Impact of total risk management on coronary plaque regression in diabetic patients with acute coronary syndrome

Ryo Naito, Katsumi Miyauchi, Hiroyuki Daida, Takeshi Morimoto, Takafumi Hiro, Takeshi Kimura, Yoshihisa Nakagawa, Masakazu Yamagishi, Yukio Ozaki, Masunori Matsuzaki

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Aim: Diabetic patients with coronary artery disease have a high incidence of cardiovascular events, which was associated with increased coronary plaque volume. Low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP) play pivotal roles in the progression of coronary plaque. Several trials have shown that intervention for a single risk factor reduced the development of coronary plaque progression. However, it remained uncertain whether total risk management for LDL-C, BP, and glycosylated Hb (HbA1c) has a beneficial effect on coronary plaque volume in diabetic patients. Methods: This study was a sub-study of the JAPAN-ACS that was a prospective, randomized, openlabel trial that evaluated the impact of intensive lipid-lowering therapy on coronary plaque volume in patients with acute coronary syndrome (ACS). Among a total of 252 patients, 73 diabetic patients were analyzed. We examined the impact of total risk management (LDL-C <80 mg/dL, systolic BP <130 mmHg, and HbA1c <6.5%) on changes in coronary plaque volume. The patients were divided into four groups according to the number of risk factors that achieved the target value. Results: Baseline characteristics were similar among the groups. The degree of coronary plaque regression was greater in patients who achieved total risk management. The number of risk factors that achieved the target level was associated with the extent of the coronary plaque volume reduction in a dose-dependent manner. Conclusion: Total risk management that focused on LDL-C, BP, and HbA1c had a beneficial impact on the coronary plaque regression in diabetic patients with ACS.

Original languageEnglish
Pages (from-to)922-931
Number of pages10
JournalJournal of atherosclerosis and thrombosis
Volume23
Issue number8
DOIs
Publication statusPublished - 01-01-2016

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Blood pressure
Risk Management
Acute Coronary Syndrome
Risk management
LDL Cholesterol
Blood Pressure
Lipids
Coronary Artery Disease
Incidence

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

Cite this

Naito, Ryo ; Miyauchi, Katsumi ; Daida, Hiroyuki ; Morimoto, Takeshi ; Hiro, Takafumi ; Kimura, Takeshi ; Nakagawa, Yoshihisa ; Yamagishi, Masakazu ; Ozaki, Yukio ; Matsuzaki, Masunori. / Impact of total risk management on coronary plaque regression in diabetic patients with acute coronary syndrome. In: Journal of atherosclerosis and thrombosis. 2016 ; Vol. 23, No. 8. pp. 922-931.
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abstract = "Aim: Diabetic patients with coronary artery disease have a high incidence of cardiovascular events, which was associated with increased coronary plaque volume. Low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP) play pivotal roles in the progression of coronary plaque. Several trials have shown that intervention for a single risk factor reduced the development of coronary plaque progression. However, it remained uncertain whether total risk management for LDL-C, BP, and glycosylated Hb (HbA1c) has a beneficial effect on coronary plaque volume in diabetic patients. Methods: This study was a sub-study of the JAPAN-ACS that was a prospective, randomized, openlabel trial that evaluated the impact of intensive lipid-lowering therapy on coronary plaque volume in patients with acute coronary syndrome (ACS). Among a total of 252 patients, 73 diabetic patients were analyzed. We examined the impact of total risk management (LDL-C <80 mg/dL, systolic BP <130 mmHg, and HbA1c <6.5{\%}) on changes in coronary plaque volume. The patients were divided into four groups according to the number of risk factors that achieved the target value. Results: Baseline characteristics were similar among the groups. The degree of coronary plaque regression was greater in patients who achieved total risk management. The number of risk factors that achieved the target level was associated with the extent of the coronary plaque volume reduction in a dose-dependent manner. Conclusion: Total risk management that focused on LDL-C, BP, and HbA1c had a beneficial impact on the coronary plaque regression in diabetic patients with ACS.",
author = "Ryo Naito and Katsumi Miyauchi and Hiroyuki Daida and Takeshi Morimoto and Takafumi Hiro and Takeshi Kimura and Yoshihisa Nakagawa and Masakazu Yamagishi and Yukio Ozaki and Masunori Matsuzaki",
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Naito, R, Miyauchi, K, Daida, H, Morimoto, T, Hiro, T, Kimura, T, Nakagawa, Y, Yamagishi, M, Ozaki, Y & Matsuzaki, M 2016, 'Impact of total risk management on coronary plaque regression in diabetic patients with acute coronary syndrome', Journal of atherosclerosis and thrombosis, vol. 23, no. 8, pp. 922-931. https://doi.org/10.5551/jat.31948

Impact of total risk management on coronary plaque regression in diabetic patients with acute coronary syndrome. / Naito, Ryo; Miyauchi, Katsumi; Daida, Hiroyuki; Morimoto, Takeshi; Hiro, Takafumi; Kimura, Takeshi; Nakagawa, Yoshihisa; Yamagishi, Masakazu; Ozaki, Yukio; Matsuzaki, Masunori.

In: Journal of atherosclerosis and thrombosis, Vol. 23, No. 8, 01.01.2016, p. 922-931.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of total risk management on coronary plaque regression in diabetic patients with acute coronary syndrome

AU - Naito, Ryo

AU - Miyauchi, Katsumi

AU - Daida, Hiroyuki

AU - Morimoto, Takeshi

AU - Hiro, Takafumi

AU - Kimura, Takeshi

AU - Nakagawa, Yoshihisa

AU - Yamagishi, Masakazu

AU - Ozaki, Yukio

AU - Matsuzaki, Masunori

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Aim: Diabetic patients with coronary artery disease have a high incidence of cardiovascular events, which was associated with increased coronary plaque volume. Low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP) play pivotal roles in the progression of coronary plaque. Several trials have shown that intervention for a single risk factor reduced the development of coronary plaque progression. However, it remained uncertain whether total risk management for LDL-C, BP, and glycosylated Hb (HbA1c) has a beneficial effect on coronary plaque volume in diabetic patients. Methods: This study was a sub-study of the JAPAN-ACS that was a prospective, randomized, openlabel trial that evaluated the impact of intensive lipid-lowering therapy on coronary plaque volume in patients with acute coronary syndrome (ACS). Among a total of 252 patients, 73 diabetic patients were analyzed. We examined the impact of total risk management (LDL-C <80 mg/dL, systolic BP <130 mmHg, and HbA1c <6.5%) on changes in coronary plaque volume. The patients were divided into four groups according to the number of risk factors that achieved the target value. Results: Baseline characteristics were similar among the groups. The degree of coronary plaque regression was greater in patients who achieved total risk management. The number of risk factors that achieved the target level was associated with the extent of the coronary plaque volume reduction in a dose-dependent manner. Conclusion: Total risk management that focused on LDL-C, BP, and HbA1c had a beneficial impact on the coronary plaque regression in diabetic patients with ACS.

AB - Aim: Diabetic patients with coronary artery disease have a high incidence of cardiovascular events, which was associated with increased coronary plaque volume. Low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP) play pivotal roles in the progression of coronary plaque. Several trials have shown that intervention for a single risk factor reduced the development of coronary plaque progression. However, it remained uncertain whether total risk management for LDL-C, BP, and glycosylated Hb (HbA1c) has a beneficial effect on coronary plaque volume in diabetic patients. Methods: This study was a sub-study of the JAPAN-ACS that was a prospective, randomized, openlabel trial that evaluated the impact of intensive lipid-lowering therapy on coronary plaque volume in patients with acute coronary syndrome (ACS). Among a total of 252 patients, 73 diabetic patients were analyzed. We examined the impact of total risk management (LDL-C <80 mg/dL, systolic BP <130 mmHg, and HbA1c <6.5%) on changes in coronary plaque volume. The patients were divided into four groups according to the number of risk factors that achieved the target value. Results: Baseline characteristics were similar among the groups. The degree of coronary plaque regression was greater in patients who achieved total risk management. The number of risk factors that achieved the target level was associated with the extent of the coronary plaque volume reduction in a dose-dependent manner. Conclusion: Total risk management that focused on LDL-C, BP, and HbA1c had a beneficial impact on the coronary plaque regression in diabetic patients with ACS.

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DO - 10.5551/jat.31948

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