Impact of fasting plasma glucose levels on gastric cancer incidence in a general Japanese population: The Hisayama study

Hajime Yamagata, Yutaka Kiyohara, Shotaro Nakamura, Michiaki Kubo, Yumihiro Tanizaki, Takayuki Matsumoto, Keiichi Tanaka, Isao Kato, Tomoko Shirota, Mitsuo Iida

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE - Several studies have shown associations between diabetes and various types of cancer other than gastric cancer. The aim of this cohort study was to evaluate the impact of fasting plasma glucose (FPG) levels on gastric cancer occurrence. RESEARCH DESIGN AND METHODS - A total of 2,466 Japanese subjects aged a40 years were stratified into three groups according to FPG tertiles (<5.3 mmol/l, low FPG; 5.3-5.8 mmol/l, modest FPG; >5.8 mmol/l, high FPG) and followed up prospectively for 9 years. RESULTS - During the follow-up, 66 subjects experienced gastric cancer. In men, the age-adjusted incidences were significantly higher in the modest-FPG (7.0 per 1,000 person-years, P < 0.05) and high-FPG (7.2, P < 0.05) groups than in the low-FPG group (2.2). In women, the high-FPG group also had a significantly higher age-adjusted incidence of gastric cancer compared with the low-FPG group (2.5 vs. 0.8, P < 0.05). The multivariate analysis with Cox's proportional hazards model revealed that the risks of gastric cancer in the modest-FPG (relative risk [RR] 2.3 [95% CI 1.1-5.0]) and high-FPG (3.1 [1.5-6.4]) groups were significantly higher than that in the low-FPG group, even after adjusting for other comprehensive risk factors, including Helicobacter pylori status, smoking, and dietary factors. However, this FPG-cancer association was observed only among H. pylori-seropositive subjects. CONCLUSIONS - Our findings suggest that a modest increase in FPG is a risk factor for gastric cancer and that hyperglycemia is a possible cofactor increasing the risk posed by Helicobacter pylori infection.

Original languageEnglish
Pages (from-to)789-794
Number of pages6
JournalDiabetes care
Volume28
Issue number4
DOIs
Publication statusPublished - 01-04-2005

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Stomach Neoplasms
Fasting
Glucose
Incidence
Population
Helicobacter pylori
Helicobacter Infections
Proportional Hazards Models
Hyperglycemia
Cohort Studies
Research Design
Multivariate Analysis
Smoking

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

Cite this

Yamagata, Hajime ; Kiyohara, Yutaka ; Nakamura, Shotaro ; Kubo, Michiaki ; Tanizaki, Yumihiro ; Matsumoto, Takayuki ; Tanaka, Keiichi ; Kato, Isao ; Shirota, Tomoko ; Iida, Mitsuo. / Impact of fasting plasma glucose levels on gastric cancer incidence in a general Japanese population : The Hisayama study. In: Diabetes care. 2005 ; Vol. 28, No. 4. pp. 789-794.
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title = "Impact of fasting plasma glucose levels on gastric cancer incidence in a general Japanese population: The Hisayama study",
abstract = "OBJECTIVE - Several studies have shown associations between diabetes and various types of cancer other than gastric cancer. The aim of this cohort study was to evaluate the impact of fasting plasma glucose (FPG) levels on gastric cancer occurrence. RESEARCH DESIGN AND METHODS - A total of 2,466 Japanese subjects aged a40 years were stratified into three groups according to FPG tertiles (<5.3 mmol/l, low FPG; 5.3-5.8 mmol/l, modest FPG; >5.8 mmol/l, high FPG) and followed up prospectively for 9 years. RESULTS - During the follow-up, 66 subjects experienced gastric cancer. In men, the age-adjusted incidences were significantly higher in the modest-FPG (7.0 per 1,000 person-years, P < 0.05) and high-FPG (7.2, P < 0.05) groups than in the low-FPG group (2.2). In women, the high-FPG group also had a significantly higher age-adjusted incidence of gastric cancer compared with the low-FPG group (2.5 vs. 0.8, P < 0.05). The multivariate analysis with Cox's proportional hazards model revealed that the risks of gastric cancer in the modest-FPG (relative risk [RR] 2.3 [95{\%} CI 1.1-5.0]) and high-FPG (3.1 [1.5-6.4]) groups were significantly higher than that in the low-FPG group, even after adjusting for other comprehensive risk factors, including Helicobacter pylori status, smoking, and dietary factors. However, this FPG-cancer association was observed only among H. pylori-seropositive subjects. CONCLUSIONS - Our findings suggest that a modest increase in FPG is a risk factor for gastric cancer and that hyperglycemia is a possible cofactor increasing the risk posed by Helicobacter pylori infection.",
author = "Hajime Yamagata and Yutaka Kiyohara and Shotaro Nakamura and Michiaki Kubo and Yumihiro Tanizaki and Takayuki Matsumoto and Keiichi Tanaka and Isao Kato and Tomoko Shirota and Mitsuo Iida",
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Yamagata, H, Kiyohara, Y, Nakamura, S, Kubo, M, Tanizaki, Y, Matsumoto, T, Tanaka, K, Kato, I, Shirota, T & Iida, M 2005, 'Impact of fasting plasma glucose levels on gastric cancer incidence in a general Japanese population: The Hisayama study', Diabetes care, vol. 28, no. 4, pp. 789-794. https://doi.org/10.2337/diacare.28.4.789

Impact of fasting plasma glucose levels on gastric cancer incidence in a general Japanese population : The Hisayama study. / Yamagata, Hajime; Kiyohara, Yutaka; Nakamura, Shotaro; Kubo, Michiaki; Tanizaki, Yumihiro; Matsumoto, Takayuki; Tanaka, Keiichi; Kato, Isao; Shirota, Tomoko; Iida, Mitsuo.

In: Diabetes care, Vol. 28, No. 4, 01.04.2005, p. 789-794.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of fasting plasma glucose levels on gastric cancer incidence in a general Japanese population

T2 - The Hisayama study

AU - Yamagata, Hajime

AU - Kiyohara, Yutaka

AU - Nakamura, Shotaro

AU - Kubo, Michiaki

AU - Tanizaki, Yumihiro

AU - Matsumoto, Takayuki

AU - Tanaka, Keiichi

AU - Kato, Isao

AU - Shirota, Tomoko

AU - Iida, Mitsuo

PY - 2005/4/1

Y1 - 2005/4/1

N2 - OBJECTIVE - Several studies have shown associations between diabetes and various types of cancer other than gastric cancer. The aim of this cohort study was to evaluate the impact of fasting plasma glucose (FPG) levels on gastric cancer occurrence. RESEARCH DESIGN AND METHODS - A total of 2,466 Japanese subjects aged a40 years were stratified into three groups according to FPG tertiles (<5.3 mmol/l, low FPG; 5.3-5.8 mmol/l, modest FPG; >5.8 mmol/l, high FPG) and followed up prospectively for 9 years. RESULTS - During the follow-up, 66 subjects experienced gastric cancer. In men, the age-adjusted incidences were significantly higher in the modest-FPG (7.0 per 1,000 person-years, P < 0.05) and high-FPG (7.2, P < 0.05) groups than in the low-FPG group (2.2). In women, the high-FPG group also had a significantly higher age-adjusted incidence of gastric cancer compared with the low-FPG group (2.5 vs. 0.8, P < 0.05). The multivariate analysis with Cox's proportional hazards model revealed that the risks of gastric cancer in the modest-FPG (relative risk [RR] 2.3 [95% CI 1.1-5.0]) and high-FPG (3.1 [1.5-6.4]) groups were significantly higher than that in the low-FPG group, even after adjusting for other comprehensive risk factors, including Helicobacter pylori status, smoking, and dietary factors. However, this FPG-cancer association was observed only among H. pylori-seropositive subjects. CONCLUSIONS - Our findings suggest that a modest increase in FPG is a risk factor for gastric cancer and that hyperglycemia is a possible cofactor increasing the risk posed by Helicobacter pylori infection.

AB - OBJECTIVE - Several studies have shown associations between diabetes and various types of cancer other than gastric cancer. The aim of this cohort study was to evaluate the impact of fasting plasma glucose (FPG) levels on gastric cancer occurrence. RESEARCH DESIGN AND METHODS - A total of 2,466 Japanese subjects aged a40 years were stratified into three groups according to FPG tertiles (<5.3 mmol/l, low FPG; 5.3-5.8 mmol/l, modest FPG; >5.8 mmol/l, high FPG) and followed up prospectively for 9 years. RESULTS - During the follow-up, 66 subjects experienced gastric cancer. In men, the age-adjusted incidences were significantly higher in the modest-FPG (7.0 per 1,000 person-years, P < 0.05) and high-FPG (7.2, P < 0.05) groups than in the low-FPG group (2.2). In women, the high-FPG group also had a significantly higher age-adjusted incidence of gastric cancer compared with the low-FPG group (2.5 vs. 0.8, P < 0.05). The multivariate analysis with Cox's proportional hazards model revealed that the risks of gastric cancer in the modest-FPG (relative risk [RR] 2.3 [95% CI 1.1-5.0]) and high-FPG (3.1 [1.5-6.4]) groups were significantly higher than that in the low-FPG group, even after adjusting for other comprehensive risk factors, including Helicobacter pylori status, smoking, and dietary factors. However, this FPG-cancer association was observed only among H. pylori-seropositive subjects. CONCLUSIONS - Our findings suggest that a modest increase in FPG is a risk factor for gastric cancer and that hyperglycemia is a possible cofactor increasing the risk posed by Helicobacter pylori infection.

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