Increased heterogeneity of tyrosine hydroxylase in humans

Hiroshi Ichinose, Tamae Oe, Keisuke Fujita, Mitsuo Yoshida, Shintaroh Ueda, Toshiharu Nagatsu

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Humans produce four different forms of tyrosine hydroxylase (TH) mRNA via alternative splicing of the gene. Here we demonstrate that New- and Old-World monkeys and the gorilla produce only two of the TH isoforms. Comparison among the genomic DNA sequences of various primates revealed that mutations that had accumulated in the genomic DNA created a new exon, resulting in the appearance of two new TH isoforms in man. These findings offer new insight into the sequence of events leading to the evolution of the higher primates into separate species. They also represent what may be the first evidence of a genetic difference between man and primates with respect to a specific brain function.

Original languageEnglish
Pages (from-to)158-165
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume195
Issue number1
DOIs
Publication statusPublished - 31-08-1993

Fingerprint

Tyrosine 3-Monooxygenase
Primates
Protein Isoforms
Platyrrhini
Cercopithecidae
Gorilla gorilla
DNA sequences
Alternative Splicing
Exons
Brain
Genes
Messenger RNA
Mutation
DNA

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Ichinose, Hiroshi ; Oe, Tamae ; Fujita, Keisuke ; Yoshida, Mitsuo ; Ueda, Shintaroh ; Nagatsu, Toshiharu. / Increased heterogeneity of tyrosine hydroxylase in humans. In: Biochemical and Biophysical Research Communications. 1993 ; Vol. 195, No. 1. pp. 158-165.
@article{0635991bd10941da8bb8ceca32425fd6,
title = "Increased heterogeneity of tyrosine hydroxylase in humans",
abstract = "Humans produce four different forms of tyrosine hydroxylase (TH) mRNA via alternative splicing of the gene. Here we demonstrate that New- and Old-World monkeys and the gorilla produce only two of the TH isoforms. Comparison among the genomic DNA sequences of various primates revealed that mutations that had accumulated in the genomic DNA created a new exon, resulting in the appearance of two new TH isoforms in man. These findings offer new insight into the sequence of events leading to the evolution of the higher primates into separate species. They also represent what may be the first evidence of a genetic difference between man and primates with respect to a specific brain function.",
author = "Hiroshi Ichinose and Tamae Oe and Keisuke Fujita and Mitsuo Yoshida and Shintaroh Ueda and Toshiharu Nagatsu",
year = "1993",
month = "8",
day = "31",
doi = "10.1006/bbrc.1993.2024",
language = "English",
volume = "195",
pages = "158--165",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "1",

}

Increased heterogeneity of tyrosine hydroxylase in humans. / Ichinose, Hiroshi; Oe, Tamae; Fujita, Keisuke; Yoshida, Mitsuo; Ueda, Shintaroh; Nagatsu, Toshiharu.

In: Biochemical and Biophysical Research Communications, Vol. 195, No. 1, 31.08.1993, p. 158-165.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Increased heterogeneity of tyrosine hydroxylase in humans

AU - Ichinose, Hiroshi

AU - Oe, Tamae

AU - Fujita, Keisuke

AU - Yoshida, Mitsuo

AU - Ueda, Shintaroh

AU - Nagatsu, Toshiharu

PY - 1993/8/31

Y1 - 1993/8/31

N2 - Humans produce four different forms of tyrosine hydroxylase (TH) mRNA via alternative splicing of the gene. Here we demonstrate that New- and Old-World monkeys and the gorilla produce only two of the TH isoforms. Comparison among the genomic DNA sequences of various primates revealed that mutations that had accumulated in the genomic DNA created a new exon, resulting in the appearance of two new TH isoforms in man. These findings offer new insight into the sequence of events leading to the evolution of the higher primates into separate species. They also represent what may be the first evidence of a genetic difference between man and primates with respect to a specific brain function.

AB - Humans produce four different forms of tyrosine hydroxylase (TH) mRNA via alternative splicing of the gene. Here we demonstrate that New- and Old-World monkeys and the gorilla produce only two of the TH isoforms. Comparison among the genomic DNA sequences of various primates revealed that mutations that had accumulated in the genomic DNA created a new exon, resulting in the appearance of two new TH isoforms in man. These findings offer new insight into the sequence of events leading to the evolution of the higher primates into separate species. They also represent what may be the first evidence of a genetic difference between man and primates with respect to a specific brain function.

UR - http://www.scopus.com/inward/record.url?scp=0027272963&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027272963&partnerID=8YFLogxK

U2 - 10.1006/bbrc.1993.2024

DO - 10.1006/bbrc.1993.2024

M3 - Article

VL - 195

SP - 158

EP - 165

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 1

ER -