In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse

Misa Suzuki-Anekoji; Atsushi Suzuki; Sz Wei Wu; Kiyohiko Angata; Keith K. Murai; Kazuhiro Sugihara; Tomoya O. Akama; Kay Hooi Khoo; Jun Nakayama; Michiko N. Fukuda; Minoru Fukuda

doi:10.1074/jbc.M112.433474

In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse

Misa Suzuki-Anekoji, Atsushi Suzuki, Sz Wei Wu, Kiyohiko Angata, Keith K. Murai, Kazuhiro Sugihara, Tomoya O. Akama, Kay Hooi Khoo, Jun Nakayama, Michiko N. Fukuda, Minoru Fukuda

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Background: Chst10 transfers sulfate to glucuronic acid to form the HNK-1 antigen carried by glycoproteins and glycolipids in neurons and NK cells. Results: Chst10 transfers sulfate to glucuronidated steroid hormones, and Chst10-deficient mice exhibited subfertility. Conclusion: Subfertility in Chst10 null females is caused by a loss of steroid hormone dysregulation. Significance: This study identified a new regulatory mechanism mediated by sulfation of glucuronidated steroid.

Original language	English
Pages (from-to)	5007-5016
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M112.433474
Publication status	Published - 15-02-2013
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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title = "In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse",

abstract = "Background: Chst10 transfers sulfate to glucuronic acid to form the HNK-1 antigen carried by glycoproteins and glycolipids in neurons and NK cells. Results: Chst10 transfers sulfate to glucuronidated steroid hormones, and Chst10-deficient mice exhibited subfertility. Conclusion: Subfertility in Chst10 null females is caused by a loss of steroid hormone dysregulation. Significance: This study identified a new regulatory mechanism mediated by sulfation of glucuronidated steroid.",

author = "Misa Suzuki-Anekoji and Atsushi Suzuki and Wu, {Sz Wei} and Kiyohiko Angata and Murai, {Keith K.} and Kazuhiro Sugihara and Akama, {Tomoya O.} and Khoo, {Kay Hooi} and Jun Nakayama and Fukuda, {Michiko N.} and Minoru Fukuda",

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doi = "10.1074/jbc.M112.433474",

language = "English",

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T1 - In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse

AU - Suzuki-Anekoji, Misa

AU - Suzuki, Atsushi

AU - Wu, Sz Wei

AU - Angata, Kiyohiko

AU - Murai, Keith K.

AU - Sugihara, Kazuhiro

AU - Akama, Tomoya O.

AU - Khoo, Kay Hooi

AU - Nakayama, Jun

AU - Fukuda, Michiko N.

AU - Fukuda, Minoru

PY - 2013/2/15

Y1 - 2013/2/15

N2 - Background: Chst10 transfers sulfate to glucuronic acid to form the HNK-1 antigen carried by glycoproteins and glycolipids in neurons and NK cells. Results: Chst10 transfers sulfate to glucuronidated steroid hormones, and Chst10-deficient mice exhibited subfertility. Conclusion: Subfertility in Chst10 null females is caused by a loss of steroid hormone dysregulation. Significance: This study identified a new regulatory mechanism mediated by sulfation of glucuronidated steroid.

AB - Background: Chst10 transfers sulfate to glucuronic acid to form the HNK-1 antigen carried by glycoproteins and glycolipids in neurons and NK cells. Results: Chst10 transfers sulfate to glucuronidated steroid hormones, and Chst10-deficient mice exhibited subfertility. Conclusion: Subfertility in Chst10 null females is caused by a loss of steroid hormone dysregulation. Significance: This study identified a new regulatory mechanism mediated by sulfation of glucuronidated steroid.

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In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse

Abstract

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