In vivo effects of Aloe arborescens Miller var. natalensis Berger (Kidachi aloe) on experimental tinea pedis in guinea-pig feet

K. Kawai, H. Beppu, K. Shimpo, T. Chihara, N. Yamamoto, T. Nagatsu, H. Ueda, Y. Yamada

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Trichophytosis was induced in guinea-pigs and the antifungal effects of Aloe arborescens Miller var. natalensis Berger (Kidachi aloe) evaluated in comparison with lanoconazole, a commercially available antifungal agent. Trichophytosis was induced by inoculation of arthrospores of Trichophyton mentagrophytes cephalic strain SM-110 (T. mentagrophytes SM-110) onto the plantar part of guinea-pig feet. Culture studies after application of 30% freeze-dried Kidachi aloe for 10 days showed a 70% growth inhibition compared with the untreated animals. In an in vitro experiment, the fraction of Kidachi aloe with molecular weights less than 10000 and a bioactive compound of barbaloin, a low molecular weight component of Kidachi aloe, showed growth inhibition of Trichophyton at a minimum concentration of 75 mg/mL and 200 μg/mL.

Original languageEnglish
Pages (from-to)178-182
Number of pages5
JournalPhytotherapy Research
Volume12
Issue number3
DOIs
Publication statusPublished - 05-1998

All Science Journal Classification (ASJC) codes

  • Pharmacology

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