Incidence of chronic obstructive pulmonary disease, and the relationship between age and smoking in a Japanese population

Shigeko Kojima, Hiroki Sakakibara, Shinichi Motani, Kunihiko Hirose, Fumio Mizuno, Masahiro Ochiai, Shuji Hashimoto

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Abstract

Background: Accurately evaluating a risk of chronic obstructive pulmonary disease (COPD) requires a large-scale longitudinal study using a standard criterion for diagnosing COPD. There have been only a few such follow-up studies in Europe and no reports in Asia. We estimated the incidence rate and incidence rate ratio (IRR) of age and smoking for COPD in a Japanese population using the diagnosis criterion of the Global Initiative for Chronic Obstructive Lung Disease guidelines. Methods: Subjects were 17,106 participants aged 25-74 years during health check-ups including spirometry from April 1997 through March 2005 in Japan. Total follow-up of participants were 47,652 person-years in males and 25,224 person-years in females. The IRR of age and smoking was estimated using Cox proportional hazard models with both variables. Results: We identified 466 incidence cases of COPD. The incidence rate per 100 person-years was 0.81 (95% confidence interval [CI], 0.73-0.89) in males and 0.31 (0.24-0.38) in females, and significantly increased with age in both sexes. The incidence rate for current smokers was significantly higher than that for male non-smokers but not significantly for females. Among males, the IRR for current smokers with Brinkman Index < 400, 400-799, and 800+ was 1.2 (0.8-1.9), 2.7 (1.9-3.8), and 4.6 (3.3-6.5), respectively. Conclusion: These results indicated that the COPD risk gradually increased with aging, and that there was a dose-response relationship between smoking and COPD risk.

Original languageEnglish
Pages (from-to)54-60
Number of pages7
JournalJournal of epidemiology
Volume17
Issue number2
DOIs
Publication statusPublished - 10-04-2007

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Chronic Obstructive Pulmonary Disease
Smoking
Incidence
Population
Spirometry
Proportional Hazards Models
Longitudinal Studies
Japan
Guidelines
Confidence Intervals
Health

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Kojima, Shigeko ; Sakakibara, Hiroki ; Motani, Shinichi ; Hirose, Kunihiko ; Mizuno, Fumio ; Ochiai, Masahiro ; Hashimoto, Shuji. / Incidence of chronic obstructive pulmonary disease, and the relationship between age and smoking in a Japanese population. In: Journal of epidemiology. 2007 ; Vol. 17, No. 2. pp. 54-60.
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Incidence of chronic obstructive pulmonary disease, and the relationship between age and smoking in a Japanese population. / Kojima, Shigeko; Sakakibara, Hiroki; Motani, Shinichi; Hirose, Kunihiko; Mizuno, Fumio; Ochiai, Masahiro; Hashimoto, Shuji.

In: Journal of epidemiology, Vol. 17, No. 2, 10.04.2007, p. 54-60.

Research output: Contribution to journalArticle

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AU - Kojima, Shigeko

AU - Sakakibara, Hiroki

AU - Motani, Shinichi

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AU - Mizuno, Fumio

AU - Ochiai, Masahiro

AU - Hashimoto, Shuji

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N2 - Background: Accurately evaluating a risk of chronic obstructive pulmonary disease (COPD) requires a large-scale longitudinal study using a standard criterion for diagnosing COPD. There have been only a few such follow-up studies in Europe and no reports in Asia. We estimated the incidence rate and incidence rate ratio (IRR) of age and smoking for COPD in a Japanese population using the diagnosis criterion of the Global Initiative for Chronic Obstructive Lung Disease guidelines. Methods: Subjects were 17,106 participants aged 25-74 years during health check-ups including spirometry from April 1997 through March 2005 in Japan. Total follow-up of participants were 47,652 person-years in males and 25,224 person-years in females. The IRR of age and smoking was estimated using Cox proportional hazard models with both variables. Results: We identified 466 incidence cases of COPD. The incidence rate per 100 person-years was 0.81 (95% confidence interval [CI], 0.73-0.89) in males and 0.31 (0.24-0.38) in females, and significantly increased with age in both sexes. The incidence rate for current smokers was significantly higher than that for male non-smokers but not significantly for females. Among males, the IRR for current smokers with Brinkman Index < 400, 400-799, and 800+ was 1.2 (0.8-1.9), 2.7 (1.9-3.8), and 4.6 (3.3-6.5), respectively. Conclusion: These results indicated that the COPD risk gradually increased with aging, and that there was a dose-response relationship between smoking and COPD risk.

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