Improved resection and outcome of colon-cancer liver metastasis with fluorescence-guided surgery using in situ GFP labeling with a telomerase-dependent adenovirus in an orthotopic mouse model

Shuya Yano; Kiyoto Takehara; Shinji Miwa; Hiroyuki Kishimoto; Yukihiko Hiroshima; Takashi Murakami; Yasuo Urata; Shunsuke Kagawa; Michael Bouvet; Toshiyoshi Fujiwara; Robert M. Hoffman

doi:10.1371/journal.pone.0148760

Improved resection and outcome of colon-cancer liver metastasis with fluorescence-guided surgery using in situ GFP labeling with a telomerase-dependent adenovirus in an orthotopic mouse model

Shuya Yano
, Kiyoto Takehara
, Shinji Miwa
, Hiroyuki Kishimoto
, Yukihiko Hiroshima
, Takashi Murakami
, Yasuo Urata
, Shunsuke Kagawa
, Michael Bouvet
, Toshiyoshi Fujiwara
, Robert M. Hoffman

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Fluorescence-guided surgery (FGS) of cancer is an area of intense development. In the present report, we demonstrate that the telomerase-dependent green fluorescent protein (GFP)-containing adenovirus OBP-401 could label colon-cancer liver metastasis in situ in an orthotopic mouse model enabling successful FGS. OBP-401-GFP-labeled liver metastasis resulted in complete resection with FGS, in contrast, conventional bright-light surgery (BLS) did not result in complete resection of the metastasis. OBP-401-FGS reduced the recurrence rate and prolonged over-all survival compared with BLS. In conclusion, adenovirus OBP-401 is a powerful tool to label liver metastasis in situ with GFP which enables its complete resection, not possible with conventional BLS.

Original language	English
Article number	e0148760
Journal	PloS one
Volume	11
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0148760
Publication status	Published - 02-2016
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General

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10.1371/journal.pone.0148760

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Yano, S., Takehara, K., Miwa, S., Kishimoto, H., Hiroshima, Y., Murakami, T., Urata, Y., Kagawa, S., Bouvet, M., Fujiwara, T., & Hoffman, R. M. (2016). Improved resection and outcome of colon-cancer liver metastasis with fluorescence-guided surgery using in situ GFP labeling with a telomerase-dependent adenovirus in an orthotopic mouse model. PloS one, 11(2), Article e0148760. https://doi.org/10.1371/journal.pone.0148760

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title = "Improved resection and outcome of colon-cancer liver metastasis with fluorescence-guided surgery using in situ GFP labeling with a telomerase-dependent adenovirus in an orthotopic mouse model",

abstract = "Fluorescence-guided surgery (FGS) of cancer is an area of intense development. In the present report, we demonstrate that the telomerase-dependent green fluorescent protein (GFP)-containing adenovirus OBP-401 could label colon-cancer liver metastasis in situ in an orthotopic mouse model enabling successful FGS. OBP-401-GFP-labeled liver metastasis resulted in complete resection with FGS, in contrast, conventional bright-light surgery (BLS) did not result in complete resection of the metastasis. OBP-401-FGS reduced the recurrence rate and prolonged over-all survival compared with BLS. In conclusion, adenovirus OBP-401 is a powerful tool to label liver metastasis in situ with GFP which enables its complete resection, not possible with conventional BLS.",

author = "Shuya Yano and Kiyoto Takehara and Shinji Miwa and Hiroyuki Kishimoto and Yukihiko Hiroshima and Takashi Murakami and Yasuo Urata and Shunsuke Kagawa and Michael Bouvet and Toshiyoshi Fujiwara and Hoffman, \{Robert M.\}",

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Yano, S, Takehara, K, Miwa, S, Kishimoto, H, Hiroshima, Y, Murakami, T, Urata, Y, Kagawa, S, Bouvet, M, Fujiwara, T & Hoffman, RM 2016, 'Improved resection and outcome of colon-cancer liver metastasis with fluorescence-guided surgery using in situ GFP labeling with a telomerase-dependent adenovirus in an orthotopic mouse model', PloS one, vol. 11, no. 2, e0148760. https://doi.org/10.1371/journal.pone.0148760

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AU - Yano, Shuya

AU - Takehara, Kiyoto

AU - Miwa, Shinji

AU - Kishimoto, Hiroyuki

AU - Hiroshima, Yukihiko

AU - Murakami, Takashi

AU - Urata, Yasuo

AU - Kagawa, Shunsuke

AU - Bouvet, Michael

AU - Fujiwara, Toshiyoshi

AU - Hoffman, Robert M.

N1 - Publisher Copyright: © 2016 Yano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2016/2

Y1 - 2016/2

N2 - Fluorescence-guided surgery (FGS) of cancer is an area of intense development. In the present report, we demonstrate that the telomerase-dependent green fluorescent protein (GFP)-containing adenovirus OBP-401 could label colon-cancer liver metastasis in situ in an orthotopic mouse model enabling successful FGS. OBP-401-GFP-labeled liver metastasis resulted in complete resection with FGS, in contrast, conventional bright-light surgery (BLS) did not result in complete resection of the metastasis. OBP-401-FGS reduced the recurrence rate and prolonged over-all survival compared with BLS. In conclusion, adenovirus OBP-401 is a powerful tool to label liver metastasis in situ with GFP which enables its complete resection, not possible with conventional BLS.

AB - Fluorescence-guided surgery (FGS) of cancer is an area of intense development. In the present report, we demonstrate that the telomerase-dependent green fluorescent protein (GFP)-containing adenovirus OBP-401 could label colon-cancer liver metastasis in situ in an orthotopic mouse model enabling successful FGS. OBP-401-GFP-labeled liver metastasis resulted in complete resection with FGS, in contrast, conventional bright-light surgery (BLS) did not result in complete resection of the metastasis. OBP-401-FGS reduced the recurrence rate and prolonged over-all survival compared with BLS. In conclusion, adenovirus OBP-401 is a powerful tool to label liver metastasis in situ with GFP which enables its complete resection, not possible with conventional BLS.

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Improved resection and outcome of colon-cancer liver metastasis with fluorescence-guided surgery using in situ GFP labeling with a telomerase-dependent adenovirus in an orthotopic mouse model

Abstract

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