In vitro responses of Acinetobacter baumannii to two- and three-drug combinations following exposure to colistin and doripenem

Louise M. Oleksiuk, M. Hong Nguyen, Ellen G. Press, Cassaundra L. Updike, Jessica A. O'Hara, Yohei Doi, Cornelius J. Clancy, Ryan K. Shields

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Abstract

We compared in vitro killing of colistin, doripenem, and sulbactam by time-kill methods against Acinetobacter baumannii isolates collected from patients before and after colistin-doripenem treatment (initial and recurrent isolates, respectively). Colistindoripenem bactericidal activity against recurrent isolates was attenuated (mean log10 kill,-5.74 versus-2.88; P=0.01) but was restored by adding sulbactam. Doripenem MICs rather than colistin MICs correlated with the activity of colistin-doripenem. Among colistin-resistant isolates, colistin-doripenem-sulbactam combinations achieved greater killing than colistin-doripenem alone (-5.65 versus-2.43; P=0.04).

Original languageEnglish
Pages (from-to)1195-1199
Number of pages5
JournalAntimicrobial agents and chemotherapy
Volume58
Issue number2
DOIs
Publication statusPublished - 01-02-2014
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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