Impact of plasma aldosterone levels for prediction of in-stent restenosis

Tetsuya Amano, Tatsuaki Matsubara, Hideo Izawa, Masayuki Torigoe, Tomohiro Yoshida, Yukihisa Hamaguchi, Hideki Ishii, Manabu Miura, Yuzo Hayashi, Yasuhiro Ogawa, Toyoaki Murohara

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Aldosterone promotes vascular smooth muscle cell proliferation and endothelial dysfunction, suggesting the contribution to in-stent restenosis (ISR). This study evaluated any relation between plasma aldosterone levels and ISR 6 months after successful coronary stenting. We enrolled 156 consecutive patients with stable angina who underwent coronary bare metal stenting. Plasma aldosterone levels and other serum markers known to influence cardiovascular events were measured in all patients at baseline. Patients with restenosis were found to have significantly higher plasma aldosterone levels than their counterparts without restenosis (162 ± 60 vs 122 ± 60 pg/ml, p = 0.007). On logistic regression analysis, even after adjusting for clinical, angiographic, and other confounding variables, plasma aldosterone level per 10 pg/ml (odds ratio 1.34, 95% confidence interval 1.10 to 1.63, p = 0.006) proved to be the independent predictor of ISR. The area under the receiver-operating characteristic curve for plasma aldosterone level was 0.75, and the optimal cut-off value identified by receiver-operating characteristic analysis was 141.9 pg/ml, which had a predictive accuracy of 69%. In conclusion, the present findings indicate that plasma aldosterone levels at baseline are independent predictors of ISR and may constitute a potential therapeutic target.

Original languageEnglish
Pages (from-to)785-788
Number of pages4
JournalAmerican Journal of Cardiology
Volume97
Issue number6
DOIs
Publication statusPublished - 15-03-2006
Externally publishedYes

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Aldosterone
Stents
ROC Curve
Confounding Factors (Epidemiology)
Stable Angina
Vascular Smooth Muscle
Smooth Muscle Myocytes
Biomarkers
Logistic Models
Metals
Odds Ratio
Regression Analysis
Cell Proliferation
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Amano, T., Matsubara, T., Izawa, H., Torigoe, M., Yoshida, T., Hamaguchi, Y., ... Murohara, T. (2006). Impact of plasma aldosterone levels for prediction of in-stent restenosis. American Journal of Cardiology, 97(6), 785-788. https://doi.org/10.1016/j.amjcard.2005.10.017
Amano, Tetsuya ; Matsubara, Tatsuaki ; Izawa, Hideo ; Torigoe, Masayuki ; Yoshida, Tomohiro ; Hamaguchi, Yukihisa ; Ishii, Hideki ; Miura, Manabu ; Hayashi, Yuzo ; Ogawa, Yasuhiro ; Murohara, Toyoaki. / Impact of plasma aldosterone levels for prediction of in-stent restenosis. In: American Journal of Cardiology. 2006 ; Vol. 97, No. 6. pp. 785-788.
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Amano, T, Matsubara, T, Izawa, H, Torigoe, M, Yoshida, T, Hamaguchi, Y, Ishii, H, Miura, M, Hayashi, Y, Ogawa, Y & Murohara, T 2006, 'Impact of plasma aldosterone levels for prediction of in-stent restenosis', American Journal of Cardiology, vol. 97, no. 6, pp. 785-788. https://doi.org/10.1016/j.amjcard.2005.10.017

Impact of plasma aldosterone levels for prediction of in-stent restenosis. / Amano, Tetsuya; Matsubara, Tatsuaki; Izawa, Hideo; Torigoe, Masayuki; Yoshida, Tomohiro; Hamaguchi, Yukihisa; Ishii, Hideki; Miura, Manabu; Hayashi, Yuzo; Ogawa, Yasuhiro; Murohara, Toyoaki.

In: American Journal of Cardiology, Vol. 97, No. 6, 15.03.2006, p. 785-788.

Research output: Contribution to journalArticle

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T1 - Impact of plasma aldosterone levels for prediction of in-stent restenosis

AU - Amano, Tetsuya

AU - Matsubara, Tatsuaki

AU - Izawa, Hideo

AU - Torigoe, Masayuki

AU - Yoshida, Tomohiro

AU - Hamaguchi, Yukihisa

AU - Ishii, Hideki

AU - Miura, Manabu

AU - Hayashi, Yuzo

AU - Ogawa, Yasuhiro

AU - Murohara, Toyoaki

PY - 2006/3/15

Y1 - 2006/3/15

N2 - Aldosterone promotes vascular smooth muscle cell proliferation and endothelial dysfunction, suggesting the contribution to in-stent restenosis (ISR). This study evaluated any relation between plasma aldosterone levels and ISR 6 months after successful coronary stenting. We enrolled 156 consecutive patients with stable angina who underwent coronary bare metal stenting. Plasma aldosterone levels and other serum markers known to influence cardiovascular events were measured in all patients at baseline. Patients with restenosis were found to have significantly higher plasma aldosterone levels than their counterparts without restenosis (162 ± 60 vs 122 ± 60 pg/ml, p = 0.007). On logistic regression analysis, even after adjusting for clinical, angiographic, and other confounding variables, plasma aldosterone level per 10 pg/ml (odds ratio 1.34, 95% confidence interval 1.10 to 1.63, p = 0.006) proved to be the independent predictor of ISR. The area under the receiver-operating characteristic curve for plasma aldosterone level was 0.75, and the optimal cut-off value identified by receiver-operating characteristic analysis was 141.9 pg/ml, which had a predictive accuracy of 69%. In conclusion, the present findings indicate that plasma aldosterone levels at baseline are independent predictors of ISR and may constitute a potential therapeutic target.

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