In vivo live imaging of bone cells

Hiroki Mizuno, Junichi Kikuta, Masaru Ishii

Research output: Contribution to journalReview articlepeer-review

Abstract

There are as many as 200 cell types in the body, and highly sophisticated and varied life phenomena are carried out by cell migration to appropriate places at appropriate times following the appropriate interactions. Recent advances in optical imaging technology using multi-photon excitation microscopy have enabled visualization inside intact bone tissues in living animals without thin sectioning. Using such advanced techniques, the dynamic behaviors of living bone cells on intact bone tissue structures can be elucidated. Here, we focus on recent findings using intravital multi-photon imaging of dynamic biological systems, e.g., bone homeostasis. This novel approach has proven beneficial for understanding the mechanisms underlying the spatiotemporal nature of bone remodeling systems and for evaluating the specific modes of actions of novel drugs currently in development, which will contribute to a new chapter in bone and mineral research.

Original languageEnglish
Pages (from-to)417-422
Number of pages6
JournalHistochemistry and Cell Biology
Volume149
Issue number4
DOIs
Publication statusPublished - 01-04-2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Histology
  • Molecular Biology
  • Medical Laboratory Technology
  • Cell Biology

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