Abstract
Levels of human immunodeficiency virus type 1 (HIV-l) DNA and quinolinic acid were examined in areas of the central nervous system (CNS) and lymphoid organs (LN) from 5 AIDS patients with no clinically apparent CNS compromise (group I), 7 with CNS opportunistic diseases (group II), and 8 with HIV encephalopathy (group III). The brains from patients with HIV encephalopathy not only contained higher levels of HIV-I DNA (cerebrum, P <.01; cerebellum, P <.05) as assessed by quantitative polymerase chain reaction but also showed a higher rate of viral pol region mutations suggestive of zidovudine or didanosine resistance than brains from patients in group I or II (P<.01). CNS quinolinic acid concentrations were significantly higher in group II and III patients than in group I (P =.03), even though quinolinic acid levelsin LN were comparable among the 3 groups. These data suggest that CNS inflammatory changes associated with HIV encephalopathy may be triggered by a local productive HIV-1 infection within the CNS.
Original language | English |
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Pages (from-to) | 639-647 |
Number of pages | 9 |
Journal | Journal of Infectious Diseases |
Volume | 172 |
Issue number | 3 |
DOIs | |
Publication status | Published - 01-01-1995 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Infectious Diseases