Impact of low levels of vascular endothelial growth factor after myocardial infarction on 6-month clinical outcome-results from the Nagoya acute myocardial infarction study

Kyoko Matsudaira, Kengo Maeda, Naoki Okumura, Daiji Yoshikawa, Yasuhiro Morita, Hirotsugu Mitsuhashi, Hideki Ishii, Takahisa Kondo, Toyoaki Murohara

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27 Citations (Scopus)

Abstract

Background: Vascular endothelial growth factor (VEGF) is induced by myocardial ischemia and is thought to facilitate cardiovascular repair after acute myocardial infarction (AMI). However, the association between the plasma VEGF levels and clinical outcome in AMI patients is unclear. Methods and Results: We evaluated 879 AMI patients undergoing successful primary revascularization within 24 h of symptom onset. The patients were classified into 3 groups according to tertiles of plasm a VEGF levels at 7 daysafter the onset of AMI. Major adverse cardiovascular and cerebrovascular events (MACCE), defined as cardiac death, recurrent acute coronary syndrome, hospital readmission for heart failure, or stroke, were assessed during the 6-month follow-up period. The incidence of MACCE was the least frequent in the middle tertile. Compared to the middle tertile, patients in the low tertile were at a significantly higher risk for MACCE even after adjusting for baseline characteristics (hazard ratio [HR] 2.67, 95% confidence interval [CI] 1.18-6.06, P=0.019). An absent ce of statin treatmentbefore onset and a younger age (HR 0.54, 0.87; 95%CI 0.33-0.90, 0.76-0.99; P=0.017, 0.037; respectively) were significantly associated with low VEGF. Conclusions: Low plasma VEGF levels at 7 days after the onset of AMI were associated with a significantly increased risk for MACCE during 6 months of follow-up.

Original languageEnglish
Pages (from-to)1509-1516
Number of pages8
JournalCirculation Journal
Volume76
Issue number6
DOIs
Publication statusPublished - 06-2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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