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Increased synthesis of Mcl-1 protein underlies initial survival of EGFR-mutant lung cancer to EGFR inhibitors and provides a novel drug target
Kyung A. Song
, Yasuyuki Hosono
, Crystal Turner
, Sheeba Jacob
, Timothy L. Lochmann
, Yoshiko Murakami
, Neha U. Patel
, Jungoh Ham
, Bin Hu
, Krista M. Powell
, Colin M. Coon
, Brad E. Windle
,
Yuko Oya
, Jennifer E. Koblinski
, Hisashi Harada
, Joel D. Leverson
, Andrew J. Souers
, Aaron N. Hata
, Sosipatros Boikos
, Yasushi Yatabe
Hiromichi Ebi, Anthony C. Faber
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Research output
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Contribution to journal
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Article
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peer-review
56
Citations (Scopus)
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Dive into the research topics of 'Increased synthesis of Mcl-1 protein underlies initial survival of EGFR-mutant lung cancer to EGFR inhibitors and provides a novel drug target'. Together they form a unique fingerprint.
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Pharmacology, Toxicology and Pharmaceutical Science
Antiapoptotic
7%
Epidermal Growth Factor Receptor
100%
Lung Cancer
100%
Neoplasm
7%
Phosphotransferase Inhibitor
7%
Protein Mcl 1
100%
Keyphrases
Drug-tolerant Cells
25%
EGFR Inhibitors
100%
High-content Microscopy
25%
Initial Survival
100%
Short-term Pressure
25%
Therapeutic Combinations
25%
Biochemistry, Genetics and Molecular Biology
Cancer Cell
23%
Epidermal Growth Factor Receptor
100%
Kinase
7%
Phosphotransferase
7%
Protein Biosynthesis
7%
RNA Sequencing
7%
RNA Translation
7%
Medicine and Dentistry
EGFR Inhibitors
100%