Incidence of Peptic Ulcer in Men is Inversely Correlated with Blood Pressure

Study in an Apparently Healthy Japanese Population

Kose Segawa, Yasumasa Niwa, Tomiyasu Arisawa, Tadashi Kato, Hidemi Goto, Eiji Hamajima, Masaya Shimodaira, Akihiro Miyata, Naoki Omiya, Yoshihisa Tsukamoto

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To study the role of autonomic nervous innervation in the etiology of peptic ulcer, we investigated the blood pressure in patients with peptic ulcer. Methods: In 100,085 Japanese adults who were undergoing health screening examinations, including barium meal study, there were endoscopic evaluation‐confirmed diagnoses of gastric ulcer in 769 cases and of duodenal ulcer in 344 cases. The blood pressure in those patients was compared with that in 57,208 normal Japanese controls with no gastrointestinal abnormalities, as confirmed by barium meal study. Results: The blood pressure of younger and middle‐aged men with gastric and duodenal ulcer were lower than those of normal control men. In women, except for the diastolic pressure of those in their 50s, the blood pressure in patients with peptic ulcer and normal controls did not differ significantly. The incidence of duodenal ulcer or of gastric ulcer in men was inversely related to the systolic and diastolic pressure. No definite relationship in this respect was seen in women. Conclusions: An inverse relationship was observed between the occurrence of peptic ulcer and the blood pressure level in Japanese men, but not in women. The relationship may be mediated by an inhibitory effect of the sympathetic nervous system on ulcer formation in hypertensive subjects. The reason for the sex difference in this respect is unknown.

Original languageEnglish
Pages (from-to)399-402
Number of pages4
JournalThe American Journal of Gastroenterology
Volume90
Issue number3
DOIs
Publication statusPublished - 01-01-1995

Fingerprint

Peptic Ulcer
Blood Pressure
Incidence
Population
Stomach Ulcer
Duodenal Ulcer
Barium
Meals
Sympathetic Nervous System
Sex Characteristics
Ulcer
Health

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Segawa, Kose ; Niwa, Yasumasa ; Arisawa, Tomiyasu ; Kato, Tadashi ; Goto, Hidemi ; Hamajima, Eiji ; Shimodaira, Masaya ; Miyata, Akihiro ; Omiya, Naoki ; Tsukamoto, Yoshihisa. / Incidence of Peptic Ulcer in Men is Inversely Correlated with Blood Pressure : Study in an Apparently Healthy Japanese Population. In: The American Journal of Gastroenterology. 1995 ; Vol. 90, No. 3. pp. 399-402.
@article{38f06c8876004369abcb04a4e2fbcaee,
title = "Incidence of Peptic Ulcer in Men is Inversely Correlated with Blood Pressure: Study in an Apparently Healthy Japanese Population",
abstract = "Objective: To study the role of autonomic nervous innervation in the etiology of peptic ulcer, we investigated the blood pressure in patients with peptic ulcer. Methods: In 100,085 Japanese adults who were undergoing health screening examinations, including barium meal study, there were endoscopic evaluation‐confirmed diagnoses of gastric ulcer in 769 cases and of duodenal ulcer in 344 cases. The blood pressure in those patients was compared with that in 57,208 normal Japanese controls with no gastrointestinal abnormalities, as confirmed by barium meal study. Results: The blood pressure of younger and middle‐aged men with gastric and duodenal ulcer were lower than those of normal control men. In women, except for the diastolic pressure of those in their 50s, the blood pressure in patients with peptic ulcer and normal controls did not differ significantly. The incidence of duodenal ulcer or of gastric ulcer in men was inversely related to the systolic and diastolic pressure. No definite relationship in this respect was seen in women. Conclusions: An inverse relationship was observed between the occurrence of peptic ulcer and the blood pressure level in Japanese men, but not in women. The relationship may be mediated by an inhibitory effect of the sympathetic nervous system on ulcer formation in hypertensive subjects. The reason for the sex difference in this respect is unknown.",
author = "Kose Segawa and Yasumasa Niwa and Tomiyasu Arisawa and Tadashi Kato and Hidemi Goto and Eiji Hamajima and Masaya Shimodaira and Akihiro Miyata and Naoki Omiya and Yoshihisa Tsukamoto",
year = "1995",
month = "1",
day = "1",
doi = "10.1111/j.1572-0241.1995.tb08234.x",
language = "English",
volume = "90",
pages = "399--402",
journal = "American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "Nature Publishing Group",
number = "3",

}

Incidence of Peptic Ulcer in Men is Inversely Correlated with Blood Pressure : Study in an Apparently Healthy Japanese Population. / Segawa, Kose; Niwa, Yasumasa; Arisawa, Tomiyasu; Kato, Tadashi; Goto, Hidemi; Hamajima, Eiji; Shimodaira, Masaya; Miyata, Akihiro; Omiya, Naoki; Tsukamoto, Yoshihisa.

In: The American Journal of Gastroenterology, Vol. 90, No. 3, 01.01.1995, p. 399-402.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Incidence of Peptic Ulcer in Men is Inversely Correlated with Blood Pressure

T2 - Study in an Apparently Healthy Japanese Population

AU - Segawa, Kose

AU - Niwa, Yasumasa

AU - Arisawa, Tomiyasu

AU - Kato, Tadashi

AU - Goto, Hidemi

AU - Hamajima, Eiji

AU - Shimodaira, Masaya

AU - Miyata, Akihiro

AU - Omiya, Naoki

AU - Tsukamoto, Yoshihisa

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Objective: To study the role of autonomic nervous innervation in the etiology of peptic ulcer, we investigated the blood pressure in patients with peptic ulcer. Methods: In 100,085 Japanese adults who were undergoing health screening examinations, including barium meal study, there were endoscopic evaluation‐confirmed diagnoses of gastric ulcer in 769 cases and of duodenal ulcer in 344 cases. The blood pressure in those patients was compared with that in 57,208 normal Japanese controls with no gastrointestinal abnormalities, as confirmed by barium meal study. Results: The blood pressure of younger and middle‐aged men with gastric and duodenal ulcer were lower than those of normal control men. In women, except for the diastolic pressure of those in their 50s, the blood pressure in patients with peptic ulcer and normal controls did not differ significantly. The incidence of duodenal ulcer or of gastric ulcer in men was inversely related to the systolic and diastolic pressure. No definite relationship in this respect was seen in women. Conclusions: An inverse relationship was observed between the occurrence of peptic ulcer and the blood pressure level in Japanese men, but not in women. The relationship may be mediated by an inhibitory effect of the sympathetic nervous system on ulcer formation in hypertensive subjects. The reason for the sex difference in this respect is unknown.

AB - Objective: To study the role of autonomic nervous innervation in the etiology of peptic ulcer, we investigated the blood pressure in patients with peptic ulcer. Methods: In 100,085 Japanese adults who were undergoing health screening examinations, including barium meal study, there were endoscopic evaluation‐confirmed diagnoses of gastric ulcer in 769 cases and of duodenal ulcer in 344 cases. The blood pressure in those patients was compared with that in 57,208 normal Japanese controls with no gastrointestinal abnormalities, as confirmed by barium meal study. Results: The blood pressure of younger and middle‐aged men with gastric and duodenal ulcer were lower than those of normal control men. In women, except for the diastolic pressure of those in their 50s, the blood pressure in patients with peptic ulcer and normal controls did not differ significantly. The incidence of duodenal ulcer or of gastric ulcer in men was inversely related to the systolic and diastolic pressure. No definite relationship in this respect was seen in women. Conclusions: An inverse relationship was observed between the occurrence of peptic ulcer and the blood pressure level in Japanese men, but not in women. The relationship may be mediated by an inhibitory effect of the sympathetic nervous system on ulcer formation in hypertensive subjects. The reason for the sex difference in this respect is unknown.

UR - http://www.scopus.com/inward/record.url?scp=0028963488&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028963488&partnerID=8YFLogxK

U2 - 10.1111/j.1572-0241.1995.tb08234.x

DO - 10.1111/j.1572-0241.1995.tb08234.x

M3 - Article

VL - 90

SP - 399

EP - 402

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

IS - 3

ER -