TY - JOUR
T1 - Increased expression of sucrase and intestinal-type alkaline phosphatase in human gastric carcinomas with progression
AU - Nakamura, Wataru
AU - Inada, Ken Ichi
AU - Hirano, Kazuyuki
AU - Tsukamoto, Tetsuya
AU - Inoue, Hanae
AU - Kito, Kuniyoshi
AU - Yoshikawa, Akemi
AU - Nakamura, Shigeo
AU - Tatematsu, Masae
PY - 1998/2
Y1 - 1998/2
N2 - The activities of sucrase, total alkaline phosphatase (total ALP) and intestinal-type alkaline phosphatase (I-ALP) were assayed in gastric carcinomas and in their surrounding mucosae from 57 patients with advanced cancers, and the localization of sucrase in 203 carcinomas, including 86 early cancers, was examined immunohistochemically using polyclonal anti-sucrase antibody. All three enzymes were active in the 57 carcinomas as well as in their surrounding mucosae, but the levels were fairly low as compared to those in normal jejunum mucosa. A considerable part of the total ALP activity in tumor specimens was assumed to be due to I-ALP itself. Increased sucrase and I-ALP were found with greater depth of invasion by undifferentiated-type carcinomas. The pattern of immunohistochemical localization of sucrase in the 203 carcinomas also clearly indicated in creased expression with greater depth of invasion even in differentiated-type carcinomas.
AB - The activities of sucrase, total alkaline phosphatase (total ALP) and intestinal-type alkaline phosphatase (I-ALP) were assayed in gastric carcinomas and in their surrounding mucosae from 57 patients with advanced cancers, and the localization of sucrase in 203 carcinomas, including 86 early cancers, was examined immunohistochemically using polyclonal anti-sucrase antibody. All three enzymes were active in the 57 carcinomas as well as in their surrounding mucosae, but the levels were fairly low as compared to those in normal jejunum mucosa. A considerable part of the total ALP activity in tumor specimens was assumed to be due to I-ALP itself. Increased sucrase and I-ALP were found with greater depth of invasion by undifferentiated-type carcinomas. The pattern of immunohistochemical localization of sucrase in the 203 carcinomas also clearly indicated in creased expression with greater depth of invasion even in differentiated-type carcinomas.
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U2 - 10.1111/j.1349-7006.1998.tb00547.x
DO - 10.1111/j.1349-7006.1998.tb00547.x
M3 - Article
C2 - 9548446
AN - SCOPUS:0031889218
SN - 0910-5050
VL - 89
SP - 186
EP - 191
JO - Japanese Journal of Cancer Research
JF - Japanese Journal of Cancer Research
IS - 2
ER -
