Incidence of Peptic Ulcer in Men is Inversely Correlated with Blood Pressure: Study in an Apparently Healthy Japanese Population

Kose Segawa, Yasumasa Niwa, Tomiyasu Arisawa, Tadashi Kato, Hidemi Goto, Eiji Hamajima, Masaya Shimodaira, Akihiro Miyata, Naoki Ohmiya, Yoshihisa Tsukamoto

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To study the role of autonomic nervous innervation in the etiology of peptic ulcer, we investigated the blood pressure in patients with peptic ulcer. Methods: In 100,085 Japanese adults who were undergoing health screening examinations, including barium meal study, there were endoscopic evaluation‐confirmed diagnoses of gastric ulcer in 769 cases and of duodenal ulcer in 344 cases. The blood pressure in those patients was compared with that in 57,208 normal Japanese controls with no gastrointestinal abnormalities, as confirmed by barium meal study. Results: The blood pressure of younger and middle‐aged men with gastric and duodenal ulcer were lower than those of normal control men. In women, except for the diastolic pressure of those in their 50s, the blood pressure in patients with peptic ulcer and normal controls did not differ significantly. The incidence of duodenal ulcer or of gastric ulcer in men was inversely related to the systolic and diastolic pressure. No definite relationship in this respect was seen in women. Conclusions: An inverse relationship was observed between the occurrence of peptic ulcer and the blood pressure level in Japanese men, but not in women. The relationship may be mediated by an inhibitory effect of the sympathetic nervous system on ulcer formation in hypertensive subjects. The reason for the sex difference in this respect is unknown.

Original languageEnglish
Pages (from-to)399-402
Number of pages4
JournalThe American Journal of Gastroenterology
Volume90
Issue number3
DOIs
Publication statusPublished - 03-1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Incidence of Peptic Ulcer in Men is Inversely Correlated with Blood Pressure: Study in an Apparently Healthy Japanese Population'. Together they form a unique fingerprint.

  • Cite this