TY - JOUR
T1 - Impact of recipient age and preoperative fasting blood glucose level as the risk factors of living donor liver transplantation in cirrhotic patients in the recent comprehensive era with knowledge of indications
T2 - Recent status in a Japanese single center
AU - Ishigami, Masatoshi
AU - Onishi, Yasuharu
AU - Kamei, Hideya
AU - Kiuchi, Tetsuya
AU - Katano, Yoshiaki
AU - Itoh, Akihiro
AU - Hirooka, Yoshiki
AU - Goto, Hidemi
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013/11
Y1 - 2013/11
N2 - Aim: Recently, knowledge for indications of living donor liver transplantation (LDLT) has been robustly accumulated in. For further improvement, risks should be reexamined in recent cases. In this study, we investigated preoperative risk factors in cirrhotic patients who underwent LDLT in recent era. Methods: Seventy-four cirrhotic patients who underwent LDLT at our institution between 2003 and 2011 were included. Recipient and donor age and sex, existence of hepatocellular carcinoma (HCC), preoperative Model for End-Stage Liver Disease score, fasting blood glucose (FBG), triglyceride, total cholesterol, serum creatinine, hemoglobin A1c, graft:recipient weight ratio, ABO compatibility and choice of calcineurin inhibitor were analyzed. A proportional hazard model was applied and P<0.05 was considered statistically significant. Results: In multivariate analysis, recipient age (hazard ratio=1.188, P=0.011) and FBG (hazard ratio=1.009, P=0.016) showed as significant independent factors. Theoretical mortalities were 9.2%, 21.9% and 51.7% in patients with normal FBG at 55, 60 and 65 years old, respectively, and 34.3% and 53.6% in patients with FBG of 150 and 200mg/dL, respectively, at 60 years old. Conclusion: Recipient age and FBG remain important risk factors for LDLT in cirrhotic patients even in the recent era. These factors should be considered for selecting liver transplant candidates in cirrhotic patients.
AB - Aim: Recently, knowledge for indications of living donor liver transplantation (LDLT) has been robustly accumulated in. For further improvement, risks should be reexamined in recent cases. In this study, we investigated preoperative risk factors in cirrhotic patients who underwent LDLT in recent era. Methods: Seventy-four cirrhotic patients who underwent LDLT at our institution between 2003 and 2011 were included. Recipient and donor age and sex, existence of hepatocellular carcinoma (HCC), preoperative Model for End-Stage Liver Disease score, fasting blood glucose (FBG), triglyceride, total cholesterol, serum creatinine, hemoglobin A1c, graft:recipient weight ratio, ABO compatibility and choice of calcineurin inhibitor were analyzed. A proportional hazard model was applied and P<0.05 was considered statistically significant. Results: In multivariate analysis, recipient age (hazard ratio=1.188, P=0.011) and FBG (hazard ratio=1.009, P=0.016) showed as significant independent factors. Theoretical mortalities were 9.2%, 21.9% and 51.7% in patients with normal FBG at 55, 60 and 65 years old, respectively, and 34.3% and 53.6% in patients with FBG of 150 and 200mg/dL, respectively, at 60 years old. Conclusion: Recipient age and FBG remain important risk factors for LDLT in cirrhotic patients even in the recent era. These factors should be considered for selecting liver transplant candidates in cirrhotic patients.
UR - http://www.scopus.com/inward/record.url?scp=84886839786&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886839786&partnerID=8YFLogxK
U2 - 10.1111/hepr.12067
DO - 10.1111/hepr.12067
M3 - Article
AN - SCOPUS:84886839786
VL - 43
SP - 1148
EP - 1155
JO - Hepatology Research
JF - Hepatology Research
SN - 1386-6346
IS - 11
ER -