Abstract
Levels of human immunodeficiency virus type 1 (HIV-l) DNA and quinolinic acid were examined in areas of the central nervous system (CNS) and lymphoid organs (LN) from 5 AIDS patients with no clinically apparent CNS compromise (group I), 7 with CNS opportunistic diseases (group II), and 8 with HIV encephalopathy (group III). The brains from patients with HIV encephalopathy not only contained higher levels of HIV-I DNA (cerebrum, P <.01; cerebellum, P <.05) as assessed by quantitative polymerase chain reaction but also showed a higher rate of viral pol region mutations suggestive of zidovudine or didanosine resistance than brains from patients in group I or II (P<.01). CNS quinolinic acid concentrations were significantly higher in group II and III patients than in group I (P =.03), even though quinolinic acid levelsin LN were comparable among the 3 groups. These data suggest that CNS inflammatory changes associated with HIV encephalopathy may be triggered by a local productive HIV-1 infection within the CNS.
| Original language | English |
|---|---|
| Pages (from-to) | 639-647 |
| Number of pages | 9 |
| Journal | Journal of Infectious Diseases |
| Volume | 172 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 01-01-1995 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Infectious Diseases
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Increased human immunodeficiency virus (hiv) type 1 dnacontent and quinolinic acid concentration in brain tissues from patients with hiv encephalopathy. / Sei, Shizuko; Saito, Kuniaki; Stewart, Sean K.; Crowley, Jeffrey S.; Brouwers, Pim; Kleiner, David E.; Katz, David A.; Pizzo, Philip A.; Heyes, Melvyn P.
In: Journal of Infectious Diseases, Vol. 172, No. 3, 01.01.1995, p. 639-647.Research output: Contribution to journal › Article
TY - JOUR
T1 - Increased human immunodeficiency virus (hiv) type 1 dnacontent and quinolinic acid concentration in brain tissues from patients with hiv encephalopathy
AU - Sei, Shizuko
AU - Saito, Kuniaki
AU - Stewart, Sean K.
AU - Crowley, Jeffrey S.
AU - Brouwers, Pim
AU - Kleiner, David E.
AU - Katz, David A.
AU - Pizzo, Philip A.
AU - Heyes, Melvyn P.
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Levels of human immunodeficiency virus type 1 (HIV-l) DNA and quinolinic acid were examined in areas of the central nervous system (CNS) and lymphoid organs (LN) from 5 AIDS patients with no clinically apparent CNS compromise (group I), 7 with CNS opportunistic diseases (group II), and 8 with HIV encephalopathy (group III). The brains from patients with HIV encephalopathy not only contained higher levels of HIV-I DNA (cerebrum, P <.01; cerebellum, P <.05) as assessed by quantitative polymerase chain reaction but also showed a higher rate of viral pol region mutations suggestive of zidovudine or didanosine resistance than brains from patients in group I or II (P<.01). CNS quinolinic acid concentrations were significantly higher in group II and III patients than in group I (P =.03), even though quinolinic acid levelsin LN were comparable among the 3 groups. These data suggest that CNS inflammatory changes associated with HIV encephalopathy may be triggered by a local productive HIV-1 infection within the CNS.
AB - Levels of human immunodeficiency virus type 1 (HIV-l) DNA and quinolinic acid were examined in areas of the central nervous system (CNS) and lymphoid organs (LN) from 5 AIDS patients with no clinically apparent CNS compromise (group I), 7 with CNS opportunistic diseases (group II), and 8 with HIV encephalopathy (group III). The brains from patients with HIV encephalopathy not only contained higher levels of HIV-I DNA (cerebrum, P <.01; cerebellum, P <.05) as assessed by quantitative polymerase chain reaction but also showed a higher rate of viral pol region mutations suggestive of zidovudine or didanosine resistance than brains from patients in group I or II (P<.01). CNS quinolinic acid concentrations were significantly higher in group II and III patients than in group I (P =.03), even though quinolinic acid levelsin LN were comparable among the 3 groups. These data suggest that CNS inflammatory changes associated with HIV encephalopathy may be triggered by a local productive HIV-1 infection within the CNS.
UR - http://www.scopus.com/inward/record.url?scp=0029154943&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029154943&partnerID=8YFLogxK
U2 - 10.1093/infdis/172.3.638
DO - 10.1093/infdis/172.3.638
M3 - Article
C2 - 7658054
AN - SCOPUS:0029154943
VL - 172
SP - 639
EP - 647
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 3
ER -