TY - JOUR
T1 - Impairment of active avoidance response in rats with continuous infusion of quinolinic acid into the lateral ventricle
AU - Yamada, Kiyofumi
AU - Nabeshima, Toshitaka
AU - Kameyama, Tsutomu
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1991/1
Y1 - 1991/1
N2 - Continuous infusion of quinolinic acid (QA) at low doses into the lateral ventricle has been previously shown to cause a reduction of the hippocampal and cortical ChAT activities in rats although GAD activities were unchanged. In the present study, we have studied behavioral changes in rats with continuous infusion of QA in an active avoidance task. Acquisition of active avoidance was significantly impaired in rats with QA infusion compared to control. These results suggest that continuous infusion of QA is a useful technique for the study of chronic neurodegenerative diseases associated with memory impairement.
AB - Continuous infusion of quinolinic acid (QA) at low doses into the lateral ventricle has been previously shown to cause a reduction of the hippocampal and cortical ChAT activities in rats although GAD activities were unchanged. In the present study, we have studied behavioral changes in rats with continuous infusion of QA in an active avoidance task. Acquisition of active avoidance was significantly impaired in rats with QA infusion compared to control. These results suggest that continuous infusion of QA is a useful technique for the study of chronic neurodegenerative diseases associated with memory impairement.
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U2 - 10.1248/bpb1978.14.351
DO - 10.1248/bpb1978.14.351
M3 - Article
C2 - 1838394
AN - SCOPUS:0025788931
SN - 0386-846X
VL - 14
SP - 351
EP - 355
JO - Journal of Pharmacobio-Dynamics
JF - Journal of Pharmacobio-Dynamics
IS - 6
ER -