Increased levels of the excitotoxin quinolinic acid in spinal cord following contusion injury

Andrew R. Blight; Kuniaki Saito; Melvyn P. Heyes

doi:10.1016/0006-8993(93)91167-Q

Increased levels of the excitotoxin quinolinic acid in spinal cord following contusion injury

Andrew R. Blight, Kuniaki Saito, Melvyn P. Heyes

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Products of inflammatory phagocytes are potential contributors to secondary pathology following spinal cord trauma. In the present study we quantified the levels of the neurotoxin and product of activated macrophages, quinolinic acid (QUIN), in the lower thoracic spinal cord of adult guinea pigs 5 days after brief compression injury. At the injured site (T13), elevations in tissue QUIN levels (> 10-fold) accompanied proportional increases in the activity of indoleamine-2,3 dioxygenase (> 2-fold) and the concentrations of l-kynurenine (> 2.5-fold). In contrast, no significant changes occured in two uninjured regions examined compared to controls, namely cervical spinal cord (C2) and the somatosensory cortex. Further studies of QUIN as a potential contributor to spinal cord injury are warranted.

Original language	English
Pages (from-to)	314-316
Number of pages	3
Journal	Brain Research
Volume	632
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(93)91167-Q
Publication status	Published - 31-12-1993
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(93)91167-Q

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@article{5b2be5eeaf0d4ef99bdcbebe094d3332,

title = "Increased levels of the excitotoxin quinolinic acid in spinal cord following contusion injury",

abstract = "Products of inflammatory phagocytes are potential contributors to secondary pathology following spinal cord trauma. In the present study we quantified the levels of the neurotoxin and product of activated macrophages, quinolinic acid (QUIN), in the lower thoracic spinal cord of adult guinea pigs 5 days after brief compression injury. At the injured site (T13), elevations in tissue QUIN levels (> 10-fold) accompanied proportional increases in the activity of indoleamine-2,3 dioxygenase (> 2-fold) and the concentrations of l-kynurenine (> 2.5-fold). In contrast, no significant changes occured in two uninjured regions examined compared to controls, namely cervical spinal cord (C2) and the somatosensory cortex. Further studies of QUIN as a potential contributor to spinal cord injury are warranted.",

author = "Blight, {Andrew R.} and Kuniaki Saito and Heyes, {Melvyn P.}",

note = "Funding Information: This study was carried out in part at the Center lk~r Paralysis Research of Purdue University and was partly supported by Grant NS-21122 from NIH, NINDS. We appreciate the technical assistance of Mr. J,S. Crowley and L. Cornio.",

year = "1993",

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doi = "10.1016/0006-8993(93)91167-Q",

language = "English",

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pages = "314--316",

journal = "Brain Research",

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T1 - Increased levels of the excitotoxin quinolinic acid in spinal cord following contusion injury

AU - Blight, Andrew R.

AU - Saito, Kuniaki

AU - Heyes, Melvyn P.

N1 - Funding Information: This study was carried out in part at the Center lk~r Paralysis Research of Purdue University and was partly supported by Grant NS-21122 from NIH, NINDS. We appreciate the technical assistance of Mr. J,S. Crowley and L. Cornio.

PY - 1993/12/31

Y1 - 1993/12/31

N2 - Products of inflammatory phagocytes are potential contributors to secondary pathology following spinal cord trauma. In the present study we quantified the levels of the neurotoxin and product of activated macrophages, quinolinic acid (QUIN), in the lower thoracic spinal cord of adult guinea pigs 5 days after brief compression injury. At the injured site (T13), elevations in tissue QUIN levels (> 10-fold) accompanied proportional increases in the activity of indoleamine-2,3 dioxygenase (> 2-fold) and the concentrations of l-kynurenine (> 2.5-fold). In contrast, no significant changes occured in two uninjured regions examined compared to controls, namely cervical spinal cord (C2) and the somatosensory cortex. Further studies of QUIN as a potential contributor to spinal cord injury are warranted.

AB - Products of inflammatory phagocytes are potential contributors to secondary pathology following spinal cord trauma. In the present study we quantified the levels of the neurotoxin and product of activated macrophages, quinolinic acid (QUIN), in the lower thoracic spinal cord of adult guinea pigs 5 days after brief compression injury. At the injured site (T13), elevations in tissue QUIN levels (> 10-fold) accompanied proportional increases in the activity of indoleamine-2,3 dioxygenase (> 2-fold) and the concentrations of l-kynurenine (> 2.5-fold). In contrast, no significant changes occured in two uninjured regions examined compared to controls, namely cervical spinal cord (C2) and the somatosensory cortex. Further studies of QUIN as a potential contributor to spinal cord injury are warranted.

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JO - Brain Research

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IS - 1-2

ER -

Increased levels of the excitotoxin quinolinic acid in spinal cord following contusion injury

Abstract

All Science Journal Classification (ASJC) codes

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