Abstract
Trichophytosis was induced in guinea-pigs and the antifungal effects of Aloe arborescens Miller var. natalensis Berger (Kidachi aloe) evaluated in comparison with lanoconazole, a commercially available antifungal agent. Trichophytosis was induced by inoculation of arthrospores of Trichophyton mentagrophytes cephalic strain SM-110 (T. mentagrophytes SM-110) onto the plantar part of guinea-pig feet. Culture studies after application of 30% freeze-dried Kidachi aloe for 10 days showed a 70% growth inhibition compared with the untreated animals. In an in vitro experiment, the fraction of Kidachi aloe with molecular weights less than 10000 and a bioactive compound of barbaloin, a low molecular weight component of Kidachi aloe, showed growth inhibition of Trichophyton at a minimum concentration of 75 mg/mL and 200 μg/mL.
| Original language | English |
|---|---|
| Pages (from-to) | 178-182 |
| Number of pages | 5 |
| Journal | Phytotherapy Research |
| Volume | 12 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 05-1998 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Pharmacology
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