In vivo effects of Aloe arborescens Miller var. natalensis Berger (Kidachi aloe) on experimental tinea pedis in guinea-pig feet

K. Kawai; H. Beppu; K. Shimpo; Takeshi Chihara; N. Yamamoto; T. Nagatsu; H. Ueda; Y. Yamada

doi:10.1002/(SICI)1099-1573(199805)12:3<178::AID-PTR218>3.0.CO;2-F

In vivo effects of Aloe arborescens Miller var. natalensis Berger (Kidachi aloe) on experimental tinea pedis in guinea-pig feet

K. Kawai
, H. Beppu
, K. Shimpo
, Takeshi Chihara
, N. Yamamoto
, T. Nagatsu
, H. Ueda
, Y. Yamada

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Trichophytosis was induced in guinea-pigs and the antifungal effects of Aloe arborescens Miller var. natalensis Berger (Kidachi aloe) evaluated in comparison with lanoconazole, a commercially available antifungal agent. Trichophytosis was induced by inoculation of arthrospores of Trichophyton mentagrophytes cephalic strain SM-110 (T. mentagrophytes SM-110) onto the plantar part of guinea-pig feet. Culture studies after application of 30% freeze-dried Kidachi aloe for 10 days showed a 70% growth inhibition compared with the untreated animals. In an in vitro experiment, the fraction of Kidachi aloe with molecular weights less than 10000 and a bioactive compound of barbaloin, a low molecular weight component of Kidachi aloe, showed growth inhibition of Trichophyton at a minimum concentration of 75 mg/mL and 200 μg/mL.

Original language	English
Pages (from-to)	178-182
Number of pages	5
Journal	Phytotherapy Research
Volume	12
Issue number	3
DOIs	https://doi.org/10.1002/(SICI)1099-1573(199805)12:3<178::AID-PTR218>3.0.CO;2-F
Publication status	Published - 05-1998
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology

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10.1002/(SICI)1099-1573(199805)12:3<178::AID-PTR218>3.0.CO;2-F

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title = "In vivo effects of Aloe arborescens Miller var. natalensis Berger (Kidachi aloe) on experimental tinea pedis in guinea-pig feet",

abstract = "Trichophytosis was induced in guinea-pigs and the antifungal effects of Aloe arborescens Miller var. natalensis Berger (Kidachi aloe) evaluated in comparison with lanoconazole, a commercially available antifungal agent. Trichophytosis was induced by inoculation of arthrospores of Trichophyton mentagrophytes cephalic strain SM-110 (T. mentagrophytes SM-110) onto the plantar part of guinea-pig feet. Culture studies after application of 30\% freeze-dried Kidachi aloe for 10 days showed a 70\% growth inhibition compared with the untreated animals. In an in vitro experiment, the fraction of Kidachi aloe with molecular weights less than 10000 and a bioactive compound of barbaloin, a low molecular weight component of Kidachi aloe, showed growth inhibition of Trichophyton at a minimum concentration of 75 mg/mL and 200 μg/mL.",

author = "K. Kawai and H. Beppu and K. Shimpo and Takeshi Chihara and N. Yamamoto and T. Nagatsu and H. Ueda and Y. Yamada",

year = "1998",

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doi = "10.1002/(SICI)1099-1573(199805)12:3<178::AID-PTR218>3.0.CO;2-F",

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AU - Kawai, K.

AU - Beppu, H.

AU - Shimpo, K.

AU - Chihara, Takeshi

AU - Yamamoto, N.

AU - Nagatsu, T.

AU - Ueda, H.

AU - Yamada, Y.

PY - 1998/5

Y1 - 1998/5

N2 - Trichophytosis was induced in guinea-pigs and the antifungal effects of Aloe arborescens Miller var. natalensis Berger (Kidachi aloe) evaluated in comparison with lanoconazole, a commercially available antifungal agent. Trichophytosis was induced by inoculation of arthrospores of Trichophyton mentagrophytes cephalic strain SM-110 (T. mentagrophytes SM-110) onto the plantar part of guinea-pig feet. Culture studies after application of 30% freeze-dried Kidachi aloe for 10 days showed a 70% growth inhibition compared with the untreated animals. In an in vitro experiment, the fraction of Kidachi aloe with molecular weights less than 10000 and a bioactive compound of barbaloin, a low molecular weight component of Kidachi aloe, showed growth inhibition of Trichophyton at a minimum concentration of 75 mg/mL and 200 μg/mL.

AB - Trichophytosis was induced in guinea-pigs and the antifungal effects of Aloe arborescens Miller var. natalensis Berger (Kidachi aloe) evaluated in comparison with lanoconazole, a commercially available antifungal agent. Trichophytosis was induced by inoculation of arthrospores of Trichophyton mentagrophytes cephalic strain SM-110 (T. mentagrophytes SM-110) onto the plantar part of guinea-pig feet. Culture studies after application of 30% freeze-dried Kidachi aloe for 10 days showed a 70% growth inhibition compared with the untreated animals. In an in vitro experiment, the fraction of Kidachi aloe with molecular weights less than 10000 and a bioactive compound of barbaloin, a low molecular weight component of Kidachi aloe, showed growth inhibition of Trichophyton at a minimum concentration of 75 mg/mL and 200 μg/mL.

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In vivo effects of Aloe arborescens Miller var. natalensis Berger (Kidachi aloe) on experimental tinea pedis in guinea-pig feet

Abstract

All Science Journal Classification (ASJC) codes

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