TY - JOUR
T1 - Impairment of Trk-neurotrophin receptor by the serum of a patient with subacute sensory neuropathy
AU - Mutoh, Tatsuro
AU - Tachi, Masayuki
AU - Yano, Shigeaki
AU - Mihara, Takateru
AU - Yamamoto, Hiroko
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/10
Y1 - 2005/10
N2 - Background: Paraneoplastic peripheral neuropathy is sometimes associated with unidentified neuronal autoantibodies. Objective: To examine the effects of serum from a patient with subacute sensory axonopathy on the function of the Trk high-affinity nerve growth factor receptor. Patient: An 86-year-old man with sensory neuropathy exhibiting an autoantibody to Trk. Methods: Immunoblot analyses of the brain homogenates and immunoprecipitation were performed with human sera. We further examined the effect of sera on nerve growth factor-induced neurite outgrowth and Trk autophosphorylation. Results: The patient showed sensory nerve axonopathy without well-known paraneoplastic autoantibodies. His serum inhibited nerve growth factor-induced neurite outgrowth and Trk autophosphorylation in PCtrk cells. Moreover, the patient's serum, but not control serum, immunoprecipitated Trk and recognized Trk in brain homogenates as well as in Trk immunoprecipitates. Conclusion: These data strongly suggest that an anti-Trk autoantibody might cause subacute sensory neuropathy.
AB - Background: Paraneoplastic peripheral neuropathy is sometimes associated with unidentified neuronal autoantibodies. Objective: To examine the effects of serum from a patient with subacute sensory axonopathy on the function of the Trk high-affinity nerve growth factor receptor. Patient: An 86-year-old man with sensory neuropathy exhibiting an autoantibody to Trk. Methods: Immunoblot analyses of the brain homogenates and immunoprecipitation were performed with human sera. We further examined the effect of sera on nerve growth factor-induced neurite outgrowth and Trk autophosphorylation. Results: The patient showed sensory nerve axonopathy without well-known paraneoplastic autoantibodies. His serum inhibited nerve growth factor-induced neurite outgrowth and Trk autophosphorylation in PCtrk cells. Moreover, the patient's serum, but not control serum, immunoprecipitated Trk and recognized Trk in brain homogenates as well as in Trk immunoprecipitates. Conclusion: These data strongly suggest that an anti-Trk autoantibody might cause subacute sensory neuropathy.
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U2 - 10.1001/archneur.62.10.1612
DO - 10.1001/archneur.62.10.1612
M3 - Article
C2 - 16216947
AN - SCOPUS:26444606931
VL - 62
SP - 1612
EP - 1615
JO - Archives of Neurology
JF - Archives of Neurology
SN - 0003-9942
IS - 10
ER -