In vitro responses of Acinetobacter baumannii to two- and three-drug combinations following exposure to colistin and doripenem

Louise M. Oleksiuk; M. Hong Nguyen; Ellen G. Press; Cassaundra L. Updike; Jessica A. O'Hara; Yohei Doi; Cornelius J. Clancy; Ryan K. Shields

doi:10.1128/AAC.01779-13

In vitro responses of Acinetobacter baumannii to two- and three-drug combinations following exposure to colistin and doripenem

Louise M. Oleksiuk
, M. Hong Nguyen
, Ellen G. Press
, Cassaundra L. Updike
, Jessica A. O'Hara
, Yohei Doi
, Cornelius J. Clancy
, Ryan K. Shields

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

We compared in vitro killing of colistin, doripenem, and sulbactam by time-kill methods against Acinetobacter baumannii isolates collected from patients before and after colistin-doripenem treatment (initial and recurrent isolates, respectively). Colistindoripenem bactericidal activity against recurrent isolates was attenuated (mean log10 kill,-5.74 versus-2.88; P=0.01) but was restored by adding sulbactam. Doripenem MICs rather than colistin MICs correlated with the activity of colistin-doripenem. Among colistin-resistant isolates, colistin-doripenem-sulbactam combinations achieved greater killing than colistin-doripenem alone (-5.65 versus-2.43; P=0.04).

Original language	English
Pages (from-to)	1195-1199
Number of pages	5
Journal	Antimicrobial agents and chemotherapy
Volume	58
Issue number	2
DOIs	https://doi.org/10.1128/AAC.01779-13
Publication status	Published - 02-2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.01779-13

Cite this

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title = "In vitro responses of Acinetobacter baumannii to two- and three-drug combinations following exposure to colistin and doripenem",

abstract = "We compared in vitro killing of colistin, doripenem, and sulbactam by time-kill methods against Acinetobacter baumannii isolates collected from patients before and after colistin-doripenem treatment (initial and recurrent isolates, respectively). Colistindoripenem bactericidal activity against recurrent isolates was attenuated (mean log10 kill,-5.74 versus-2.88; P=0.01) but was restored by adding sulbactam. Doripenem MICs rather than colistin MICs correlated with the activity of colistin-doripenem. Among colistin-resistant isolates, colistin-doripenem-sulbactam combinations achieved greater killing than colistin-doripenem alone (-5.65 versus-2.43; P=0.04).",

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AU - Oleksiuk, Louise M.

AU - Nguyen, M. Hong

AU - Press, Ellen G.

AU - Updike, Cassaundra L.

AU - O'Hara, Jessica A.

AU - Doi, Yohei

AU - Clancy, Cornelius J.

AU - Shields, Ryan K.

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AB - We compared in vitro killing of colistin, doripenem, and sulbactam by time-kill methods against Acinetobacter baumannii isolates collected from patients before and after colistin-doripenem treatment (initial and recurrent isolates, respectively). Colistindoripenem bactericidal activity against recurrent isolates was attenuated (mean log10 kill,-5.74 versus-2.88; P=0.01) but was restored by adding sulbactam. Doripenem MICs rather than colistin MICs correlated with the activity of colistin-doripenem. Among colistin-resistant isolates, colistin-doripenem-sulbactam combinations achieved greater killing than colistin-doripenem alone (-5.65 versus-2.43; P=0.04).

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In vitro responses of Acinetobacter baumannii to two- and three-drug combinations following exposure to colistin and doripenem

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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