Improvement in patient outcomes following endovascular treatment of WFNS grade v subarachnoid haemorrhage from 2000 to 2014

Joji Inamasu, Akiyo Sadato, Motoki Oheda, Motoharu Hayakawa, Shunsuke Nakae, Tatsuo Ohmi, Kazuhide Adachi, Ichiro Nakahara, Yuichi Hirose

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Patient outcomes following grade V subarachnoid haemorrhage (SAH) have been dismal, although they may have improved following recent technological advances in endovascular treatment (EVT). A single-centre, retrospective study was conducted to evaluate whether outcomes have improved from 2000 to 2014 for patients with World Federation of Neurosurgical Societies (WFNS) grade V SAH. Coiling has been the preferred first-line treatment for grade V SAH patients in our institution since 2000. Patients who underwent EVT (n = 115) were grouped on the basis of their hospital admission year: 2000-2004 (n = 44), 2005-2009 (n = 37) and 2010-2014 (n = 34). Patient demographics, outcomes and in-hospital mortality rates were compared between the groups. Patient outcomes at discharge were evaluated using the Glasgow Outcome Scale (GOS), with GOS scores of 4-5 defined as favourable outcomes. There were no significant intergroup differences in patient demographics. In addition, there were no significant differences in the frequencies of favourable outcomes (14% in 2000-2004, 16% in 2005-2009 and 26% in 2010-2014). Mortality rates were 52% in 2000-2004, 43% in 2005-2009 and 24% in 2010-2014, with a significantly lower mortality rate in 2010-2014 than in 2000-2004 (p = 0.01). Both perioperative rebleeding and delayed cerebral ischaemia decreased over time; however, multivariate regression analysis showed that the former contributed more to the decrease in mortality. Age was the only variable associated with favourable outcomes. The results of this study indicate that EVT is an appropriate therapeutic option for grade V SAH patients. However, multi-centre, prospective trials are required to provide evidence-based verification of the efficacy of EVT.

Original languageEnglish
Pages (from-to)114-118
Number of pages5
JournalJournal of Clinical Neuroscience
Volume27
DOIs
Publication statusPublished - 01-05-2016

Fingerprint

Subarachnoid Hemorrhage
Glasgow Outcome Scale
Mortality
Therapeutics
Demography
Hospital Mortality
Brain Ischemia
Multivariate Analysis
Retrospective Studies
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Inamasu, Joji ; Sadato, Akiyo ; Oheda, Motoki ; Hayakawa, Motoharu ; Nakae, Shunsuke ; Ohmi, Tatsuo ; Adachi, Kazuhide ; Nakahara, Ichiro ; Hirose, Yuichi. / Improvement in patient outcomes following endovascular treatment of WFNS grade v subarachnoid haemorrhage from 2000 to 2014. In: Journal of Clinical Neuroscience. 2016 ; Vol. 27. pp. 114-118.
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abstract = "Patient outcomes following grade V subarachnoid haemorrhage (SAH) have been dismal, although they may have improved following recent technological advances in endovascular treatment (EVT). A single-centre, retrospective study was conducted to evaluate whether outcomes have improved from 2000 to 2014 for patients with World Federation of Neurosurgical Societies (WFNS) grade V SAH. Coiling has been the preferred first-line treatment for grade V SAH patients in our institution since 2000. Patients who underwent EVT (n = 115) were grouped on the basis of their hospital admission year: 2000-2004 (n = 44), 2005-2009 (n = 37) and 2010-2014 (n = 34). Patient demographics, outcomes and in-hospital mortality rates were compared between the groups. Patient outcomes at discharge were evaluated using the Glasgow Outcome Scale (GOS), with GOS scores of 4-5 defined as favourable outcomes. There were no significant intergroup differences in patient demographics. In addition, there were no significant differences in the frequencies of favourable outcomes (14{\%} in 2000-2004, 16{\%} in 2005-2009 and 26{\%} in 2010-2014). Mortality rates were 52{\%} in 2000-2004, 43{\%} in 2005-2009 and 24{\%} in 2010-2014, with a significantly lower mortality rate in 2010-2014 than in 2000-2004 (p = 0.01). Both perioperative rebleeding and delayed cerebral ischaemia decreased over time; however, multivariate regression analysis showed that the former contributed more to the decrease in mortality. Age was the only variable associated with favourable outcomes. The results of this study indicate that EVT is an appropriate therapeutic option for grade V SAH patients. However, multi-centre, prospective trials are required to provide evidence-based verification of the efficacy of EVT.",
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Improvement in patient outcomes following endovascular treatment of WFNS grade v subarachnoid haemorrhage from 2000 to 2014. / Inamasu, Joji; Sadato, Akiyo; Oheda, Motoki; Hayakawa, Motoharu; Nakae, Shunsuke; Ohmi, Tatsuo; Adachi, Kazuhide; Nakahara, Ichiro; Hirose, Yuichi.

In: Journal of Clinical Neuroscience, Vol. 27, 01.05.2016, p. 114-118.

Research output: Contribution to journalArticle

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AU - Nakae, Shunsuke

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AU - Hirose, Yuichi

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