Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene

Yuka Yasuda, Ryota Hashimoto, Kazutaka Ohi, Motoyuki Fukumoto, Satomi Umeda-Yano, Hidenaga Yamamori, Tomo Okochi, Masao Iwase, Hiroaki Kazui, Nakao Iwata, Masatoshi Takeda

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Schizophrenia is a complex disorder with a high heritability. Relatives with schizophrenia have an increased risk not only for schizophrenia but also for schizophrenia spectrum disorders, such as schizotypal personality disorder. A single nucleotide polymorphism (SNP), rs1344706, in the Zinc Finger Protein 804A (ZNF804A) gene, has been implicated in susceptibility to schizophrenia by several genome-wide association studies, follow-up association studies and meta-analyses. This SNP has been shown to affect neuronal connectivities and cognitive abilities. We investigated an association between the ZNF804A genotype of rs1344706 and schizotypal personality traits using the Schizotypal Personality Questionnaire (SPQ) in 176 healthy subjects. We also looked for specific associations among ZNF804A polymorphisms and the three factors of schizotypy-cognitive/perceptual, interpersonal and disorganization-assessed by the SPQ. The total score for the SPQ in carriers of the risk T allele was significantly higher than that in individuals with the G/G genotype (p= 0.042). For the three factors derived from the SPQ, carriers with the risk T allele showed a higher disorganization factor (p= 0.011), but there were no differences in the cognitive/perceptual or interpersonal factors between genotype groups (p> 0.30). These results suggest that the genetic variation in ZNF804A might increase susceptibility not only for schizophrenia but also for schizotypal personality traits in healthy subjects.

Original languageEnglish
Pages (from-to)216-220
Number of pages5
JournalNeuroscience Letters
Volume495
Issue number3
DOIs
Publication statusPublished - 20-05-2011

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Zinc Fingers
Psychotic Disorders
Personality
Schizophrenia
Genome
Proteins
Genotype
Single Nucleotide Polymorphism
Healthy Volunteers
Alleles
Schizotypal Personality Disorder
Aptitude
Genome-Wide Association Study
Meta-Analysis
Surveys and Questionnaires

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Yasuda, Y., Hashimoto, R., Ohi, K., Fukumoto, M., Umeda-Yano, S., Yamamori, H., ... Takeda, M. (2011). Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene. Neuroscience Letters, 495(3), 216-220. https://doi.org/10.1016/j.neulet.2011.03.069
Yasuda, Yuka ; Hashimoto, Ryota ; Ohi, Kazutaka ; Fukumoto, Motoyuki ; Umeda-Yano, Satomi ; Yamamori, Hidenaga ; Okochi, Tomo ; Iwase, Masao ; Kazui, Hiroaki ; Iwata, Nakao ; Takeda, Masatoshi. / Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene. In: Neuroscience Letters. 2011 ; Vol. 495, No. 3. pp. 216-220.
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Yasuda, Y, Hashimoto, R, Ohi, K, Fukumoto, M, Umeda-Yano, S, Yamamori, H, Okochi, T, Iwase, M, Kazui, H, Iwata, N & Takeda, M 2011, 'Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene', Neuroscience Letters, vol. 495, no. 3, pp. 216-220. https://doi.org/10.1016/j.neulet.2011.03.069

Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene. / Yasuda, Yuka; Hashimoto, Ryota; Ohi, Kazutaka; Fukumoto, Motoyuki; Umeda-Yano, Satomi; Yamamori, Hidenaga; Okochi, Tomo; Iwase, Masao; Kazui, Hiroaki; Iwata, Nakao; Takeda, Masatoshi.

In: Neuroscience Letters, Vol. 495, No. 3, 20.05.2011, p. 216-220.

Research output: Contribution to journalArticle

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T1 - Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene

AU - Yasuda, Yuka

AU - Hashimoto, Ryota

AU - Ohi, Kazutaka

AU - Fukumoto, Motoyuki

AU - Umeda-Yano, Satomi

AU - Yamamori, Hidenaga

AU - Okochi, Tomo

AU - Iwase, Masao

AU - Kazui, Hiroaki

AU - Iwata, Nakao

AU - Takeda, Masatoshi

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Y1 - 2011/5/20

N2 - Schizophrenia is a complex disorder with a high heritability. Relatives with schizophrenia have an increased risk not only for schizophrenia but also for schizophrenia spectrum disorders, such as schizotypal personality disorder. A single nucleotide polymorphism (SNP), rs1344706, in the Zinc Finger Protein 804A (ZNF804A) gene, has been implicated in susceptibility to schizophrenia by several genome-wide association studies, follow-up association studies and meta-analyses. This SNP has been shown to affect neuronal connectivities and cognitive abilities. We investigated an association between the ZNF804A genotype of rs1344706 and schizotypal personality traits using the Schizotypal Personality Questionnaire (SPQ) in 176 healthy subjects. We also looked for specific associations among ZNF804A polymorphisms and the three factors of schizotypy-cognitive/perceptual, interpersonal and disorganization-assessed by the SPQ. The total score for the SPQ in carriers of the risk T allele was significantly higher than that in individuals with the G/G genotype (p= 0.042). For the three factors derived from the SPQ, carriers with the risk T allele showed a higher disorganization factor (p= 0.011), but there were no differences in the cognitive/perceptual or interpersonal factors between genotype groups (p> 0.30). These results suggest that the genetic variation in ZNF804A might increase susceptibility not only for schizophrenia but also for schizotypal personality traits in healthy subjects.

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