Impaired wound healing and expansion of a large ulcer after bevacizumab with paclitaxel for skin metastases from breast cancer: report of a case

Yuko Kijima, Heiji Yoshinaka, Munetsugu Hirata, Akihiro Nakajo, Hideo Arima, Yoshiaki Shinden, Tetsuya Ijichi, Yuka Eguchi, Hiroshi Okumura, Yoshikazu Uenosono, Hiroshi Kurahara, Sumiya Ishigami, Shoji Natsugoe

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 48-year-old Japanese woman was found to have local recurrence of breast cancer in the chest wall following neoadjuvant chemotherapy, total mastectomy with axillary lymphadenectomy, postoperative radiation therapy to the chest wall, and adjuvant systemic therapy using trastuzumab. As a third line of treatment after recurrence, bevacizumab with paclitaxel was initiated for several metastatic lesions on the skin of the chest wall, left internal costal lymph nodes, and right axillary lymph nodes. The wound on the chest wall continued to expand in diameter and depth after the third course of bevacizumab with paclitaxel until the rib was exposed. After stopping the bevacizumab, granulation tissue expanded and by 3 months, had covered the bottom of the ulcer. The patient died soon thereafter, despite systemic chemotherapy with eribulin; however, there was no further bleeding from the ulcer on the chest wall or the exposed ribs.

Original languageEnglish
Pages (from-to)498-502
Number of pages5
JournalSurgery Today
Volume45
Issue number4
DOIs
Publication statusPublished - 01-01-2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery

Fingerprint Dive into the research topics of 'Impaired wound healing and expansion of a large ulcer after bevacizumab with paclitaxel for skin metastases from breast cancer: report of a case'. Together they form a unique fingerprint.

  • Cite this

    Kijima, Y., Yoshinaka, H., Hirata, M., Nakajo, A., Arima, H., Shinden, Y., Ijichi, T., Eguchi, Y., Okumura, H., Uenosono, Y., Kurahara, H., Ishigami, S., & Natsugoe, S. (2015). Impaired wound healing and expansion of a large ulcer after bevacizumab with paclitaxel for skin metastases from breast cancer: report of a case. Surgery Today, 45(4), 498-502. https://doi.org/10.1007/s00595-014-0912-6