Increased activity and intranuclear expression of phospholipase D2 in human renal cancer

Yutong Zhao, Hidetoshi Ehara, Yukihiro Akao, Masayo Shamoto, Yoshihito Nakagawa, Yoshiko Banno, Takashi Deguchi, Nobuko Ohishi, Kunio Yagi, Yoshinori Nozawa

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

We examined the PLD activities of human renal cancers and found that the PLD2 activity was greatly elevated in almost all cases examined as compared with the adjacent normal region. Western blot analysis showed the increased levels of PLD2 protein, but the PLD1 was not discernible. The oleate-dependent PLD activity was very low but appeared to increase in most cases. Interestingly, the immunohistochemical observations indicated the high expression of PLD2 in the nuclei of clear carcinoma cells. This is the first demonstration which suggests the possible involvement of PLD2 in tumorigenesis of renal cancer. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)140-143
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume278
Issue number1
DOIs
Publication statusPublished - 11-11-2000

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Kidney Neoplasms
Oleic Acid
Human Activities
Carcinogenesis
Demonstrations
Western Blotting
Cells
Carcinoma
Proteins
phospholipase D2
1-dodecylpyridoxal

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Zhao, Yutong ; Ehara, Hidetoshi ; Akao, Yukihiro ; Shamoto, Masayo ; Nakagawa, Yoshihito ; Banno, Yoshiko ; Deguchi, Takashi ; Ohishi, Nobuko ; Yagi, Kunio ; Nozawa, Yoshinori. / Increased activity and intranuclear expression of phospholipase D2 in human renal cancer. In: Biochemical and Biophysical Research Communications. 2000 ; Vol. 278, No. 1. pp. 140-143.
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Zhao, Y, Ehara, H, Akao, Y, Shamoto, M, Nakagawa, Y, Banno, Y, Deguchi, T, Ohishi, N, Yagi, K & Nozawa, Y 2000, 'Increased activity and intranuclear expression of phospholipase D2 in human renal cancer', Biochemical and Biophysical Research Communications, vol. 278, no. 1, pp. 140-143. https://doi.org/10.1006/bbrc.2000.3719

Increased activity and intranuclear expression of phospholipase D2 in human renal cancer. / Zhao, Yutong; Ehara, Hidetoshi; Akao, Yukihiro; Shamoto, Masayo; Nakagawa, Yoshihito; Banno, Yoshiko; Deguchi, Takashi; Ohishi, Nobuko; Yagi, Kunio; Nozawa, Yoshinori.

In: Biochemical and Biophysical Research Communications, Vol. 278, No. 1, 11.11.2000, p. 140-143.

Research output: Contribution to journalArticle

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AU - Zhao, Yutong

AU - Ehara, Hidetoshi

AU - Akao, Yukihiro

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AU - Nakagawa, Yoshihito

AU - Banno, Yoshiko

AU - Deguchi, Takashi

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AU - Nozawa, Yoshinori

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