TY - JOUR
T1 - Impact of renal function on coronary plaque composition
AU - Miyagi, Motohiro
AU - Ishii, Hideki
AU - Murakami, Ryuichiro
AU - Isobe, Satoshi
AU - Hayashi, Mutsuharu
AU - Amano, Tetsuya
AU - Arai, Kosuke
AU - Yoshikawa, Daiji
AU - Ohashi, Taiki
AU - Uetani, Tadayuki
AU - Yasuda, Yoshinari
AU - Matsuo, Seiichi
AU - Matsubara, Tatsuaki
AU - Murohara, Toyoaki
N1 - Funding Information:
Acknowledgements. This study was supported by a grant from Aichi Kidney Foundation and Grant-in-Aid for Scientific Research (KAKENHI) (No. 20790522) of the Ministry of Education, Culture, Sports, Science and Technology (MEXT) and Japanese Society for the Promotion of Science (JSPA).
PY - 2010/1
Y1 - 2010/1
N2 - Background. Recent studies have demonstrated that patients with chronic kidney disease are at high risk of atherosclerosis. Recently it has been found that coronary plaque components can be evaluated by integrated backscatter intravascular ultrasound (IB-IVUS), and lipid-rich plaque is associated with vulnerable plaque. The aim of the study was to investigate the relationship between renal function and tissue characterization of coronary plaque composition at the target stenotic site for percutaneous coronary intervention (PCI).Methods. We prospectively performed IB-IVUS before elective PCI in 89 consecutive patients with stable angina. According to estimated glomerular filtration rate (eGFR), they were divided into two groups (eGFR <60 mlmin 1.73 m2 or eGFR ≥60 mlmin1.73 m2). The tissue characteristics of the coronary plaque at each target stenotic site were evaluated by three-dimensional (3D) IB-IVUS just before PCI procedure.Results. The patients with eGFR <60 mlmin1.73 m2 had higher percentage of lipid volume and lower percentage of fibrous volume compared to the patients with eGFR ≥ 60 mlmin1.73 m2 on the 3D IB-IVUS images (36.7 ± 10.6 versus 28.7 ± 9.3, P < 0.001 and 59.1 ± 8.7 versus 66.3 ± 8.3, P < 0.001, respectively). eGFR showed a significant negative correlation with lipid volume and had a significant positive correlation with fibrous volume in coronary plaques (r = -0.44, P < 0.0001, and r = 0.46, P < 0.0001, respectively).Conclusions. Impaired renal function was related to higher percentage of lipid volume and lower percentage of fibrous volume in coronary plaque. Our findings may explain the increasing risk of cardiovascular events in patients with renal dysfunction.
AB - Background. Recent studies have demonstrated that patients with chronic kidney disease are at high risk of atherosclerosis. Recently it has been found that coronary plaque components can be evaluated by integrated backscatter intravascular ultrasound (IB-IVUS), and lipid-rich plaque is associated with vulnerable plaque. The aim of the study was to investigate the relationship between renal function and tissue characterization of coronary plaque composition at the target stenotic site for percutaneous coronary intervention (PCI).Methods. We prospectively performed IB-IVUS before elective PCI in 89 consecutive patients with stable angina. According to estimated glomerular filtration rate (eGFR), they were divided into two groups (eGFR <60 mlmin 1.73 m2 or eGFR ≥60 mlmin1.73 m2). The tissue characteristics of the coronary plaque at each target stenotic site were evaluated by three-dimensional (3D) IB-IVUS just before PCI procedure.Results. The patients with eGFR <60 mlmin1.73 m2 had higher percentage of lipid volume and lower percentage of fibrous volume compared to the patients with eGFR ≥ 60 mlmin1.73 m2 on the 3D IB-IVUS images (36.7 ± 10.6 versus 28.7 ± 9.3, P < 0.001 and 59.1 ± 8.7 versus 66.3 ± 8.3, P < 0.001, respectively). eGFR showed a significant negative correlation with lipid volume and had a significant positive correlation with fibrous volume in coronary plaques (r = -0.44, P < 0.0001, and r = 0.46, P < 0.0001, respectively).Conclusions. Impaired renal function was related to higher percentage of lipid volume and lower percentage of fibrous volume in coronary plaque. Our findings may explain the increasing risk of cardiovascular events in patients with renal dysfunction.
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U2 - 10.1093/ndt/gfp423
DO - 10.1093/ndt/gfp423
M3 - Article
C2 - 19703834
AN - SCOPUS:72949092888
SN - 0931-0509
VL - 25
SP - 175
EP - 181
JO - Nephrology Dialysis Transplantation
JF - Nephrology Dialysis Transplantation
IS - 1
ER -