In vitro responses of Acinetobacter baumannii to two- and three-drug combinations following exposure to colistin and doripenem

Louise M. Oleksiuk; M. Hong Nguyen; Ellen G. Press; Cassaundra L. Updike; Jessica A. O'Hara; Yohei Doi; Cornelius J. Clancy; Ryan K. Shields

doi:10.1128/AAC.01779-13

In vitro responses of Acinetobacter baumannii to two- and three-drug combinations following exposure to colistin and doripenem

Louise M. Oleksiuk, M. Hong Nguyen, Ellen G. Press, Cassaundra L. Updike, Jessica A. O'Hara, Yohei Doi, Cornelius J. Clancy, Ryan K. Shields

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

We compared in vitro killing of colistin, doripenem, and sulbactam by time-kill methods against Acinetobacter baumannii isolates collected from patients before and after colistin-doripenem treatment (initial and recurrent isolates, respectively). Colistindoripenem bactericidal activity against recurrent isolates was attenuated (mean log10 kill,-5.74 versus-2.88; P=0.01) but was restored by adding sulbactam. Doripenem MICs rather than colistin MICs correlated with the activity of colistin-doripenem. Among colistin-resistant isolates, colistin-doripenem-sulbactam combinations achieved greater killing than colistin-doripenem alone (-5.65 versus-2.43; P=0.04).

Original language	English
Pages (from-to)	1195-1199
Number of pages	5
Journal	Antimicrobial agents and chemotherapy
Volume	58
Issue number	2
DOIs	https://doi.org/10.1128/AAC.01779-13
Publication status	Published - 02-2014
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.01779-13

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title = "In vitro responses of Acinetobacter baumannii to two- and three-drug combinations following exposure to colistin and doripenem",

abstract = "We compared in vitro killing of colistin, doripenem, and sulbactam by time-kill methods against Acinetobacter baumannii isolates collected from patients before and after colistin-doripenem treatment (initial and recurrent isolates, respectively). Colistindoripenem bactericidal activity against recurrent isolates was attenuated (mean log10 kill,-5.74 versus-2.88; P=0.01) but was restored by adding sulbactam. Doripenem MICs rather than colistin MICs correlated with the activity of colistin-doripenem. Among colistin-resistant isolates, colistin-doripenem-sulbactam combinations achieved greater killing than colistin-doripenem alone (-5.65 versus-2.43; P=0.04).",

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AU - Nguyen, M. Hong

AU - Press, Ellen G.

AU - Updike, Cassaundra L.

AU - O'Hara, Jessica A.

AU - Doi, Yohei

AU - Clancy, Cornelius J.

AU - Shields, Ryan K.

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AB - We compared in vitro killing of colistin, doripenem, and sulbactam by time-kill methods against Acinetobacter baumannii isolates collected from patients before and after colistin-doripenem treatment (initial and recurrent isolates, respectively). Colistindoripenem bactericidal activity against recurrent isolates was attenuated (mean log10 kill,-5.74 versus-2.88; P=0.01) but was restored by adding sulbactam. Doripenem MICs rather than colistin MICs correlated with the activity of colistin-doripenem. Among colistin-resistant isolates, colistin-doripenem-sulbactam combinations achieved greater killing than colistin-doripenem alone (-5.65 versus-2.43; P=0.04).

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In vitro responses of Acinetobacter baumannii to two- and three-drug combinations following exposure to colistin and doripenem

Abstract

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UN SDGs

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