Increased expression of sucrase and intestinal-type alkaline phosphatase in human gastric carcinomas with progression

Wataru Nakamura, Ken Ichi Inada, Kazuyuki Hirano, Tetsuya Tsukamoto, Hanae Inoue, Kuniyoshi Kito, Akemi Yoshikawa, Shigeo Nakamura, Masae Tatematsu

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The activities of sucrase, total alkaline phosphatase (total ALP) and intestinal-type alkaline phosphatase (I-ALP) were assayed in gastric carcinomas and in their surrounding mucosae from 57 patients with advanced cancers, and the localization of sucrase in 203 carcinomas, including 86 early cancers, was examined immunohistochemically using polyclonal anti-sucrase antibody. All three enzymes were active in the 57 carcinomas as well as in their surrounding mucosae, but the levels were fairly low as compared to those in normal jejunum mucosa. A considerable part of the total ALP activity in tumor specimens was assumed to be due to I-ALP itself. Increased sucrase and I-ALP were found with greater depth of invasion by undifferentiated-type carcinomas. The pattern of immunohistochemical localization of sucrase in the 203 carcinomas also clearly indicated in creased expression with greater depth of invasion even in differentiated-type carcinomas.

Original languageEnglish
Pages (from-to)186-191
Number of pages6
JournalJapanese Journal of Cancer Research
Volume89
Issue number2
DOIs
Publication statusPublished - 02-1998

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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