TY - JOUR
T1 - Impact of Kir6.2 E23K polymorphism on the development of type 2 diabetes in a general Japanese population
T2 - The hisayama study
AU - Doi, Yasufumi
AU - Kubo, Michiaki
AU - Ninomiya, Toshiharu
AU - Yonemoto, Koji
AU - Iwase, Masanori
AU - Arima, Hisatomi
AU - Hata, Jun
AU - Tanizaki, Yumihiro
AU - Iida, Mitsuo
AU - Kiyohara, Yutaka
PY - 2007/11
Y1 - 2007/11
N2 - OBJECTIVE - The association between the E23K polymorphism of ATP-sensitive K+ channel subunit Kir6.2 and diabetes has been reported in Caucasians but not in Asians. We examined this issue in follow-up and cross-sectional studies in a general Japanese population. RESEARCH DESIGN AND METHODS - In a 14-year follow-up study of 976 subjects aged 40-79 years with normal glucose tolerance (NGT), we investigated the impact of the E23K polymorphism on change of glucose tolerance status using a 75-g oral glucose tolerance test. Additionally, we confirmed this association in a cross-sectional survey of 2,862 subjects. RESULTS - In the follow-up study, the frequencies of the K/K genotype or K-allele were significantly higher in subjects with conversion from NGT to diabetes than in those in whom NGT was maintained (genotypes, P = 0.01; alleles, P = 0.008). In multivariate analysis, the risk for progression to diabetes was significantly higher in subjects with the E/K (odds ratio 2.10 [95% CI 1.16-3.83]) and K/K (2.40 [1.01-5.70], P for trend = 0.01) genotypes than in those with the E/E genotype after adjustment for confounding factors, namely, age, sex, fasting plasma glucose, family history of diabetes, BMI, physical activity, current drinking, and current smoking. In the cross-sectional study, the frequencies of the K/K genotype or K-allele were also significantly higher in those with diabetes than in those with NGT (genotypes, P = 0.006; alleles, P = 0.001). CONCLUSIONS - Our findings suggest that the Kir6.2 E23K polymorphism is an independent genetic risk factor for diabetes in the general Japanese population.
AB - OBJECTIVE - The association between the E23K polymorphism of ATP-sensitive K+ channel subunit Kir6.2 and diabetes has been reported in Caucasians but not in Asians. We examined this issue in follow-up and cross-sectional studies in a general Japanese population. RESEARCH DESIGN AND METHODS - In a 14-year follow-up study of 976 subjects aged 40-79 years with normal glucose tolerance (NGT), we investigated the impact of the E23K polymorphism on change of glucose tolerance status using a 75-g oral glucose tolerance test. Additionally, we confirmed this association in a cross-sectional survey of 2,862 subjects. RESULTS - In the follow-up study, the frequencies of the K/K genotype or K-allele were significantly higher in subjects with conversion from NGT to diabetes than in those in whom NGT was maintained (genotypes, P = 0.01; alleles, P = 0.008). In multivariate analysis, the risk for progression to diabetes was significantly higher in subjects with the E/K (odds ratio 2.10 [95% CI 1.16-3.83]) and K/K (2.40 [1.01-5.70], P for trend = 0.01) genotypes than in those with the E/E genotype after adjustment for confounding factors, namely, age, sex, fasting plasma glucose, family history of diabetes, BMI, physical activity, current drinking, and current smoking. In the cross-sectional study, the frequencies of the K/K genotype or K-allele were also significantly higher in those with diabetes than in those with NGT (genotypes, P = 0.006; alleles, P = 0.001). CONCLUSIONS - Our findings suggest that the Kir6.2 E23K polymorphism is an independent genetic risk factor for diabetes in the general Japanese population.
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U2 - 10.2337/db06-1709
DO - 10.2337/db06-1709
M3 - Article
C2 - 17965318
AN - SCOPUS:35748940314
SN - 0012-1797
VL - 56
SP - 2829
EP - 2833
JO - Diabetes
JF - Diabetes
IS - 11
ER -
