Impact of PSCA Variation on Gastric Ulcer Susceptibility

Chizu Tanikawa, Keitaro Matsuo, Michiaki Kubo, Atsushi Takahashi, Hidemi Ito, Hideo Tanaka, Yasushi Yatabe, Kenji Yamao, Naoyuki Kamatani, Kazuo Tajima, Yusuke Nakamura, Koichi Matsuda

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Peptic ulcer is one of the most common gastrointestinal disorders with complex etiology. Recently we conducted the genome wide association study for duodenal ulcer and identified disease susceptibility variations at two genetic loci corresponding to the Prostate stem cell antigen (PSCA) gene and the ABO blood group (ABO) gene. Here we investigated the association of these variations with gastric ulcer in two Japanese case-control sample sets, a total of 4,291 gastric ulcer cases and 22,665 controls. As a result, a C-allele of rs2294008 at PSCA increased the risk of gastric ulcer with odds ratio (OR) of 1.13 (P value of 5.85×10 -7 ) in an additive model. On the other hand, SNP rs505922 on ABO exhibited inconsistent result between two cohorts. Our finding implies presence of the common genetic variant in the pathogenesis of gastric and duodenal ulcers.

Original languageEnglish
Article numbere63698
JournalPloS one
Volume8
Issue number5
DOIs
Publication statusPublished - 21-05-2013

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Tanikawa, C., Matsuo, K., Kubo, M., Takahashi, A., Ito, H., Tanaka, H., Yatabe, Y., Yamao, K., Kamatani, N., Tajima, K., Nakamura, Y., & Matsuda, K. (2013). Impact of PSCA Variation on Gastric Ulcer Susceptibility. PloS one, 8(5), [e63698]. https://doi.org/10.1371/journal.pone.0063698