Increased fearfulness of Fyn tyrosine kinase deficient mice

Tsuyoshi Miyakawa; Takeshi Yagi; Satoshi Watanabe; Hiroaki Niki

doi:10.1016/0169-328X(94)90201-1

Increased fearfulness of Fyn tyrosine kinase deficient mice

Tsuyoshi Miyakawa, Takeshi Yagi, Satoshi Watanabe, Hiroaki Niki

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

Fyn-deficient mice were produced by inserting the β-galactosidase gene (lacZ) into the fyn gene locus. The homozygously Fyn kinase-deficient (fyn^z/fyn^z) mice exhibited stronger light aversion in the light-dark choice test and higher fear-response scores in the novelty preference and passive avoidance tests than did the heterozygously Fyn-deficient (+/fyn^z) mice. These results indicate that fyn^z/fyn^z mice are hyperresponsive to fear-inducing stimuli.

Original language	English
Pages (from-to)	179-182
Number of pages	4
Journal	Molecular Brain Research
Volume	27
Issue number	1
DOIs	https://doi.org/10.1016/0169-328X(94)90201-1
Publication status	Published - 11-1994
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/0169-328X(94)90201-1

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title = "Increased fearfulness of Fyn tyrosine kinase deficient mice",

abstract = "Fyn-deficient mice were produced by inserting the β-galactosidase gene (lacZ) into the fyn gene locus. The homozygously Fyn kinase-deficient (fynz/fynz) mice exhibited stronger light aversion in the light-dark choice test and higher fear-response scores in the novelty preference and passive avoidance tests than did the heterozygously Fyn-deficient (+/fynz) mice. These results indicate that fynz/fynz mice are hyperresponsive to fear-inducing stimuli.",

author = "Tsuyoshi Miyakawa and Takeshi Yagi and Satoshi Watanabe and Hiroaki Niki",

note = "Funding Information: supported in part by Grant-in-Aid for Cooperative Research 05301011 to H. Niki for 1993-1994 from the Japanese Ministry of Education, Science and Culture.",

year = "1994",

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doi = "10.1016/0169-328X(94)90201-1",

language = "English",

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pages = "179--182",

journal = "Molecular Brain Research",

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T1 - Increased fearfulness of Fyn tyrosine kinase deficient mice

AU - Miyakawa, Tsuyoshi

AU - Yagi, Takeshi

AU - Watanabe, Satoshi

AU - Niki, Hiroaki

N1 - Funding Information: supported in part by Grant-in-Aid for Cooperative Research 05301011 to H. Niki for 1993-1994 from the Japanese Ministry of Education, Science and Culture.

PY - 1994/11

Y1 - 1994/11

N2 - Fyn-deficient mice were produced by inserting the β-galactosidase gene (lacZ) into the fyn gene locus. The homozygously Fyn kinase-deficient (fynz/fynz) mice exhibited stronger light aversion in the light-dark choice test and higher fear-response scores in the novelty preference and passive avoidance tests than did the heterozygously Fyn-deficient (+/fynz) mice. These results indicate that fynz/fynz mice are hyperresponsive to fear-inducing stimuli.

AB - Fyn-deficient mice were produced by inserting the β-galactosidase gene (lacZ) into the fyn gene locus. The homozygously Fyn kinase-deficient (fynz/fynz) mice exhibited stronger light aversion in the light-dark choice test and higher fear-response scores in the novelty preference and passive avoidance tests than did the heterozygously Fyn-deficient (+/fynz) mice. These results indicate that fynz/fynz mice are hyperresponsive to fear-inducing stimuli.

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Increased fearfulness of Fyn tyrosine kinase deficient mice

Abstract

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