Impact of sitagliptin on carotid intima-media thickness in patients with coronary artery disease and impaired glucose tolerance or mild diabetes mellitus

Shinji Ishikawa, Masayuki Shimano, Masato Watarai, Masayoshi Koyasu, Tomohiro Uchikawa, Hideki Ishii, Yasuya Inden, Kenji Takemoto, Toyoaki Murohara

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Sitagliptin has been widely used for the treatment of diabetes and shown recently to have beneficial pleiotropic outcomes on cardiovascular systems in experimental studies. However, little is known about the influence of sitagliptin on atherosclerosis-related cardiovascular diseases in a clinical setting. This study examined the effect of sitagliptin on carotid intima-media thickness (IMT). A total of 76 patients with clinically stable and documented coronary artery disease, who were newly diagnosed with impaired glucose tolerance or mild type 2 diabetes mellitus, were allocated, randomly, to receive either sitagliptin 100 mg/day or the placebo control. Common carotid IMT, glucose profiles, glycosylated hemoglobin (HbA1c), and lipid profiles were measured at baseline and repeated at 12 months. Sitagliptin-treated patients showed less IMT progression than the control group (p = 0.02). In addition, the sitagliptin group showed greater reductions in body weight (2.2%), 2-hour glucose levels on the 75-g oral glucose tolerance test (17.3%), HbA 1c (4.7%), and low-density lipoprotein cholesterol levels (7.9%) from that at baseline. In conclusion, treatment with sitagliptin for 12 months was associated with a beneficial effect in the prevention of carotid IMT progression, compared with the diet control.

Original languageEnglish
Pages (from-to)384-388
Number of pages5
JournalAmerican Journal of Cardiology
Volume114
Issue number3
DOIs
Publication statusPublished - 01-08-2014

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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