Increased fearfulness of Fyn tyrosine kinase deficient mice

Tsuyoshi Miyakawa, Takeshi Yagi, Satoshi Watanabe, Hiroaki Niki

Research output: Contribution to journalArticlepeer-review

78 Citations (Scopus)


Fyn-deficient mice were produced by inserting the β-galactosidase gene (lacZ) into the fyn gene locus. The homozygously Fyn kinase-deficient (fynz/fynz) mice exhibited stronger light aversion in the light-dark choice test and higher fear-response scores in the novelty preference and passive avoidance tests than did the heterozygously Fyn-deficient (+/fynz) mice. These results indicate that fynz/fynz mice are hyperresponsive to fear-inducing stimuli.

Original languageEnglish
Pages (from-to)179-182
Number of pages4
JournalMolecular Brain Research
Issue number1
Publication statusPublished - 11-1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience


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