Impact of post-dilatation on longitudinal stent elongation: An in vitro study

Takuya Sumi, Hideki Ishii, Akihito Tanaka, Susumu Suzuki, Hiroki Kojima, Naoki Iwakawa, Toshijiro Aoki, Kenshi Hirayama, Takayuki Mitsuda, Kazuhiro Harada, Yosuke Negishi, Tomoyuki Ota, Kenji Kada, Toyoaki Murohara

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Objectives: To evaluate whether balloon inflation for post-dilatation causes longitudinal stent deformation (LSD). Methods and results: Two stents, sized 2.5 mm × 28 mm and 3.5 mm × 28 mm (Nobori ® , biodegradable polymer biolimus-eluting stent; Ultimaster ® , biodegradable polymer sirolimus-eluting stent; Terumo Co., Tokyo, Japan), were deployed at nominal pressure in straight and tapered silicon vessel models. Then, post-dilatation was performed in two ways: dilatation from the distal (D-P group) or proximal (P-D group) side of the stent. Microscopic findings showed that the stents were elongated during every step of the procedure regardless of the post-dilatation method and type of vessel model. The D-P group showed linear elongation during each step of post-dilatation (straight model: 28.7 ± 0.3 mm vs. 29.9 ± 0.3 mm, p = 0.002; tapered model: 28.0 ± 0.1 mm vs. 29.9 ± 0.1 mm, p < 0.001). In contrast, in the P-D group, the most significant change was observed in the first step of post-dilatation and only slight changes were observed thereafter (straight model: 28.6 ± 0.1 mm vs. 29.5 ± 0.1 mm, p < 0.001; tapered model: 28.2 ± 0.1 mm vs. 29.5 ± 0.1 mm, p < 0.001). Optical frequency domain imaging analysis showed that the frequency of stent strut malapposition was positively correlated with the percentage change in stent length (r = 0.74, p < 0.0001). Conclusion: LSD was observed during every step of post-dilatation in both the straight and tapered vessel models. However, some differences were observed between the D-P and P-D groups. Minimizing stent strut malapposition may reduce the risk of LSD.

Original languageEnglish
Pages (from-to)464-470
Number of pages7
JournalJournal of cardiology
Volume71
Issue number5
DOIs
Publication statusPublished - 05-2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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