Impact of myosteatosis on skeletal muscle volume loss in patients with chronic liver disease

Yoshihiko Tachi, Akihiro Kozuka, Takanori Hirai, Yoji Ishizu, Takashi Honda, Teiji Kuzuya, Kazuhiko Hayashi, Masatoshi Ishigami, Hidemi Goto

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


Background and Aim: Severe muscle volume loss is a recognized negative prognostic factor in patients with chronic liver disease. However, the effect of skeletal muscle fat deposition, referred to as myosteatosis on muscle volume loss remains unclear. The aim of this study was to investigate the relationships between myosteatosis and skeletal muscle volume loss. Methods: We enrolled 362 patients with chronic liver disease (186 men, 176 women; mean age 68.4 ± 10.0 years, 94 with cirrhosis) who underwent liver biopsy and computed tomography scanning between January 2013 and February 2017. A transverse computed tomography image of each scan at the third lumbar vertebra was used to evaluate skeletal muscle tissues. Results: Prevalence of skeletal muscle volume loss and myosteatosis were 36% and 82%, respectively. Of those with skeletal muscle volume loss, 93% have concomitant myosteatosis. Univariate analysis revealed that higher age, female, lower body mass index (BMI), higher serum albumin, lower alanine aminotransferase (ALT), lower gamma-glutamyl transpeptidase, lower total bilirubin, lower α-fetoprotein, lower skeletal muscle attenuation, and liver steatosis were significantly associated with skeletal muscle volume loss. Multivariate logistic regression analysis confirmed that lower BMI (odds ratio [OR] 5.26, 95% confidence interval [CI], 3.21–8.54; P < 0.001), presence of myosteatosis (OR, 2.82; 95% CI, 1.26–6.30; P < 0.001), lower ALT (OR, 2.04; 95% CI, 1.18–3.52; P = 0.010), and female (OR, 1.71; 95% CI, 1.04–2.28; P = 0.034) were significant independent factors associated with skeletal volume loss. Conclusions: Myosteatosis, low BMI, low ALT, and female are associated with skeletal muscle volume loss in patients with chronic liver disease.

Original languageEnglish
Pages (from-to)1659-1666
Number of pages8
JournalJournal of Gastroenterology and Hepatology (Australia)
Issue number9
Publication statusPublished - 09-2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology


Dive into the research topics of 'Impact of myosteatosis on skeletal muscle volume loss in patients with chronic liver disease'. Together they form a unique fingerprint.

Cite this