Increased fearfulness of Fyn tyrosine kinase deficient mice

Tsuyoshi Miyakawa, Takeshi Yagi, Satoshi Watanabe, Hiroaki Niki

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Fyn-deficient mice were produced by inserting the β-galactosidase gene (lacZ) into the fyn gene locus. The homozygously Fyn kinase-deficient (fyn z /fyn z ) mice exhibited stronger light aversion in the light-dark choice test and higher fear-response scores in the novelty preference and passive avoidance tests than did the heterozygously Fyn-deficient (+/fyn z ) mice. These results indicate that fyn z /fyn z mice are hyperresponsive to fear-inducing stimuli.

Original languageEnglish
Pages (from-to)179-182
Number of pages4
JournalMolecular Brain Research
Volume27
Issue number1
DOIs
Publication statusPublished - 01-01-1994
Externally publishedYes

Fingerprint

Proto-Oncogene Proteins c-fyn
Fear
Galactosidases
Light
Lac Operon
Phosphotransferases
Genes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Miyakawa, Tsuyoshi ; Yagi, Takeshi ; Watanabe, Satoshi ; Niki, Hiroaki. / Increased fearfulness of Fyn tyrosine kinase deficient mice. In: Molecular Brain Research. 1994 ; Vol. 27, No. 1. pp. 179-182.
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Increased fearfulness of Fyn tyrosine kinase deficient mice. / Miyakawa, Tsuyoshi; Yagi, Takeshi; Watanabe, Satoshi; Niki, Hiroaki.

In: Molecular Brain Research, Vol. 27, No. 1, 01.01.1994, p. 179-182.

Research output: Contribution to journalArticle

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