Impact of Metabolic Syndrome on Tissue Characteristics of Angiographically Mild to Moderate Coronary Lesions. Integrated Backscatter Intravascular Ultrasound Study

Tetsuya Amano, Tatsuaki Matsubara, Tadayuki Uetani, Michio Nanki, Nobuyuki Marui, Masataka Kato, Kosuke Arai, Kiminobu Yokoi, Hirohiko Ando, Hideki Ishii, Hideo Izawa, Toyoaki Murohara

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Objectives: We assessed the impact of metabolic syndrome (MetS) on the tissue characteristics of coronary plaques using integrated backscatter intravascular ultrasound (IB-IVUS). Background: Metabolic syndrome is associated with the increasing risk of cardiovascular disease. Methods: We identified MetS by the definition of the National Cholesterol Education Program in Adult Treatment Panel III criterion. Non-target coronary lesions with mild to moderate stenosis were measured by conventional and IB-IVUS parameters using 40-MHz (motorized pullback 0.5 mm/s) intravascular catheter. A total of 20 IB-IVUS images were recorded at an interval of 0.5 mm for 10 mm length in each plaque. The 3-dimensional analyses were performed using commercially available software. Results: The prevalence of MetS was 61 patients (50%) with 73 lesions (49%) among 122 patients with 148 lesions. Patients with MetS showed a significant increase in percentage lipid area (38 ± 19% vs. 30 ± 19%, p = 0.02) and percentage lipid volume (39 ± 17% vs. 33 ± 17%, p = 0.03), and they also showed a significant decrease in percentage of fibrous volume (57 ± 14% vs. 61 ± 13%, p = 0.03). Multivariate regression analysis after adjustment for potentially confounding risk factors showed that MetS remains correlated independently with the percentage of lipid volume (r = 0.223, p = 0.01). Logistic regression analysis after adjusting for confounding and non-MetS coronary risk factors showed that MetS (odds ratio 4.00, 95% confidence interval 1.33 to 12.0, p = 0.01) is proved to be an independent predictor of the lipid-rich plaque. Conclusions: Metabolic syndrome is associated with lipid-rich plaques, contributing to the increasing risk of plaque vulnerability.

Original languageEnglish
Pages (from-to)1149-1156
Number of pages8
JournalJournal of the American College of Cardiology
Volume49
Issue number11
DOIs
Publication statusPublished - 20-03-2007
Externally publishedYes

Fingerprint

Lipids
Regression Analysis
Pathologic Constriction
Cardiovascular Diseases
Software
Multivariate Analysis
Catheters
Logistic Models
Odds Ratio
Cholesterol
Confidence Intervals
Education
Therapeutics

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Amano, Tetsuya ; Matsubara, Tatsuaki ; Uetani, Tadayuki ; Nanki, Michio ; Marui, Nobuyuki ; Kato, Masataka ; Arai, Kosuke ; Yokoi, Kiminobu ; Ando, Hirohiko ; Ishii, Hideki ; Izawa, Hideo ; Murohara, Toyoaki. / Impact of Metabolic Syndrome on Tissue Characteristics of Angiographically Mild to Moderate Coronary Lesions. Integrated Backscatter Intravascular Ultrasound Study. In: Journal of the American College of Cardiology. 2007 ; Vol. 49, No. 11. pp. 1149-1156.
@article{217373e1071d411590f2d2fc2fd44a49,
title = "Impact of Metabolic Syndrome on Tissue Characteristics of Angiographically Mild to Moderate Coronary Lesions. Integrated Backscatter Intravascular Ultrasound Study",
abstract = "Objectives: We assessed the impact of metabolic syndrome (MetS) on the tissue characteristics of coronary plaques using integrated backscatter intravascular ultrasound (IB-IVUS). Background: Metabolic syndrome is associated with the increasing risk of cardiovascular disease. Methods: We identified MetS by the definition of the National Cholesterol Education Program in Adult Treatment Panel III criterion. Non-target coronary lesions with mild to moderate stenosis were measured by conventional and IB-IVUS parameters using 40-MHz (motorized pullback 0.5 mm/s) intravascular catheter. A total of 20 IB-IVUS images were recorded at an interval of 0.5 mm for 10 mm length in each plaque. The 3-dimensional analyses were performed using commercially available software. Results: The prevalence of MetS was 61 patients (50{\%}) with 73 lesions (49{\%}) among 122 patients with 148 lesions. Patients with MetS showed a significant increase in percentage lipid area (38 ± 19{\%} vs. 30 ± 19{\%}, p = 0.02) and percentage lipid volume (39 ± 17{\%} vs. 33 ± 17{\%}, p = 0.03), and they also showed a significant decrease in percentage of fibrous volume (57 ± 14{\%} vs. 61 ± 13{\%}, p = 0.03). Multivariate regression analysis after adjustment for potentially confounding risk factors showed that MetS remains correlated independently with the percentage of lipid volume (r = 0.223, p = 0.01). Logistic regression analysis after adjusting for confounding and non-MetS coronary risk factors showed that MetS (odds ratio 4.00, 95{\%} confidence interval 1.33 to 12.0, p = 0.01) is proved to be an independent predictor of the lipid-rich plaque. Conclusions: Metabolic syndrome is associated with lipid-rich plaques, contributing to the increasing risk of plaque vulnerability.",
author = "Tetsuya Amano and Tatsuaki Matsubara and Tadayuki Uetani and Michio Nanki and Nobuyuki Marui and Masataka Kato and Kosuke Arai and Kiminobu Yokoi and Hirohiko Ando and Hideki Ishii and Hideo Izawa and Toyoaki Murohara",
year = "2007",
month = "3",
day = "20",
doi = "10.1016/j.jacc.2006.12.028",
language = "English",
volume = "49",
pages = "1149--1156",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Elsevier USA",
number = "11",

}

Impact of Metabolic Syndrome on Tissue Characteristics of Angiographically Mild to Moderate Coronary Lesions. Integrated Backscatter Intravascular Ultrasound Study. / Amano, Tetsuya; Matsubara, Tatsuaki; Uetani, Tadayuki; Nanki, Michio; Marui, Nobuyuki; Kato, Masataka; Arai, Kosuke; Yokoi, Kiminobu; Ando, Hirohiko; Ishii, Hideki; Izawa, Hideo; Murohara, Toyoaki.

In: Journal of the American College of Cardiology, Vol. 49, No. 11, 20.03.2007, p. 1149-1156.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of Metabolic Syndrome on Tissue Characteristics of Angiographically Mild to Moderate Coronary Lesions. Integrated Backscatter Intravascular Ultrasound Study

AU - Amano, Tetsuya

AU - Matsubara, Tatsuaki

AU - Uetani, Tadayuki

AU - Nanki, Michio

AU - Marui, Nobuyuki

AU - Kato, Masataka

AU - Arai, Kosuke

AU - Yokoi, Kiminobu

AU - Ando, Hirohiko

AU - Ishii, Hideki

AU - Izawa, Hideo

AU - Murohara, Toyoaki

PY - 2007/3/20

Y1 - 2007/3/20

N2 - Objectives: We assessed the impact of metabolic syndrome (MetS) on the tissue characteristics of coronary plaques using integrated backscatter intravascular ultrasound (IB-IVUS). Background: Metabolic syndrome is associated with the increasing risk of cardiovascular disease. Methods: We identified MetS by the definition of the National Cholesterol Education Program in Adult Treatment Panel III criterion. Non-target coronary lesions with mild to moderate stenosis were measured by conventional and IB-IVUS parameters using 40-MHz (motorized pullback 0.5 mm/s) intravascular catheter. A total of 20 IB-IVUS images were recorded at an interval of 0.5 mm for 10 mm length in each plaque. The 3-dimensional analyses were performed using commercially available software. Results: The prevalence of MetS was 61 patients (50%) with 73 lesions (49%) among 122 patients with 148 lesions. Patients with MetS showed a significant increase in percentage lipid area (38 ± 19% vs. 30 ± 19%, p = 0.02) and percentage lipid volume (39 ± 17% vs. 33 ± 17%, p = 0.03), and they also showed a significant decrease in percentage of fibrous volume (57 ± 14% vs. 61 ± 13%, p = 0.03). Multivariate regression analysis after adjustment for potentially confounding risk factors showed that MetS remains correlated independently with the percentage of lipid volume (r = 0.223, p = 0.01). Logistic regression analysis after adjusting for confounding and non-MetS coronary risk factors showed that MetS (odds ratio 4.00, 95% confidence interval 1.33 to 12.0, p = 0.01) is proved to be an independent predictor of the lipid-rich plaque. Conclusions: Metabolic syndrome is associated with lipid-rich plaques, contributing to the increasing risk of plaque vulnerability.

AB - Objectives: We assessed the impact of metabolic syndrome (MetS) on the tissue characteristics of coronary plaques using integrated backscatter intravascular ultrasound (IB-IVUS). Background: Metabolic syndrome is associated with the increasing risk of cardiovascular disease. Methods: We identified MetS by the definition of the National Cholesterol Education Program in Adult Treatment Panel III criterion. Non-target coronary lesions with mild to moderate stenosis were measured by conventional and IB-IVUS parameters using 40-MHz (motorized pullback 0.5 mm/s) intravascular catheter. A total of 20 IB-IVUS images were recorded at an interval of 0.5 mm for 10 mm length in each plaque. The 3-dimensional analyses were performed using commercially available software. Results: The prevalence of MetS was 61 patients (50%) with 73 lesions (49%) among 122 patients with 148 lesions. Patients with MetS showed a significant increase in percentage lipid area (38 ± 19% vs. 30 ± 19%, p = 0.02) and percentage lipid volume (39 ± 17% vs. 33 ± 17%, p = 0.03), and they also showed a significant decrease in percentage of fibrous volume (57 ± 14% vs. 61 ± 13%, p = 0.03). Multivariate regression analysis after adjustment for potentially confounding risk factors showed that MetS remains correlated independently with the percentage of lipid volume (r = 0.223, p = 0.01). Logistic regression analysis after adjusting for confounding and non-MetS coronary risk factors showed that MetS (odds ratio 4.00, 95% confidence interval 1.33 to 12.0, p = 0.01) is proved to be an independent predictor of the lipid-rich plaque. Conclusions: Metabolic syndrome is associated with lipid-rich plaques, contributing to the increasing risk of plaque vulnerability.

UR - http://www.scopus.com/inward/record.url?scp=33947185415&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33947185415&partnerID=8YFLogxK

U2 - 10.1016/j.jacc.2006.12.028

DO - 10.1016/j.jacc.2006.12.028

M3 - Article

VL - 49

SP - 1149

EP - 1156

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 11

ER -