Increased cerebral infarction by cyclic flow reductions: Studies in the guinea pig MCA thrombosis model

Ken Ichi Kawano, Yasuhiko Ikeda, Kazunao Kondo, Kazuo Umemura

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


We have developed a photochemical model of thrombotic middle cerebral artery (MCA) occlusion in the guinea pig for investigating factors contributing to the development of cerebral infarction. In this model, cyclic flow reductions (CFRs) after recanalization of the MCA are a common observation and might contribute to the development of cerebral infarction. Therefore, we sought to measure the time course of recanalization of the guinea pig MCA after the artery had been occluded by a thrombus. Thrombotic occlusion of the MCA was induced by photochemical reaction between intravenously administered rose bengal and transluminal green light for 10, 15, 20, or 30 min. After the thrombotic occlusion of MCA and subsequent spontaneous thrombolysis, blood flow in the MCA gradually recovered to preocclusion level but with frequent CFRs. The recovery of MCA blood flow or duration of CFRs was dependent on the duration of photochemical reaction (extent of endothelial injury); thus, for a 30-min photochemical reaction, CFRs were still observed 24 h after photochemical reaction. In separate experiments, we also investigated the effect of permanent occlusion of the MCA, which was induced by electrocoagulation in the vessel on cerebral infarction. The infarct volume in the permanent occlusion model was smaller than the maximum value in the thrombotic occlusion model (12.5 vs. 17.4%; P < 0.05, n = 6). CFRs may constitute an important factor contributing to the extent of cerebral infarction.

Original languageEnglish
Pages (from-to)R1578-R1583
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number5 44-5
Publication statusPublished - 11-1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)


Dive into the research topics of 'Increased cerebral infarction by cyclic flow reductions: Studies in the guinea pig MCA thrombosis model'. Together they form a unique fingerprint.

Cite this