In vivo effects of calcium entry blockers on human parathyroid adenoma cells with special reference to calcium sensing ability and the hormone secretion

Y. Horikawa; H. Nakajima; K. Iizuka; A. Imagawa; K. Tomita; E. Shiba; S. Takai; J. Miyagawa; M. Kuwajima; M. Namba; T. Hanafusa; Y. Matsuzawa

In vivo effects of calcium entry blockers on human parathyroid adenoma cells with special reference to calcium sensing ability and the hormone secretion

Y. Horikawa, H. Nakajima, K. Iizuka, A. Imagawa, K. Tomita, E. Shiba, S. Takai, J. Miyagawa, M. Kuwajima, M. Namba, T. Hanafusa, Y. Matsuzawa

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We evaluated the effects of calcium-entry blockers on parathyroid hormone (PTH) secretion by human parathyroid adenoma cells in vitro. Nifedipine and barnidipine inhibited PTH secretion, while diltiazem had no significant effect. Cytosolic calcium concentrations were measured by use of the calcium-sensitive fluorescent dye fluo-3 with confocal laser scanning microscopy. Nifedipine increased the cytosolic concentration of calcium, whereas diltiazem decreased it. Results suggest that, in parathyroid adenoma cells, regulation of PTH secretion with respect to intracellular calcium concentration would be maintained despite differing response of intracellular calcium concentration following exposure to calcium-entry blockers.

Original language	English
Pages (from-to)	87-96
Number of pages	10
Journal	Research Communications in Molecular Pathology and Pharmacology
Volume	106
Issue number	1-2
Publication status	Published - 1999
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Medicine
Pharmacology

Cite this

Horikawa, Y., Nakajima, H., Iizuka, K., Imagawa, A., Tomita, K., Shiba, E., Takai, S., Miyagawa, J., Kuwajima, M., Namba, M., Hanafusa, T., & Matsuzawa, Y. (1999). In vivo effects of calcium entry blockers on human parathyroid adenoma cells with special reference to calcium sensing ability and the hormone secretion. Research Communications in Molecular Pathology and Pharmacology, 106(1-2), 87-96.

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title = "In vivo effects of calcium entry blockers on human parathyroid adenoma cells with special reference to calcium sensing ability and the hormone secretion",

abstract = "We evaluated the effects of calcium-entry blockers on parathyroid hormone (PTH) secretion by human parathyroid adenoma cells in vitro. Nifedipine and barnidipine inhibited PTH secretion, while diltiazem had no significant effect. Cytosolic calcium concentrations were measured by use of the calcium-sensitive fluorescent dye fluo-3 with confocal laser scanning microscopy. Nifedipine increased the cytosolic concentration of calcium, whereas diltiazem decreased it. Results suggest that, in parathyroid adenoma cells, regulation of PTH secretion with respect to intracellular calcium concentration would be maintained despite differing response of intracellular calcium concentration following exposure to calcium-entry blockers.",

author = "Y. Horikawa and H. Nakajima and K. Iizuka and A. Imagawa and K. Tomita and E. Shiba and S. Takai and J. Miyagawa and M. Kuwajima and M. Namba and T. Hanafusa and Y. Matsuzawa",

year = "1999",

language = "English",

volume = "106",

pages = "87--96",

journal = "Research Communications in Molecular Pathology and Pharmacology",

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Horikawa, Y, Nakajima, H, Iizuka, K, Imagawa, A, Tomita, K, Shiba, E, Takai, S, Miyagawa, J, Kuwajima, M, Namba, M, Hanafusa, T & Matsuzawa, Y 1999, 'In vivo effects of calcium entry blockers on human parathyroid adenoma cells with special reference to calcium sensing ability and the hormone secretion', Research Communications in Molecular Pathology and Pharmacology, vol. 106, no. 1-2, pp. 87-96.

In vivo effects of calcium entry blockers on human parathyroid adenoma cells with special reference to calcium sensing ability and the hormone secretion. / Horikawa, Y.; Nakajima, H.; Iizuka, K. et al.
In: Research Communications in Molecular Pathology and Pharmacology, Vol. 106, No. 1-2, 1999, p. 87-96.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - In vivo effects of calcium entry blockers on human parathyroid adenoma cells with special reference to calcium sensing ability and the hormone secretion

AU - Horikawa, Y.

AU - Nakajima, H.

AU - Iizuka, K.

AU - Imagawa, A.

AU - Tomita, K.

AU - Shiba, E.

AU - Takai, S.

AU - Miyagawa, J.

AU - Kuwajima, M.

AU - Namba, M.

AU - Hanafusa, T.

AU - Matsuzawa, Y.

PY - 1999

Y1 - 1999

N2 - We evaluated the effects of calcium-entry blockers on parathyroid hormone (PTH) secretion by human parathyroid adenoma cells in vitro. Nifedipine and barnidipine inhibited PTH secretion, while diltiazem had no significant effect. Cytosolic calcium concentrations were measured by use of the calcium-sensitive fluorescent dye fluo-3 with confocal laser scanning microscopy. Nifedipine increased the cytosolic concentration of calcium, whereas diltiazem decreased it. Results suggest that, in parathyroid adenoma cells, regulation of PTH secretion with respect to intracellular calcium concentration would be maintained despite differing response of intracellular calcium concentration following exposure to calcium-entry blockers.

AB - We evaluated the effects of calcium-entry blockers on parathyroid hormone (PTH) secretion by human parathyroid adenoma cells in vitro. Nifedipine and barnidipine inhibited PTH secretion, while diltiazem had no significant effect. Cytosolic calcium concentrations were measured by use of the calcium-sensitive fluorescent dye fluo-3 with confocal laser scanning microscopy. Nifedipine increased the cytosolic concentration of calcium, whereas diltiazem decreased it. Results suggest that, in parathyroid adenoma cells, regulation of PTH secretion with respect to intracellular calcium concentration would be maintained despite differing response of intracellular calcium concentration following exposure to calcium-entry blockers.

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SN - 1078-0297

VL - 106

SP - 87

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JF - Research Communications in Molecular Pathology and Pharmacology

IS - 1-2

ER -

In vivo effects of calcium entry blockers on human parathyroid adenoma cells with special reference to calcium sensing ability and the hormone secretion

Abstract

All Science Journal Classification (ASJC) codes

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