Impact of peripheral artery disease on prognosis after myocardial infarction: The J-MINUET study

Hirokuni Akahori, Tohru Masuyama, Takahiro Imanaka, Koichi Nakao, Yukio Ozaki, Kazuo Kimura, Junya Ako, Teruo Noguchi, Satoru Suwa, Kazuteru Fujimoto, Yasuharu Nakama, Takashi Morita, Wataru Shimizu, Yoshihiko Saito, Atsushi Hirohata, Yasuhiro Morita, Teruo Inoue, Atsunori Okamura, Toshiaki Mano, Kazuhito HirataKengo Tanabe, Yoshisato Shibata, Mafumi Owa, Kenichi Tsujita, Hiroshi Funayama, Nobuaki Kokubu, Ken Kozuma, Shiro Uemura, Tetsuya Tobaru, Keijiro Saku, Shigeru Oshima, Kunihiro Nishimura, Yoshihiro Miyamoto, Hisao Ogawa, Masaharu Ishihara

Research output: Contribution to journalArticle

Abstract

Background: Patients with peripheral artery disease (PAD) are at high risk of cardiovascular events, including myocardial infarction (MI), stroke, and cardiovascular death. However, the impact of PAD on prognosis in Japanese patients with acute MI remains unclear. Methods: The Japanese registry of acute Myocardial INfarction diagnosed by Universal dEfiniTion (J-MINUET) is a prospective multicenter registry that registered 3283 patients with acute MI. Among them, 2970 patients with available data of PAD were divided into the following 4 groups: 2513 patients without prior MI or PAD (None group), 320 patients with only prior MI (Prior MI group), 100 patients with only PAD (PAD group), and 37 patients with both previous MI and PAD (Both group). The primary endpoint was a composite of all-cause death, non-fatal MI, non-fatal stroke, cardiac failure, and urgent revascularization for unstable angina. Results: The 3-year cumulative incidence of the primary endpoint was 26.9% in None group, 41.4% in Prior MI group, 48.0% in PAD group, and 60.3% in Both group (p < 0.001). In multivariate analysis, hazard ratio using None group as reference was 1.55 (95% confidence intervals 1.25–1.91; p < 0.001) for MI group, 2.26 (1.61–3.07; p < 0.001) for PAD group, and 2.52 (1.52–3.90; p < 0.001) for Both group. Conclusions: Concomitant PAD was associated with poor prognosis in Japanese patients with acute MI.

Original languageEnglish
Pages (from-to)402-406
Number of pages5
JournalJournal of cardiology
Volume76
Issue number4
DOIs
Publication statusPublished - 10-2020

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Akahori, H., Masuyama, T., Imanaka, T., Nakao, K., Ozaki, Y., Kimura, K., Ako, J., Noguchi, T., Suwa, S., Fujimoto, K., Nakama, Y., Morita, T., Shimizu, W., Saito, Y., Hirohata, A., Morita, Y., Inoue, T., Okamura, A., Mano, T., ... Ishihara, M. (2020). Impact of peripheral artery disease on prognosis after myocardial infarction: The J-MINUET study. Journal of cardiology, 76(4), 402-406. https://doi.org/10.1016/j.jjcc.2020.05.014