follow-up was subsequently less in CBA-BMS than BABMS (32.4±15.1% vs 35.4±15.3%, p<0.05) associated with lower rates of restenosis in CBA-BMS than BA-BMS (11.8% vs 19.6%, p<0.05) and less target lesion revascularization (TLR) in CBA-BMS than BA-BMS (9.6% vs 15.3%, p<0.05). Patients were divided into 4 groups based on the device used before stenting and IVUS use (IVUS-CBA-BMS: 137 patients; Angio-CBA-BMS; 123; IVUS-BA-BMS: 142; and Angio-BA-BMS: 119). At follow-up IVUS-CBA-BMS had a significantly lower restenosis rate (6.6%) than Angio-CBA-BMS (17.9%), IVUS-BA-BMS (19.8%) and Angio-BA-BMS (18.2%, p<0.05). Conclusions: Restenosis and TLR were significantly lower in CBA-BMS than BA-BMS. This favorable outcome was achieved because of the lower restenosis rate conferred by the IVUS-guided-CBA-BMS strategy (6.6%). The restenosis rates obtained with this strategy were comparable to those achieved with DES.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalCirculation Journal
Volume71
Issue number1
DOIs
Publication statusPublished - 10-01-2007

Fingerprint

Balloon Angioplasty
Multicenter Studies
Metals
Drug-Eluting Stents
Stents

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Ozaki, Yukio ; Yamaguchi, Tetsu ; Suzuki, Takahiko ; Nakamura, Masato ; Kitayama, Michihiko ; Nishikawa, Hideo ; Inoue, Teruo ; Kara, Kazuhiro ; Usuba, Fumihiko ; Sakurada, Masami ; Awano, Kojiro ; Matsuo, Hitoshi ; Ishiwata, Sugao ; Yasukawa, Tatsuya ; Ismail, Tevfik F. ; Hishida, Hitoshi ; Kato, Osamu. / Impact of cutting balloon angioplasty (CBA) prior to bare metal stenting on restenosis a prospective randomized multicenter trial comparing CBA with balloon angioplasty (BA) before stenting (REDUCE III). In: Circulation Journal. 2007 ; Vol. 71, No. 1. pp. 1-8.
@article{85525d204450445ab8f809a96a0f9b90,
title = "Impact of cutting balloon angioplasty (CBA) prior to bare metal stenting on restenosis a prospective randomized multicenter trial comparing CBA with balloon angioplasty (BA) before stenting (REDUCE III)",
abstract = "Background: While stent restenosis and late thrombosis still occur even with drug-eluting-stents (DES), there remains a need to explore other strategies for preventing restenosis. Methods and Results: Five hundred and twenty-one patients were randomized: 260 to cutting-balloon angioplasty (CBA) before bare-metal stent (CBA-BMS) and 261 to balloon-angioplasty (BA) before BMS (BA-BMS). Intravascular ultrasound (IVUS)-guided procedures were performed in 279 (54{\%}) patients and angiographic guidance was used in the remainder. Minimal lumen diameter was significantly greater in CBA-BMS than BA-BMS (2.65±0.40 mm vs 2.52±0.4 mm, p<0.01) and {\%} diameter stenosis ({\%}DS)-post was less in CBA-BMS than BA-BMS (14.0±5.9{\%} vs 16.3±6.8{\%}, p<0.01). {\%}DS-follow-up was subsequently less in CBA-BMS than BABMS (32.4±15.1{\%} vs 35.4±15.3{\%}, p<0.05) associated with lower rates of restenosis in CBA-BMS than BA-BMS (11.8{\%} vs 19.6{\%}, p<0.05) and less target lesion revascularization (TLR) in CBA-BMS than BA-BMS (9.6{\%} vs 15.3{\%}, p<0.05). Patients were divided into 4 groups based on the device used before stenting and IVUS use (IVUS-CBA-BMS: 137 patients; Angio-CBA-BMS; 123; IVUS-BA-BMS: 142; and Angio-BA-BMS: 119). At follow-up IVUS-CBA-BMS had a significantly lower restenosis rate (6.6{\%}) than Angio-CBA-BMS (17.9{\%}), IVUS-BA-BMS (19.8{\%}) and Angio-BA-BMS (18.2{\%}, p<0.05). Conclusions: Restenosis and TLR were significantly lower in CBA-BMS than BA-BMS. This favorable outcome was achieved because of the lower restenosis rate conferred by the IVUS-guided-CBA-BMS strategy (6.6{\%}). The restenosis rates obtained with this strategy were comparable to those achieved with DES.",
author = "Yukio Ozaki and Tetsu Yamaguchi and Takahiko Suzuki and Masato Nakamura and Michihiko Kitayama and Hideo Nishikawa and Teruo Inoue and Kazuhiro Kara and Fumihiko Usuba and Masami Sakurada and Kojiro Awano and Hitoshi Matsuo and Sugao Ishiwata and Tatsuya Yasukawa and Ismail, {Tevfik F.} and Hitoshi Hishida and Osamu Kato",
year = "2007",
month = "1",
day = "10",
doi = "10.1253/circj.71.1",
language = "English",
volume = "71",
pages = "1--8",
journal = "Circulation Journal",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "1",

}

Ozaki, Y, Yamaguchi, T, Suzuki, T, Nakamura, M, Kitayama, M, Nishikawa, H, Inoue, T, Kara, K, Usuba, F, Sakurada, M, Awano, K, Matsuo, H, Ishiwata, S, Yasukawa, T, Ismail, TF, Hishida, H & Kato, O 2007, 'Impact of cutting balloon angioplasty (CBA) prior to bare metal stenting on restenosis a prospective randomized multicenter trial comparing CBA with balloon angioplasty (BA) before stenting (REDUCE III)', Circulation Journal, vol. 71, no. 1, pp. 1-8. https://doi.org/10.1253/circj.71.1

Impact of cutting balloon angioplasty (CBA) prior to bare metal stenting on restenosis a prospective randomized multicenter trial comparing CBA with balloon angioplasty (BA) before stenting (REDUCE III). / Ozaki, Yukio; Yamaguchi, Tetsu; Suzuki, Takahiko; Nakamura, Masato; Kitayama, Michihiko; Nishikawa, Hideo; Inoue, Teruo; Kara, Kazuhiro; Usuba, Fumihiko; Sakurada, Masami; Awano, Kojiro; Matsuo, Hitoshi; Ishiwata, Sugao; Yasukawa, Tatsuya; Ismail, Tevfik F.; Hishida, Hitoshi; Kato, Osamu.

In: Circulation Journal, Vol. 71, No. 1, 10.01.2007, p. 1-8.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of cutting balloon angioplasty (CBA) prior to bare metal stenting on restenosis a prospective randomized multicenter trial comparing CBA with balloon angioplasty (BA) before stenting (REDUCE III)

AU - Ozaki, Yukio

AU - Yamaguchi, Tetsu

AU - Suzuki, Takahiko

AU - Nakamura, Masato

AU - Kitayama, Michihiko

AU - Nishikawa, Hideo

AU - Inoue, Teruo

AU - Kara, Kazuhiro

AU - Usuba, Fumihiko

AU - Sakurada, Masami

AU - Awano, Kojiro

AU - Matsuo, Hitoshi

AU - Ishiwata, Sugao

AU - Yasukawa, Tatsuya

AU - Ismail, Tevfik F.

AU - Hishida, Hitoshi

AU - Kato, Osamu

PY - 2007/1/10

Y1 - 2007/1/10

N2 - Background: While stent restenosis and late thrombosis still occur even with drug-eluting-stents (DES), there remains a need to explore other strategies for preventing restenosis. Methods and Results: Five hundred and twenty-one patients were randomized: 260 to cutting-balloon angioplasty (CBA) before bare-metal stent (CBA-BMS) and 261 to balloon-angioplasty (BA) before BMS (BA-BMS). Intravascular ultrasound (IVUS)-guided procedures were performed in 279 (54%) patients and angiographic guidance was used in the remainder. Minimal lumen diameter was significantly greater in CBA-BMS than BA-BMS (2.65±0.40 mm vs 2.52±0.4 mm, p<0.01) and % diameter stenosis (%DS)-post was less in CBA-BMS than BA-BMS (14.0±5.9% vs 16.3±6.8%, p<0.01). %DS-follow-up was subsequently less in CBA-BMS than BABMS (32.4±15.1% vs 35.4±15.3%, p<0.05) associated with lower rates of restenosis in CBA-BMS than BA-BMS (11.8% vs 19.6%, p<0.05) and less target lesion revascularization (TLR) in CBA-BMS than BA-BMS (9.6% vs 15.3%, p<0.05). Patients were divided into 4 groups based on the device used before stenting and IVUS use (IVUS-CBA-BMS: 137 patients; Angio-CBA-BMS; 123; IVUS-BA-BMS: 142; and Angio-BA-BMS: 119). At follow-up IVUS-CBA-BMS had a significantly lower restenosis rate (6.6%) than Angio-CBA-BMS (17.9%), IVUS-BA-BMS (19.8%) and Angio-BA-BMS (18.2%, p<0.05). Conclusions: Restenosis and TLR were significantly lower in CBA-BMS than BA-BMS. This favorable outcome was achieved because of the lower restenosis rate conferred by the IVUS-guided-CBA-BMS strategy (6.6%). The restenosis rates obtained with this strategy were comparable to those achieved with DES.

AB - Background: While stent restenosis and late thrombosis still occur even with drug-eluting-stents (DES), there remains a need to explore other strategies for preventing restenosis. Methods and Results: Five hundred and twenty-one patients were randomized: 260 to cutting-balloon angioplasty (CBA) before bare-metal stent (CBA-BMS) and 261 to balloon-angioplasty (BA) before BMS (BA-BMS). Intravascular ultrasound (IVUS)-guided procedures were performed in 279 (54%) patients and angiographic guidance was used in the remainder. Minimal lumen diameter was significantly greater in CBA-BMS than BA-BMS (2.65±0.40 mm vs 2.52±0.4 mm, p<0.01) and % diameter stenosis (%DS)-post was less in CBA-BMS than BA-BMS (14.0±5.9% vs 16.3±6.8%, p<0.01). %DS-follow-up was subsequently less in CBA-BMS than BABMS (32.4±15.1% vs 35.4±15.3%, p<0.05) associated with lower rates of restenosis in CBA-BMS than BA-BMS (11.8% vs 19.6%, p<0.05) and less target lesion revascularization (TLR) in CBA-BMS than BA-BMS (9.6% vs 15.3%, p<0.05). Patients were divided into 4 groups based on the device used before stenting and IVUS use (IVUS-CBA-BMS: 137 patients; Angio-CBA-BMS; 123; IVUS-BA-BMS: 142; and Angio-BA-BMS: 119). At follow-up IVUS-CBA-BMS had a significantly lower restenosis rate (6.6%) than Angio-CBA-BMS (17.9%), IVUS-BA-BMS (19.8%) and Angio-BA-BMS (18.2%, p<0.05). Conclusions: Restenosis and TLR were significantly lower in CBA-BMS than BA-BMS. This favorable outcome was achieved because of the lower restenosis rate conferred by the IVUS-guided-CBA-BMS strategy (6.6%). The restenosis rates obtained with this strategy were comparable to those achieved with DES.

UR - http://www.scopus.com/inward/record.url?scp=33846031990&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846031990&partnerID=8YFLogxK

U2 - 10.1253/circj.71.1

DO - 10.1253/circj.71.1

M3 - Article

C2 - 17186970

AN - SCOPUS:33846031990

VL - 71

SP - 1

EP - 8

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 1

ER -