Increased levels of soluble corin in pre-eclampsia and fetal growth restriction

Jun Miyazaki, Haruki Nishizawa, Asuka Kambayashi, Mayuko Ito, Yoshiteru Noda, Sumire Terasawa, Takema Kato, Hironori Miyamura, Kazuya Shiogama, Takao Sekiya, Hiroki Kurahashi, Takuma Fujii

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Atrial natriuretic peptide is biologically activated by the atrial natriuretic peptide-converting enzyme, corin, and has an important role in regulating blood pressure. We detected elevated serum corin levels in women with pre-eclampsia. Interestingly, the serum corin levels were also found to be elevated in pregnancies with a related disorder, unexplained fetal growth restriction (FGR) without hypertension, suggesting that this phenomenon is not simply a response to maternal hypertension. CORIN mRNA levels were not elevated in placentas from pre-eclampsia or unexplained FGR cases. Likewise, similar signal intensities were found for corin in placental syncytiotrophoblast cells by immunostaining. In contrast, corin signals were higher in maternal decidua cells from pre-eclampsia and unexplained FGR cases. These data suggest that corin may be upregulated in maternal decidua in response to an etiologic pathway that is common to pre-eclampsia and FGR.

Original languageEnglish
Pages (from-to)20-25
Number of pages6
JournalPlacenta
Volume48
DOIs
Publication statusPublished - 01-12-2016

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Fetal Development
Pre-Eclampsia
Decidua
Mothers
Atrial Natriuretic Factor
Hypertension
Trophoblasts
Serum
Placenta
Blood Pressure
Pregnancy
Messenger RNA
Enzymes

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynaecology
  • Developmental Biology

Cite this

Miyazaki, Jun ; Nishizawa, Haruki ; Kambayashi, Asuka ; Ito, Mayuko ; Noda, Yoshiteru ; Terasawa, Sumire ; Kato, Takema ; Miyamura, Hironori ; Shiogama, Kazuya ; Sekiya, Takao ; Kurahashi, Hiroki ; Fujii, Takuma. / Increased levels of soluble corin in pre-eclampsia and fetal growth restriction. In: Placenta. 2016 ; Vol. 48. pp. 20-25.
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Increased levels of soluble corin in pre-eclampsia and fetal growth restriction. / Miyazaki, Jun; Nishizawa, Haruki; Kambayashi, Asuka; Ito, Mayuko; Noda, Yoshiteru; Terasawa, Sumire; Kato, Takema; Miyamura, Hironori; Shiogama, Kazuya; Sekiya, Takao; Kurahashi, Hiroki; Fujii, Takuma.

In: Placenta, Vol. 48, 01.12.2016, p. 20-25.

Research output: Contribution to journalArticle

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AU - Nishizawa, Haruki

AU - Kambayashi, Asuka

AU - Ito, Mayuko

AU - Noda, Yoshiteru

AU - Terasawa, Sumire

AU - Kato, Takema

AU - Miyamura, Hironori

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AU - Sekiya, Takao

AU - Kurahashi, Hiroki

AU - Fujii, Takuma

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