Increased midkine gene expression in childhood B-precursor acute lymphoblastic leukemia

Hirokazu Hidaka; Hiroshi Yagasaki; Yoshiyuki Takahashi; Asahito Hama; Nobuhiro Nishio; Makito Tanaka; Nao Yoshida; Itzel Bustos Villalobos; Yue Wang; Yin Yan Xu; Keizo Horibe; Sen Chen; Kenji Kadomatsu; Seiji Kojima

doi:10.1016/j.leukres.2006.12.008

Increased midkine gene expression in childhood B-precursor acute lymphoblastic leukemia

Hirokazu Hidaka
, Hiroshi Yagasaki
, Yoshiyuki Takahashi
, Asahito Hama
, Nobuhiro Nishio
, Makito Tanaka
, Nao Yoshida
, Itzel Bustos Villalobos
, Yue Wang
, Yin Yan Xu
, Keizo Horibe
, Sen Chen
, Kenji Kadomatsu
, Seiji Kojima

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Midkine (MK) is a heparin-binding growth factor that is overexpressed in a number of solid cancers. However, expression in acute leukemia has not been clarified. We examined MK gene expression using real-time PCR in 94 children with acute leukemia. In 30 of the 41 patients with B-precursor ALL, MK gene expression was overexpressed than normal BM. MK gene was also overexpressed in more than half of patients with FAB M1 and M2 types of AML. Quantification of MK gene by real-time PCR offers particular promise as a prognostic marker and a marker for minimal residual disease in children with B-precursor ALL.

Original language	English
Pages (from-to)	1045-1051
Number of pages	7
Journal	Leukemia Research
Volume	31
Issue number	8
DOIs	https://doi.org/10.1016/j.leukres.2006.12.008
Publication status	Published - 08-2007
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Hematology
Oncology
Cancer Research

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10.1016/j.leukres.2006.12.008

Cite this

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title = "Increased midkine gene expression in childhood B-precursor acute lymphoblastic leukemia",

abstract = "Midkine (MK) is a heparin-binding growth factor that is overexpressed in a number of solid cancers. However, expression in acute leukemia has not been clarified. We examined MK gene expression using real-time PCR in 94 children with acute leukemia. In 30 of the 41 patients with B-precursor ALL, MK gene expression was overexpressed than normal BM. MK gene was also overexpressed in more than half of patients with FAB M1 and M2 types of AML. Quantification of MK gene by real-time PCR offers particular promise as a prognostic marker and a marker for minimal residual disease in children with B-precursor ALL.",

keywords = "Acute leukemia, Children, Midkine, Minimal residual disease, Prognostic factor, Real-time PCR, WT1",

author = "Hirokazu Hidaka and Hiroshi Yagasaki and Yoshiyuki Takahashi and Asahito Hama and Nobuhiro Nishio and Makito Tanaka and Nao Yoshida and Villalobos, \{Itzel Bustos\} and Yue Wang and Xu, \{Yin Yan\} and Keizo Horibe and Sen Chen and Kenji Kadomatsu and Seiji Kojima",

year = "2007",

month = aug,

doi = "10.1016/j.leukres.2006.12.008",

language = "English",

volume = "31",

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journal = "Leukemia Research",

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publisher = "Elsevier Ltd",

number = "8",

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TY - JOUR

T1 - Increased midkine gene expression in childhood B-precursor acute lymphoblastic leukemia

AU - Hidaka, Hirokazu

AU - Yagasaki, Hiroshi

AU - Takahashi, Yoshiyuki

AU - Hama, Asahito

AU - Nishio, Nobuhiro

AU - Tanaka, Makito

AU - Yoshida, Nao

AU - Villalobos, Itzel Bustos

AU - Wang, Yue

AU - Xu, Yin Yan

AU - Horibe, Keizo

AU - Chen, Sen

AU - Kadomatsu, Kenji

AU - Kojima, Seiji

PY - 2007/8

Y1 - 2007/8

N2 - Midkine (MK) is a heparin-binding growth factor that is overexpressed in a number of solid cancers. However, expression in acute leukemia has not been clarified. We examined MK gene expression using real-time PCR in 94 children with acute leukemia. In 30 of the 41 patients with B-precursor ALL, MK gene expression was overexpressed than normal BM. MK gene was also overexpressed in more than half of patients with FAB M1 and M2 types of AML. Quantification of MK gene by real-time PCR offers particular promise as a prognostic marker and a marker for minimal residual disease in children with B-precursor ALL.

AB - Midkine (MK) is a heparin-binding growth factor that is overexpressed in a number of solid cancers. However, expression in acute leukemia has not been clarified. We examined MK gene expression using real-time PCR in 94 children with acute leukemia. In 30 of the 41 patients with B-precursor ALL, MK gene expression was overexpressed than normal BM. MK gene was also overexpressed in more than half of patients with FAB M1 and M2 types of AML. Quantification of MK gene by real-time PCR offers particular promise as a prognostic marker and a marker for minimal residual disease in children with B-precursor ALL.

KW - Acute leukemia

KW - Children

KW - Midkine

KW - Minimal residual disease

KW - Prognostic factor

KW - Real-time PCR

KW - WT1

UR - https://www.scopus.com/pages/publications/34249888766

UR - https://www.scopus.com/pages/publications/34249888766#tab=citedBy

U2 - 10.1016/j.leukres.2006.12.008

DO - 10.1016/j.leukres.2006.12.008

M3 - Article

C2 - 17267033

AN - SCOPUS:34249888766

SN - 0145-2126

VL - 31

SP - 1045

EP - 1051

JO - Leukemia Research

JF - Leukemia Research

IS - 8

ER -

Increased midkine gene expression in childhood B-precursor acute lymphoblastic leukemia

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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