Increased level of tumour necrosis factor-alpha (TNF-α) on the skin of Japanese obese males: measured by quantitative skin blotting

K. Ogai, M. Matsumoto, M. Aoki, T. Minematsu, K. Kitamura, M. Kobayashi, H. Sanada, J. Sugama

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Objective: A state of chronic inflammation, characterized by an increased level of tumour necrosis factor-alpha (TNF-α), is often found in the obese population. The negative effects of elevated TNF-α are not limited to systemic metabolism. It also reportedly affects skin integrity. Recently, the relationship between obesity and skin fragility was reported; however, there has been little insight into how the level of TNF-α in the skin in situ is related to the severity of obesity. In this study, we aimed to measure the level of TNF-α on the skin and to find the relationship between obesity and the level of TNF-α detected on the skin. Methods: We used a novel, non-invasive method called quantitative skin blotting. Fifty-nine healthy (but some were classified as being overweight or obese) Japanese males were enrolled as subjects. The levels of TNF-α detected on the abdominal and thigh skin along with the body composition were measured, followed by a correlation analysis. Results: Significant positive correlations were found between the levels of TNF-α detected on the skin and the severity of obesity such as body mass index (BMI), body fat weight and visceral fat rating. Conclusion: We found that high levels of TNF-α were detected on the skin of Japanese obese males, which implied the higher TNF-α in the skin. The elevation of skin TNF-α may be one factor related to skin fragility that is often found in obese individuals.

Original languageEnglish
Pages (from-to)462-469
Number of pages8
JournalInternational Journal of Cosmetic Science
Volume38
Issue number5
DOIs
Publication statusPublished - 01-10-2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Chemistry (miscellaneous)
  • Ageing
  • Pharmaceutical Science
  • Drug Discovery
  • Dermatology
  • Colloid and Surface Chemistry

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