Impact of gender on the prognosis of patients with nonvalvular atrial fibrillation

Hiroshi Inoue, Hirotsugu Atarashi, Ken Okumura, Takeshi Yamashita, Hideki Origasa, Naoko Kumagai, Masayuki Sakurai, Yuichiro Kawamura, Isao Kubota, Kazuo Matsumoto, Yoshiaki Kaneko, Satoshi Ogawa, Yoshifusa Aizawa, Masaomi Chinushi, Itsuo Kodama, Eiichi Watanabe, Yukihiro Koretsune, Yuji Okuyama, Akihiko Shimizu, Osamu Igawa & 4 others Shigenobu Bando, Masahiko Fukatani, Tetsunori Saikawa, Akiko Chishaki

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Abstract

Treatment guidelines for atrial fibrillation (AF) used in Western countries describe female gender as a risk factor for thromboembolic events in patients with nonvalvular AF (NVAF). The present study aimed to determine the impact of gender on prognosis of Japanese patients with NVAF. A subanalysis of 7,406 patients with NVAF (mean age 70 years) who were followed-up prospectively for 2 years was performed using data from the J-RHYTHM registry. The primary end points were thromboembolic events, major hemorrhaging, total mortality, and cardiovascular mortality. Compared with male subjects (n = 5,241), female subjects (n = 2,165) were older and displayed greater prevalences of paroxysmal AF, heart failure, and hypertension but less prevalences of diabetes, previous cerebral infarction, and coronary artery disease. Male and female patients had mean CHADS 2 (Congestive heart failure, Hypertension, Age of 75 years or more, Diabetes mellitus and prior Stroke or transient ischemic attack) scores of 1.6 and 1.8, respectively (p <0.001). Warfarin was given to 87% of male patients and 86% of female patients (p = 0.760), and the 2 genders displayed similar mean international normalized ratio of prothrombin time values at baseline (1.91 vs 1.90, respectively, p = 0.756). Multivariate logistic regression analysis indicated that male gender was an independent risk factor for major hemorrhaging (odds ratio 1.59, 95% confidence interval 1.05 to 2.40, p = 0.027) and all-cause mortality (odds ratio 1.78, 95% confidence interval 1.25 to 2.55, p <0.002) but not for thromboembolic events (odds ratio 1.24, 95% confidence interval 0.83 to 1.86, p = 0.297) or cardiovascular mortality (odds ratio 0.96, 95% confidence interval 0.56 to 1.66, p = 0.893). In conclusion, female gender is not a risk factor for thromboembolic events among Japanese patients with NVAF who were treated mostly with warfarin. However, male gender is a risk factor for major hemorrhaging and all-cause mortality.

Original languageEnglish
Pages (from-to)957-962
Number of pages6
JournalAmerican Journal of Cardiology
Volume113
Issue number6
DOIs
Publication statusPublished - 15-03-2014

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Atrial Fibrillation
Odds Ratio
Mortality
Confidence Intervals
Warfarin
Cerebral Arterial Diseases
Heart Failure
Hypertension
International Normalized Ratio
Prothrombin Time
Transient Ischemic Attack
Cerebral Infarction
Registries
Coronary Artery Disease
Diabetes Mellitus
Logistic Models
Stroke
Regression Analysis
Guidelines

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Inoue, H., Atarashi, H., Okumura, K., Yamashita, T., Origasa, H., Kumagai, N., ... Chishaki, A. (2014). Impact of gender on the prognosis of patients with nonvalvular atrial fibrillation. American Journal of Cardiology, 113(6), 957-962. https://doi.org/10.1016/j.amjcard.2013.11.057
Inoue, Hiroshi ; Atarashi, Hirotsugu ; Okumura, Ken ; Yamashita, Takeshi ; Origasa, Hideki ; Kumagai, Naoko ; Sakurai, Masayuki ; Kawamura, Yuichiro ; Kubota, Isao ; Matsumoto, Kazuo ; Kaneko, Yoshiaki ; Ogawa, Satoshi ; Aizawa, Yoshifusa ; Chinushi, Masaomi ; Kodama, Itsuo ; Watanabe, Eiichi ; Koretsune, Yukihiro ; Okuyama, Yuji ; Shimizu, Akihiko ; Igawa, Osamu ; Bando, Shigenobu ; Fukatani, Masahiko ; Saikawa, Tetsunori ; Chishaki, Akiko. / Impact of gender on the prognosis of patients with nonvalvular atrial fibrillation. In: American Journal of Cardiology. 2014 ; Vol. 113, No. 6. pp. 957-962.
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abstract = "Treatment guidelines for atrial fibrillation (AF) used in Western countries describe female gender as a risk factor for thromboembolic events in patients with nonvalvular AF (NVAF). The present study aimed to determine the impact of gender on prognosis of Japanese patients with NVAF. A subanalysis of 7,406 patients with NVAF (mean age 70 years) who were followed-up prospectively for 2 years was performed using data from the J-RHYTHM registry. The primary end points were thromboembolic events, major hemorrhaging, total mortality, and cardiovascular mortality. Compared with male subjects (n = 5,241), female subjects (n = 2,165) were older and displayed greater prevalences of paroxysmal AF, heart failure, and hypertension but less prevalences of diabetes, previous cerebral infarction, and coronary artery disease. Male and female patients had mean CHADS 2 (Congestive heart failure, Hypertension, Age of 75 years or more, Diabetes mellitus and prior Stroke or transient ischemic attack) scores of 1.6 and 1.8, respectively (p <0.001). Warfarin was given to 87{\%} of male patients and 86{\%} of female patients (p = 0.760), and the 2 genders displayed similar mean international normalized ratio of prothrombin time values at baseline (1.91 vs 1.90, respectively, p = 0.756). Multivariate logistic regression analysis indicated that male gender was an independent risk factor for major hemorrhaging (odds ratio 1.59, 95{\%} confidence interval 1.05 to 2.40, p = 0.027) and all-cause mortality (odds ratio 1.78, 95{\%} confidence interval 1.25 to 2.55, p <0.002) but not for thromboembolic events (odds ratio 1.24, 95{\%} confidence interval 0.83 to 1.86, p = 0.297) or cardiovascular mortality (odds ratio 0.96, 95{\%} confidence interval 0.56 to 1.66, p = 0.893). In conclusion, female gender is not a risk factor for thromboembolic events among Japanese patients with NVAF who were treated mostly with warfarin. However, male gender is a risk factor for major hemorrhaging and all-cause mortality.",
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Inoue, H, Atarashi, H, Okumura, K, Yamashita, T, Origasa, H, Kumagai, N, Sakurai, M, Kawamura, Y, Kubota, I, Matsumoto, K, Kaneko, Y, Ogawa, S, Aizawa, Y, Chinushi, M, Kodama, I, Watanabe, E, Koretsune, Y, Okuyama, Y, Shimizu, A, Igawa, O, Bando, S, Fukatani, M, Saikawa, T & Chishaki, A 2014, 'Impact of gender on the prognosis of patients with nonvalvular atrial fibrillation', American Journal of Cardiology, vol. 113, no. 6, pp. 957-962. https://doi.org/10.1016/j.amjcard.2013.11.057

Impact of gender on the prognosis of patients with nonvalvular atrial fibrillation. / Inoue, Hiroshi; Atarashi, Hirotsugu; Okumura, Ken; Yamashita, Takeshi; Origasa, Hideki; Kumagai, Naoko; Sakurai, Masayuki; Kawamura, Yuichiro; Kubota, Isao; Matsumoto, Kazuo; Kaneko, Yoshiaki; Ogawa, Satoshi; Aizawa, Yoshifusa; Chinushi, Masaomi; Kodama, Itsuo; Watanabe, Eiichi; Koretsune, Yukihiro; Okuyama, Yuji; Shimizu, Akihiko; Igawa, Osamu; Bando, Shigenobu; Fukatani, Masahiko; Saikawa, Tetsunori; Chishaki, Akiko.

In: American Journal of Cardiology, Vol. 113, No. 6, 15.03.2014, p. 957-962.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of gender on the prognosis of patients with nonvalvular atrial fibrillation

AU - Inoue, Hiroshi

AU - Atarashi, Hirotsugu

AU - Okumura, Ken

AU - Yamashita, Takeshi

AU - Origasa, Hideki

AU - Kumagai, Naoko

AU - Sakurai, Masayuki

AU - Kawamura, Yuichiro

AU - Kubota, Isao

AU - Matsumoto, Kazuo

AU - Kaneko, Yoshiaki

AU - Ogawa, Satoshi

AU - Aizawa, Yoshifusa

AU - Chinushi, Masaomi

AU - Kodama, Itsuo

AU - Watanabe, Eiichi

AU - Koretsune, Yukihiro

AU - Okuyama, Yuji

AU - Shimizu, Akihiko

AU - Igawa, Osamu

AU - Bando, Shigenobu

AU - Fukatani, Masahiko

AU - Saikawa, Tetsunori

AU - Chishaki, Akiko

PY - 2014/3/15

Y1 - 2014/3/15

N2 - Treatment guidelines for atrial fibrillation (AF) used in Western countries describe female gender as a risk factor for thromboembolic events in patients with nonvalvular AF (NVAF). The present study aimed to determine the impact of gender on prognosis of Japanese patients with NVAF. A subanalysis of 7,406 patients with NVAF (mean age 70 years) who were followed-up prospectively for 2 years was performed using data from the J-RHYTHM registry. The primary end points were thromboembolic events, major hemorrhaging, total mortality, and cardiovascular mortality. Compared with male subjects (n = 5,241), female subjects (n = 2,165) were older and displayed greater prevalences of paroxysmal AF, heart failure, and hypertension but less prevalences of diabetes, previous cerebral infarction, and coronary artery disease. Male and female patients had mean CHADS 2 (Congestive heart failure, Hypertension, Age of 75 years or more, Diabetes mellitus and prior Stroke or transient ischemic attack) scores of 1.6 and 1.8, respectively (p <0.001). Warfarin was given to 87% of male patients and 86% of female patients (p = 0.760), and the 2 genders displayed similar mean international normalized ratio of prothrombin time values at baseline (1.91 vs 1.90, respectively, p = 0.756). Multivariate logistic regression analysis indicated that male gender was an independent risk factor for major hemorrhaging (odds ratio 1.59, 95% confidence interval 1.05 to 2.40, p = 0.027) and all-cause mortality (odds ratio 1.78, 95% confidence interval 1.25 to 2.55, p <0.002) but not for thromboembolic events (odds ratio 1.24, 95% confidence interval 0.83 to 1.86, p = 0.297) or cardiovascular mortality (odds ratio 0.96, 95% confidence interval 0.56 to 1.66, p = 0.893). In conclusion, female gender is not a risk factor for thromboembolic events among Japanese patients with NVAF who were treated mostly with warfarin. However, male gender is a risk factor for major hemorrhaging and all-cause mortality.

AB - Treatment guidelines for atrial fibrillation (AF) used in Western countries describe female gender as a risk factor for thromboembolic events in patients with nonvalvular AF (NVAF). The present study aimed to determine the impact of gender on prognosis of Japanese patients with NVAF. A subanalysis of 7,406 patients with NVAF (mean age 70 years) who were followed-up prospectively for 2 years was performed using data from the J-RHYTHM registry. The primary end points were thromboembolic events, major hemorrhaging, total mortality, and cardiovascular mortality. Compared with male subjects (n = 5,241), female subjects (n = 2,165) were older and displayed greater prevalences of paroxysmal AF, heart failure, and hypertension but less prevalences of diabetes, previous cerebral infarction, and coronary artery disease. Male and female patients had mean CHADS 2 (Congestive heart failure, Hypertension, Age of 75 years or more, Diabetes mellitus and prior Stroke or transient ischemic attack) scores of 1.6 and 1.8, respectively (p <0.001). Warfarin was given to 87% of male patients and 86% of female patients (p = 0.760), and the 2 genders displayed similar mean international normalized ratio of prothrombin time values at baseline (1.91 vs 1.90, respectively, p = 0.756). Multivariate logistic regression analysis indicated that male gender was an independent risk factor for major hemorrhaging (odds ratio 1.59, 95% confidence interval 1.05 to 2.40, p = 0.027) and all-cause mortality (odds ratio 1.78, 95% confidence interval 1.25 to 2.55, p <0.002) but not for thromboembolic events (odds ratio 1.24, 95% confidence interval 0.83 to 1.86, p = 0.297) or cardiovascular mortality (odds ratio 0.96, 95% confidence interval 0.56 to 1.66, p = 0.893). In conclusion, female gender is not a risk factor for thromboembolic events among Japanese patients with NVAF who were treated mostly with warfarin. However, male gender is a risk factor for major hemorrhaging and all-cause mortality.

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Inoue H, Atarashi H, Okumura K, Yamashita T, Origasa H, Kumagai N et al. Impact of gender on the prognosis of patients with nonvalvular atrial fibrillation. American Journal of Cardiology. 2014 Mar 15;113(6):957-962. https://doi.org/10.1016/j.amjcard.2013.11.057