Impaired IL-15 production associated with susceptibility of murine AIDS to mycobacterial infection

Masayuki Umemura; Kenji Hirose; Worawidh Wajjwalku; Hitoshi Nishimura; Tetsuya Matsuguchi; Yoshitaka Gotoh; Masahide Takahashi; Masahiko Makino; Yasunobu Yoshikai

Impaired IL-15 production associated with susceptibility of murine AIDS to mycobacterial infection

Masayuki Umemura, Kenji Hirose, Worawidh Wajjwalku, Hitoshi Nishimura, Tetsuya Matsuguchi, Yoshitaka Gotoh, Masahide Takahashi, Masahiko Makino, Yasunobu Yoshikai

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

LP-BM5 murine leukemia virus (MuLV) injection causes murine AIDS (MAIDS), a disease characterized by many functional abnormalities of immunocompetent cells. We show that MAIDS mice are susceptible to Mycobacterium bovis Bacille Calmette-Guérin (BCG) infection as assessed by survival rate and bacterial counts. The peritoneal exudate macrophages from MAIDS mice produced a significant level of interleukin (IL)-12 soon after inoculation with BCG, whereas IL-15 and tumor necrosis factor (TNF) production were severely impaired in BCG-infected MAIDS mice. The appearance of natural killer (NK) and CD4⁺ T helper type 1 (Th1) cells specific for mycobacterial antigen were depressed in MAIDS mice after BCG infection. Thus, it appeared that impaired production of IL-15, besides other inflammatory cytokines, in MAIDS mice may be involved in the poor responses of the NK and Th1 cells, resulting in an increased susceptibility to BCG.

Original language	English
Pages (from-to)	138-148
Number of pages	11
Journal	Journal of Leukocyte Biology
Volume	69
Issue number	1
Publication status	Published - 2001
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Impaired IL-15 production associated with susceptibility of murine AIDS to mycobacterial infection",

abstract = "LP-BM5 murine leukemia virus (MuLV) injection causes murine AIDS (MAIDS), a disease characterized by many functional abnormalities of immunocompetent cells. We show that MAIDS mice are susceptible to Mycobacterium bovis Bacille Calmette-Gu{\'e}rin (BCG) infection as assessed by survival rate and bacterial counts. The peritoneal exudate macrophages from MAIDS mice produced a significant level of interleukin (IL)-12 soon after inoculation with BCG, whereas IL-15 and tumor necrosis factor (TNF) production were severely impaired in BCG-infected MAIDS mice. The appearance of natural killer (NK) and CD4+ T helper type 1 (Th1) cells specific for mycobacterial antigen were depressed in MAIDS mice after BCG infection. Thus, it appeared that impaired production of IL-15, besides other inflammatory cytokines, in MAIDS mice may be involved in the poor responses of the NK and Th1 cells, resulting in an increased susceptibility to BCG.",

author = "Masayuki Umemura and Kenji Hirose and Worawidh Wajjwalku and Hitoshi Nishimura and Tetsuya Matsuguchi and Yoshitaka Gotoh and Masahide Takahashi and Masahiko Makino and Yasunobu Yoshikai",

year = "2001",

language = "English",

volume = "69",

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journal = "Journal of Leukocyte Biology",

issn = "0741-5400",

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TY - JOUR

T1 - Impaired IL-15 production associated with susceptibility of murine AIDS to mycobacterial infection

AU - Umemura, Masayuki

AU - Hirose, Kenji

AU - Wajjwalku, Worawidh

AU - Nishimura, Hitoshi

AU - Matsuguchi, Tetsuya

AU - Gotoh, Yoshitaka

AU - Takahashi, Masahide

AU - Makino, Masahiko

AU - Yoshikai, Yasunobu

PY - 2001

Y1 - 2001

N2 - LP-BM5 murine leukemia virus (MuLV) injection causes murine AIDS (MAIDS), a disease characterized by many functional abnormalities of immunocompetent cells. We show that MAIDS mice are susceptible to Mycobacterium bovis Bacille Calmette-Guérin (BCG) infection as assessed by survival rate and bacterial counts. The peritoneal exudate macrophages from MAIDS mice produced a significant level of interleukin (IL)-12 soon after inoculation with BCG, whereas IL-15 and tumor necrosis factor (TNF) production were severely impaired in BCG-infected MAIDS mice. The appearance of natural killer (NK) and CD4+ T helper type 1 (Th1) cells specific for mycobacterial antigen were depressed in MAIDS mice after BCG infection. Thus, it appeared that impaired production of IL-15, besides other inflammatory cytokines, in MAIDS mice may be involved in the poor responses of the NK and Th1 cells, resulting in an increased susceptibility to BCG.

AB - LP-BM5 murine leukemia virus (MuLV) injection causes murine AIDS (MAIDS), a disease characterized by many functional abnormalities of immunocompetent cells. We show that MAIDS mice are susceptible to Mycobacterium bovis Bacille Calmette-Guérin (BCG) infection as assessed by survival rate and bacterial counts. The peritoneal exudate macrophages from MAIDS mice produced a significant level of interleukin (IL)-12 soon after inoculation with BCG, whereas IL-15 and tumor necrosis factor (TNF) production were severely impaired in BCG-infected MAIDS mice. The appearance of natural killer (NK) and CD4+ T helper type 1 (Th1) cells specific for mycobacterial antigen were depressed in MAIDS mice after BCG infection. Thus, it appeared that impaired production of IL-15, besides other inflammatory cytokines, in MAIDS mice may be involved in the poor responses of the NK and Th1 cells, resulting in an increased susceptibility to BCG.

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AN - SCOPUS:0035148811

SN - 0741-5400

VL - 69

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JO - Journal of Leukocyte Biology

JF - Journal of Leukocyte Biology

IS - 1

ER -

Impaired IL-15 production associated with susceptibility of murine AIDS to mycobacterial infection

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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