Inactivation of the p53 Gene Is not Required for Tumorigenesis of Medullary Thyroid Carcinoma or Pheochromocytoma

Ikuo Yana; Tsutomu Nakamura; Eisei Shin; Katsu Karakawa; Hiroki Kurahashi; Yoshihiro Kurita; Tetsuro Kobayashi; Takesada Mori; Isamu Nishisho; Shin‐ichiro ‐i Takai

doi:10.1111/j.1349-7006.1992.tb02730.x

Inactivation of the p53 Gene Is not Required for Tumorigenesis of Medullary Thyroid Carcinoma or Pheochromocytoma

Ikuo Yana
, Tsutomu Nakamura
, Eisei Shin
, Katsu Karakawa
, Hiroki Kurahashi
, Yoshihiro Kurita
, Tetsuro Kobayashi
, Takesada Mori
, Isamu Nishisho
, Shin‐ichiro ‐i Takai

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

A polymerase chain reaction (PCR)‐mediated RNase protection analysis was performed to detect subtle genetic alterations of p53 in medullary thyroid carcinoma (MTC) and pheochromocytoma. None of the 30 pheochromocytomas showed abnormal RNase protection patterns. Only one of 32 MTCs showed an abnormal pattern, and subsequent DNA sequencing of the PCR product revealed that it had a G to C transversion in codon 49 that resulted in a change from aspartic acid to histidine. However, this was a sporadic MTC with no specific clinicopathological characteristics. On the basis of a previous report that genes on chromosome 17p were not deleted in MTCs and were relatively infrequently deleted in pheochromocytomas, our results suggest that the p53 gene is not involved in tumorigenesis of MTC or pheochromocytoma.

Original language	English
Pages (from-to)	1113-1116
Number of pages	4
Journal	Japanese Journal of Cancer Research
Volume	83
Issue number	11
DOIs	https://doi.org/10.1111/j.1349-7006.1992.tb02730.x
Publication status	Published - 11-1992
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

Access to Document

10.1111/j.1349-7006.1992.tb02730.x

Cite this

@article{b0ff95574490489ea4b1de9273f71ccc,

title = "Inactivation of the p53 Gene Is not Required for Tumorigenesis of Medullary Thyroid Carcinoma or Pheochromocytoma",

abstract = "A polymerase chain reaction (PCR)‐mediated RNase protection analysis was performed to detect subtle genetic alterations of p53 in medullary thyroid carcinoma (MTC) and pheochromocytoma. None of the 30 pheochromocytomas showed abnormal RNase protection patterns. Only one of 32 MTCs showed an abnormal pattern, and subsequent DNA sequencing of the PCR product revealed that it had a G to C transversion in codon 49 that resulted in a change from aspartic acid to histidine. However, this was a sporadic MTC with no specific clinicopathological characteristics. On the basis of a previous report that genes on chromosome 17p were not deleted in MTCs and were relatively infrequently deleted in pheochromocytomas, our results suggest that the p53 gene is not involved in tumorigenesis of MTC or pheochromocytoma.",

author = "Ikuo Yana and Tsutomu Nakamura and Eisei Shin and Katsu Karakawa and Hiroki Kurahashi and Yoshihiro Kurita and Tetsuro Kobayashi and Takesada Mori and Isamu Nishisho and Takai, \{Shin‐ichiro ‐i\}",

year = "1992",

month = nov,

doi = "10.1111/j.1349-7006.1992.tb02730.x",

language = "English",

volume = "83",

pages = "1113--1116",

journal = "Japanese Journal of Cancer Research",

issn = "0910-5050",

publisher = "Japanese Cancer Association",

number = "11",

}

TY - JOUR

T1 - Inactivation of the p53 Gene Is not Required for Tumorigenesis of Medullary Thyroid Carcinoma or Pheochromocytoma

AU - Yana, Ikuo

AU - Nakamura, Tsutomu

AU - Shin, Eisei

AU - Karakawa, Katsu

AU - Kurahashi, Hiroki

AU - Kurita, Yoshihiro

AU - Kobayashi, Tetsuro

AU - Mori, Takesada

AU - Nishisho, Isamu

AU - Takai, Shin‐ichiro ‐i

PY - 1992/11

Y1 - 1992/11

N2 - A polymerase chain reaction (PCR)‐mediated RNase protection analysis was performed to detect subtle genetic alterations of p53 in medullary thyroid carcinoma (MTC) and pheochromocytoma. None of the 30 pheochromocytomas showed abnormal RNase protection patterns. Only one of 32 MTCs showed an abnormal pattern, and subsequent DNA sequencing of the PCR product revealed that it had a G to C transversion in codon 49 that resulted in a change from aspartic acid to histidine. However, this was a sporadic MTC with no specific clinicopathological characteristics. On the basis of a previous report that genes on chromosome 17p were not deleted in MTCs and were relatively infrequently deleted in pheochromocytomas, our results suggest that the p53 gene is not involved in tumorigenesis of MTC or pheochromocytoma.

AB - A polymerase chain reaction (PCR)‐mediated RNase protection analysis was performed to detect subtle genetic alterations of p53 in medullary thyroid carcinoma (MTC) and pheochromocytoma. None of the 30 pheochromocytomas showed abnormal RNase protection patterns. Only one of 32 MTCs showed an abnormal pattern, and subsequent DNA sequencing of the PCR product revealed that it had a G to C transversion in codon 49 that resulted in a change from aspartic acid to histidine. However, this was a sporadic MTC with no specific clinicopathological characteristics. On the basis of a previous report that genes on chromosome 17p were not deleted in MTCs and were relatively infrequently deleted in pheochromocytomas, our results suggest that the p53 gene is not involved in tumorigenesis of MTC or pheochromocytoma.

UR - https://www.scopus.com/pages/publications/0027066835

UR - https://www.scopus.com/pages/publications/0027066835#tab=citedBy

U2 - 10.1111/j.1349-7006.1992.tb02730.x

DO - 10.1111/j.1349-7006.1992.tb02730.x

M3 - Article

C2 - 1483923

AN - SCOPUS:0027066835

SN - 0910-5050

VL - 83

SP - 1113

EP - 1116

JO - Japanese Journal of Cancer Research

JF - Japanese Journal of Cancer Research

IS - 11

ER -

Inactivation of the p53 Gene Is not Required for Tumorigenesis of Medullary Thyroid Carcinoma or Pheochromocytoma

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this