TY - JOUR
T1 - Increased expression of the adipocytokine omentin in the epicardial adipose tissue of coronary artery disease patients
AU - Harada, Ken
AU - Shibata, Rei
AU - Ouchi, Noriyuki
AU - Tokuda, Yoshiyuki
AU - Funakubo, Hiroshi
AU - Suzuki, Mayu
AU - Kataoka, Takashi
AU - Nagao, Tomoyuki
AU - Okumura, Satoshi
AU - Shinoda, Norihiro
AU - Kato, Bunichi
AU - Sakai, Shinichi
AU - Kato, Masataka
AU - Marui, Nobuyuki
AU - Ishii, Hideki
AU - Amano, Tetsuya
AU - Matsubara, Tatsuaki
AU - Murohara, Toyoaki
N1 - Publisher Copyright:
© 2016 Elsevier Ireland Ltd
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Background and aims Omentin, an adipocytokine secreted by visceral adipose tissue, protects against obesity-linked cardiovascular complications. However, little is known about its role in epicardial adipose tissue (EAT) and coronary artery disease (CAD). We investigated the expression of omentin in EAT from CAD subjects. Methods EAT, subcutaneous adipose tissue (SCAT), and plasma samples were collected from CAD (n = 15; 23.3 ± 3.1 kg/m2) and non-CAD patients (n = 10; 20.8 ± 3.9 kg/m2). Omentin mRNA expression was measured using real-time PCR, while plasma concentrations were measured using an ELISA. EAT volume was determined with 64-slice computed tomography. Results Omentin expression in EAT and EAT volume were higher in CAD patients compared with controls (2.49 ± 2.6 vs. 0.85 ± 0.3, p = 0.002 and 113 ± 58 ml vs. 92.4 ± 30 ml, p = 0.045, respectively). Omentin expression in SCAT was similar between CAD and control patients (1.37 ± 0.84 vs. 1.07 ± 0.55, p = 0.267). Plasma omentin levels were lower in CAD patients compared with controls (343 ± 158 ng/ml vs. 751 ± 579 ng/ml, p = 0.025), and were negatively associated with the expression of omentin in EAT, in patients with CAD (β = −0.78, p = 0.049). On the other hand, there was no association between omentin in EAT and clinical variables in patients with non-CAD. Conclusions Omentin expression increases in the EAT of non-obese CAD patients, despite a decrease in plasma levels, suggesting that omentin may play a role in the pathogenesis of CAD.
AB - Background and aims Omentin, an adipocytokine secreted by visceral adipose tissue, protects against obesity-linked cardiovascular complications. However, little is known about its role in epicardial adipose tissue (EAT) and coronary artery disease (CAD). We investigated the expression of omentin in EAT from CAD subjects. Methods EAT, subcutaneous adipose tissue (SCAT), and plasma samples were collected from CAD (n = 15; 23.3 ± 3.1 kg/m2) and non-CAD patients (n = 10; 20.8 ± 3.9 kg/m2). Omentin mRNA expression was measured using real-time PCR, while plasma concentrations were measured using an ELISA. EAT volume was determined with 64-slice computed tomography. Results Omentin expression in EAT and EAT volume were higher in CAD patients compared with controls (2.49 ± 2.6 vs. 0.85 ± 0.3, p = 0.002 and 113 ± 58 ml vs. 92.4 ± 30 ml, p = 0.045, respectively). Omentin expression in SCAT was similar between CAD and control patients (1.37 ± 0.84 vs. 1.07 ± 0.55, p = 0.267). Plasma omentin levels were lower in CAD patients compared with controls (343 ± 158 ng/ml vs. 751 ± 579 ng/ml, p = 0.025), and were negatively associated with the expression of omentin in EAT, in patients with CAD (β = −0.78, p = 0.049). On the other hand, there was no association between omentin in EAT and clinical variables in patients with non-CAD. Conclusions Omentin expression increases in the EAT of non-obese CAD patients, despite a decrease in plasma levels, suggesting that omentin may play a role in the pathogenesis of CAD.
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U2 - 10.1016/j.atherosclerosis.2016.07.003
DO - 10.1016/j.atherosclerosis.2016.07.003
M3 - Article
C2 - 27450783
AN - SCOPUS:84978522755
SN - 0021-9150
VL - 251
SP - 299
EP - 304
JO - Atherosclerosis
JF - Atherosclerosis
ER -
