TY - JOUR
T1 - Increased midkine gene expression in childhood B-precursor acute lymphoblastic leukemia
AU - Hidaka, Hirokazu
AU - Yagasaki, Hiroshi
AU - Takahashi, Yoshiyuki
AU - Hama, Asahito
AU - Nishio, Nobuhiro
AU - Tanaka, Makito
AU - Yoshida, Nao
AU - Villalobos, Itzel Bustos
AU - Wang, Yue
AU - Xu, Yin Yan
AU - Horibe, Keizo
AU - Chen, Sen
AU - Kadomatsu, Kenji
AU - Kojima, Seiji
PY - 2007/8
Y1 - 2007/8
N2 - Midkine (MK) is a heparin-binding growth factor that is overexpressed in a number of solid cancers. However, expression in acute leukemia has not been clarified. We examined MK gene expression using real-time PCR in 94 children with acute leukemia. In 30 of the 41 patients with B-precursor ALL, MK gene expression was overexpressed than normal BM. MK gene was also overexpressed in more than half of patients with FAB M1 and M2 types of AML. Quantification of MK gene by real-time PCR offers particular promise as a prognostic marker and a marker for minimal residual disease in children with B-precursor ALL.
AB - Midkine (MK) is a heparin-binding growth factor that is overexpressed in a number of solid cancers. However, expression in acute leukemia has not been clarified. We examined MK gene expression using real-time PCR in 94 children with acute leukemia. In 30 of the 41 patients with B-precursor ALL, MK gene expression was overexpressed than normal BM. MK gene was also overexpressed in more than half of patients with FAB M1 and M2 types of AML. Quantification of MK gene by real-time PCR offers particular promise as a prognostic marker and a marker for minimal residual disease in children with B-precursor ALL.
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U2 - 10.1016/j.leukres.2006.09.005
DO - 10.1016/j.leukres.2006.09.005
M3 - Article
C2 - 17267033
AN - SCOPUS:34249888766
SN - 0145-2126
VL - 31
SP - 1045
EP - 1051
JO - Leukemia Research
JF - Leukemia Research
IS - 8
ER -