TY - JOUR
T1 - Impact of resection for ovarian metastases from colorectal cancer and clinicopathologic analysis
T2 - A multicenter retrospective study in Japan
AU - Kagawa, Hiroyasu
AU - Kinugasa, Yusuke
AU - Yamaguchi, Tomohiro
AU - Ohue, Masayuki
AU - Kawai, Kazushige
AU - Hiro, Junichiro
AU - Shinji, Seiichi
AU - Nozawa, Hiroaki
AU - Hirano, Yasumitsu
AU - Komori, Koji
AU - Takii, Yasumasa
AU - Suto, Takeshi
AU - Tsukamoto, Shunsuke
AU - Akagi, Yoshito
AU - Ozawa, Heita
AU - Toiyama, Yuji
AU - Minami, Kazuhito
AU - Shimizu, Tomoharu
AU - Uehara, Kay
AU - Sakamoto, Kazuhiro
AU - Mori, Keita
AU - Sugihara, Kenichi
AU - Ajioka, Yoichi
N1 - Publisher Copyright:
© 2023 The Authors. Annals of Gastroenterological Surgery published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Gastroenterological Surgery.
PY - 2024/3
Y1 - 2024/3
N2 - Aim: The aim of this study was to clarify the significance of resection of ovarian metastases from colorectal cancer and to identify the clinicopathologic characteristics. Methods: In this multicenter retrospective study, we evaluated data on ovarian metastases from colorectal cancer obtained from patients at 20 centers in Japan between 2000 and 2014. We examined the impact of resection on the prognosis of patients with ovarian metastases and examined prognostic factors. Results: The study included 296 patients with ovarian metastasis. The 3-y overall survival rate was 68.6% for solitary ovarian metastases. In all cases of this cohort, the 3-y overall survival rates after curative resection, noncurative resection, and nonresection were 65.9%, 31.8%, and 6.1%, respectively (curative resection vs noncurative resection [P < 0.01] and noncurative resection vs nonresection [P < 0.01]). In the multivariate analysis of prognostic factors, tumor size of ovarian metastasis (P < 0.01), bilateral ovarian metastasis (P = 0.01), peritoneal metastasis (P < 0.01), pulmonary metastasis (P = 0.04), liver metastasis (P < 0.01), and remnant of ovarian metastasis (P < 0.01) were statistically significantly different. Conclusion: The prognosis after curative resection for solitary ovarian metastases was shown to be relatively favorable as Stage IV colorectal cancer. Resection of ovarian metastases, not only curative resection but also noncurative resection, confers a survival benefit. Prognostic factors were large ovarian metastases, bilateral ovarian metastases, the presence of extraovarian metastases, and remnant ovarian metastases.
AB - Aim: The aim of this study was to clarify the significance of resection of ovarian metastases from colorectal cancer and to identify the clinicopathologic characteristics. Methods: In this multicenter retrospective study, we evaluated data on ovarian metastases from colorectal cancer obtained from patients at 20 centers in Japan between 2000 and 2014. We examined the impact of resection on the prognosis of patients with ovarian metastases and examined prognostic factors. Results: The study included 296 patients with ovarian metastasis. The 3-y overall survival rate was 68.6% for solitary ovarian metastases. In all cases of this cohort, the 3-y overall survival rates after curative resection, noncurative resection, and nonresection were 65.9%, 31.8%, and 6.1%, respectively (curative resection vs noncurative resection [P < 0.01] and noncurative resection vs nonresection [P < 0.01]). In the multivariate analysis of prognostic factors, tumor size of ovarian metastasis (P < 0.01), bilateral ovarian metastasis (P = 0.01), peritoneal metastasis (P < 0.01), pulmonary metastasis (P = 0.04), liver metastasis (P < 0.01), and remnant of ovarian metastasis (P < 0.01) were statistically significantly different. Conclusion: The prognosis after curative resection for solitary ovarian metastases was shown to be relatively favorable as Stage IV colorectal cancer. Resection of ovarian metastases, not only curative resection but also noncurative resection, confers a survival benefit. Prognostic factors were large ovarian metastases, bilateral ovarian metastases, the presence of extraovarian metastases, and remnant ovarian metastases.
KW - colorectal cancer
KW - ovarian metastasis
KW - ovarian resection
KW - peritoneal metastasis
KW - prognostic factor
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U2 - 10.1002/ags3.12740
DO - 10.1002/ags3.12740
M3 - Article
AN - SCOPUS:85171202093
SN - 2475-0328
VL - 8
SP - 273
EP - 283
JO - Annals of Gastroenterological Surgery
JF - Annals of Gastroenterological Surgery
IS - 2
ER -
